Balneotherapy + Bupropion
Bupropion brand names: Wellbutrin, Wellbutrin SR, Zyban, Wellbutrin XL, Aplenzin, and others.
We found no known interaction between Balneotherapy and Bupropion in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Balneotherapy and Bupropion
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Bupropion and Balneotherapy in our sources. This does not guarantee that the combination is completely free of risk — research on Balneotherapy alongside specific medications may be limited.
Worth understanding: our licensed dataset holds no drug-interaction record for Balneotherapy at all — not against Bupropion, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
Balneotherapy is a treatment rather than something you take. Tell whoever provides it which medicines you use, and ask your prescriber whether it is appropriate for your health and treatment. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Balneotherapy safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Balneotherapy in Pregnancy & Breastfeeding
When heated balneotherapy is used. Conditions that increase maternal core temperature above 39°C have been associated with increased risk of teratogenicity. Some early research also found an association between maternal heat exposure in the form of a hot tub or sauna during the first trimester and increased risk of neural tube defects. While a more recent analysis of clinical research shows that it is safe for pregnant women to sit in hot baths at 40°C (104°F) or in saunas at 70°C (158°F) for up to 20 minutes, regardless of trimester, clinical practice guidelines by the American College of Obstetricians and Gynecologists still discourage pregnant women from using hot water baths during pregnancy due to possible risks. Until more is known, pregnant women should avoid hot balneotherapy baths and other treatments. There is insufficient reliable information available about the safety of balneotherapy heated to less than 39°C; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Questions About Balneotherapy or Bupropion
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Balneotherapy or Bupropion, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
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Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Bupropion
This page covers Balneotherapy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bupropion page lists 46 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), African Wild Potato (moderate), Artichoke (moderate) and Astaxanthin (moderate).
By severity: 1 major · 33 moderate · 12 minor.
From our pharmacist’s overview on the Bupropion page
“Bupropion (Wellbutrin, Zyban) deserves genuine care around supplements, and the entry to understand first is activated charcoal, the only major-rated interaction on this list. Charcoal and similar bulk products can soak up the drug in the gut and blunt its effect, so space them well apart from your dose.”
Reviewed by 2 · Jul 18, 2026
Where Balneotherapy and Bupropion Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#620 of 1,452 supplements looked up here in the last 7 days
#23 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Balneotherapy reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Balneotherapy and Bupropion records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Balneotherapy
What is Balneotherapy?
- Osteoarthritis joint pain
- Rheumatoid arthritis
- Low back pain
- Fibromyalgia
- Psoriasis and skin conditions
- Relaxation and stress relief
Balneotherapy is a traditional treatment that uses bathing in mineral-rich or thermal water, often combined with mud or other natural elements, mainly for joint and skin problems. Some studies suggest it may ease pain and stiffness in conditions like osteoarthritis, but the quality of evidence is limited and benefits may be short-term. It is generally considered low-risk for healthy adults, but people with heart problems, open wounds, or certain medical conditions should check with a doctor first.
Mineral water, thermal spring water, mud, and other natural bathing media · Mineral or thermal baths, mud packs, spa hydrotherapy, sulfur baths, Dead Sea bathing
An interaction check asks whether these two react with each other — it does not ask whether Balneotherapy is a good idea for someone in your situation. Here is what our Balneotherapy record says about it on its own.
Balneotherapy: dosing
There is no single standardized "dose" for balneotherapy. Treatment programs vary widely in water temperature, mineral content, length of each session, and number of sessions per week. Avoid very hot water and overly long sessions, and stop if you feel dizzy, overheated, or unwell.
From our Balneotherapy monograph — the full record covers uses, side effects and every documented interaction.
About Bupropion
What Is Bupropion Used For?
Brand names: Wellbutrin, Wellbutrin SR, Zyban, Wellbutrin XL, Aplenzin, Forfivo XL
Bupropion is FDA-approved to treat major depressive disorder (MDD) — a form of clinical depression. Extended-release formulations (XL and hydrobromide versions, including Aplenzin) are also approved for the prevention of seasonal affective disorder (SAD), the pattern of depression that tends to arrive in autumn and winter.
Not all formulations share every indication. Aplenzin (bupropion hydrobromide extended-release) and bupropion hydrochloride extended-release tablets (XL) are indicated for both MDD and SAD. Bupropion hydrochloride extended-release tablets (SR) and bupropion hydrochloride immediate-release tablets are indicated for MDD only.
Most-Reported Side Effects for Bupropion
From FAERS, the FDA’s public side-effect reporting system (152,137 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Balneotherapy
Browse every other medication we’ve checked against Balneotherapy — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Balneotherapy against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Ibuprofen ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Balneotherapy list.
Balneotherapy References
The 31 references that drive our Balneotherapy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Sukenik S, Baradin R, Codish S, et al. Balneotherapy at the Dead Sea area for patients with psoriatic arthritis and concomitant fibromyalgia. Isr Med Assoc J 2001;3:147-50.
- Ardic F, Ozgen M, Aybek H, et al. Effects of balneotherapy on serum IL-1, PGE2 and LTB4 levels in fibromyalgia patients. Rheumatol Int 2007;27:441-6. PubMed
- Altan L, Bingol U, Aslan M, Yurtkuran M. The effect of balneotherapy on patients with ankylosing spondylitis. Scand J Rheumatol 2006;35:283-9. PubMed
- Pittler MH, Karagulle MZ, Karagulle M, Ernst E. Spa therapy and balneotherapy for treating low back pain: meta-analysis of randomized trials. Rheumatology (Oxford) 2006;45:880-4. PubMed
- Yurtkuran M, Ay A, Karakoc Y. Improvement of the clinical outcome in Ankylosing spondylitis by balneotherapy. Joint Bone Spine 2005;72:303-8. PubMed
- Tsoureli-Nikita E, Menchini G, Ghersetich I, Hercogova J. Alternative treatment of psoriasis with balneotherapy using Leopoldine spa water. J Eur Acad Dermatol Venereol 2002;16:260-2. PubMed
- Evicik D, Kizilay B, Gokcen E. The effects of balneotherapy on fibromyalgia patients. Rheumatol Int 2002;22:56-9. PubMed
- Buskila D, Abu-Shakra M, Neumann L, et al. Balneotherapy for fibromyalgia at the Dead Sea. Rheumatol Int 2001;20:105-8. PubMed
- Ravanelli N, Casasola W, English T, Edwards KM, Jay O. Heat stress and fetal risk. Environmental limits for exercise and passive heat stress during pregnancy: a systematic review with best evidence synthesis. Br J Sports Med. 2018;0:1-8. PubMed
- Milunsky A, Ulcickas M, Rothman KJ, et al. Maternal heat exposure and neural tube defects. JAMA. 1992;268(7):882-5. DOI
- [No authors listed]. ACOG Committee Opinion No. 650: physical activity and exercise during pregnancy and the postpartum period. Obstet Gynecol 2015;126:e135-42. PubMed
- Bagdatli AO, Donmez A, Eröksüz R, Bahadir G, Turan M, Erdogan N. Does addition of 'mud-pack and hot pool treatment' to patient education make a difference in fibromyalgia patients? A randomized controlled single blind study. Int J Biometeorol. 2015;59(12) PubMed
- Karagülle M, Kardes S, Disçi R, Karagülle MZ. Spa therapy adjunct to pharmacotherapy is beneficial in rheumatoid arthritis: a crossover randomized controlled trial. Int J Biometeorol. 2018;62(2):195-205. PubMed
- Karagülle M, Kardes S, Karagülle MZ. Long-term efficacy of spa therapy in patients with rheumatoid arthritis. Rheumatol Int. 2018;38(3):353-362. PubMed
- Koçyigit BF, Gür A, Altindag Ö, Akyol A, Gürsoy S. Comparison of education and balneotherapy efficacy in patients with fibromyalgia syndrome: A randomized, controlled clinical study. Agri. 2016;28(2):72-8. PubMed
- Kovács C, Bozsik Á, Pecze M, et al. Effects of sulfur bath on hip osteoarthritis: a randomized, controlled, single-blind, follow-up trial: a pilot study. Int J Biometeorol. 2016;60(11):1675-1680. PubMed
- Naumann J, Sadaghiani C. Therapeutic benefit of balneotherapy and hydrotherapy in the management of fibromyalgia syndrome: a qualitative systematic review and meta-analysis of randomized controlled trials. Arthritis Res Ther. 2014;16(4):R141. PubMed
- Verhagen AP, Bierma-Zeinstra SM, Boers M, et al. Balneotherapy (or spa therapy) for rheumatoid arthritis. Cochrane Database Syst Rev. 2015;(4):CD000518. PubMed
- Bai R, Li C, Xiao Y, Sharma M, Zhang F, Zhao Y. Effectiveness of spa therapy for patients with chronic low back pain: An updated systematic review and meta-analysis. Medicine. 2019;98(37):e17092. PubMed
- de Moraes Silva MA, Nakano LC, Cisneros LL, Miranda F Jr. Balneotherapy for chronic venous insufficiency. Cochrane Database Syst Rev. 2019;8(8):CD013085. PubMed
- Chary-Valckenaere I, Loeuille D, Jay N, et al. Spa therapy together with supervised self-mobilisation improves pain, function and quality of life in patients with chronic shoulder pain: a single-blind randomised controlled trial. Int J Biometeorol. 2018;6 PubMed
- Dilekçi E, Özkuk K, Kaki B. The short-term effects of balneotherapy on pain, disability and fatigue in patients with chronic low back pain treated with physical therapy: A randomized controlled trial. Complement Ther Med. 2020;54:102550. PubMed
- Özkuk K, Ateş Z. Balneotherapy in the treatment of chronic shoulder pain: A randomized controlled clinical trial. Altern Ther Health Med. 2020;26(1):18-24.
- Gáti T, Tefner IK, Kovács L, Hodosi K, Bender T. The effects of the calcium-magnesium-bicarbonate content in thermal mineral water on chronic low back pain: a randomized, controlled follow-up study. Int J Biometeorol. 2018;62(5):897-905. PubMed
- Koyuncu E, Ökmen BM, Özkuk K, Taşoğlu Ö, Özgirgin N. The effectiveness of balneotherapy in chronic neck pain. Clin Rheumatol. 2016;35(10):2549-55. PubMed
- Tefner IK, Kovács C, Gaál R, et al. The effect of balneotherapy on chronic shoulder pain. A randomized, controlled, single-blind follow-up trial. A pilot study. Clin Rheumatol. 2015;34(6):1097-108. PubMed
- Farina S, Gisondi P, Zanoni M, et al. Balneotherapy for atopic dermatitis in children at Comano spa in Trentino, Italy. J Dermatolog Treat. 2011;22(6):366-71. PubMed
- Dubois O, Salamon R, Germain C, et al. Balneotherapy versus paroxetine in the treatment of generalized anxiety disorder. Complement Ther Med. 2010;18(1):1-7. PubMed
- Maindet C, Maire A, Vermorel C, et al. Spa Therapy for the Treatment of Fibromyalgia: An Open, Randomized Multicenter Trial. J Pain. 2021 Aug;22(8):940-51. PubMed
- Beylot-Barry M, Mahé E, Rolland C, et al. Evaluation of the benefit of thermal spa therapy in plaque psoriasis: the PSOTHERMES randomized clinical trial. Int J Biometeorol. 2022 Jun;66(6):1247-56. PubMed
- IS, Ibrahim ZM. Beneficial Effects of Paraffin Bath Therapy as Additional Treatment of Chronic Hand Eczema: A Randomized, Single-Blind, Active-Controlled, Parallel-Group Study. J Altern Complement Med. 2020 Dec;26(12):1144-50. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Bupropion Is Linked to Lower Levels of One Nutrient
Natural Medicines records Bupropion as a medicine that can lower these. This is not an interaction with Balneotherapy — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Bupropion nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Having Balneotherapy While Taking Bupropion: Common Questions
Is it safe to have Balneotherapy while taking Bupropion?
Do Balneotherapy and Bupropion have any of the same side effects?
Does Bupropion interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Bupropion and Balneotherapy?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.