Drug & supplement interaction

Beta-cryptoxanthin + Penicillin G Benzathine

Penicillin G Benzathine brand names: Bicillin L-A, Permapen.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Beta-cryptoxanthin and Penicillin G Benzathine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Beta-cryptoxanthin and Penicillin G Benzathine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Penicillin G Benzathine and Beta-cryptoxanthin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Beta-cryptoxanthin at all — not against Penicillin G Benzathine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Beta-cryptoxanthin safety at a glance

Beta-cryptoxanthin overall Use caution Considered safe in normal food amounts, but the safety of high-dose supplements is not well studied.
Pregnancy Likely Safe When used orally and appropriately in amounts found in foods. There is insufficient reliable information available about the safety of supplemental beta-cryptox... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally and appropriately in amounts found in foods. There is insufficient reliable information available about the safety of supplemental beta-cryptox... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Penicillin G Benzathine and Beta-cryptoxanthin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Beta-cryptoxanthin Itself Has Been Linked To

This is not an interaction — nothing below involves Penicillin G Benzathine. It is the side-effect record for Beta-cryptoxanthin on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Beta-cryptoxanthin, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Yellowing of the skin or eyes Worth acting on Additional detail

    “Orally, beta-cryptoxanthin may cause carotenemia. While this yellowing of the skin is benign, carotenemia can be mistaken for jaundice.”

    Beta-cryptoxanthin · Natural Medicines adverse-effect record, reported in neonatal jaundice.

Everything above comes from the Natural Medicines adverse-effect record for Beta-cryptoxanthin — expand a row for the licensed statement it rests on. We haven’t matched Penicillin G Benzathine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Penicillin G Benzathine.

Special populations

Beta-cryptoxanthin in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally and appropriately in amounts found in foods. There is insufficient reliable information available about the safety of supplemental beta-cryptoxanthin; avoid use.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Penicillin G Benzathine

This page covers Beta-cryptoxanthin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Penicillin G Benzathine page lists 56 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), Aristolochia (moderate) and Bacillus Coagulans (moderate).

By severity: 3 major · 42 moderate · 11 minor.

From our pharmacist’s overview on the Penicillin G Benzathine page

“A shot of penicillin G benzathine (Bicillin L-A) usually means strep, syphilis, or monthly prevention of rheumatic fever, and many people reach for probiotics afterward to settle their gut. Probiotics dominate this list of 56 interacting supplements, but the three rated major deserve your attention first, and two of those, Siberian coc…”

Reviewed by 2 · Jul 18, 2026

Open the Penicillin G Benzathine interaction page

How much people look this up

Where Beta-cryptoxanthin and Penicillin G Benzathine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Beta-cryptoxanthin
Steady interest

#740 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Penicillin G Benzathine
Top half

#837 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Beta-cryptoxanthin is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Beta-cryptoxanthin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Beta-cryptoxanthin and Penicillin G Benzathine records this page draws on were last updated October 6, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Beta-cryptoxanthin

What is Beta-cryptoxanthin?

  • Antioxidant support
  • Eye health
  • Bone health
  • Vitamin A source
  • General wellness

Beta-cryptoxanthin is a natural orange-red plant pigment (a carotenoid) found in fruits like oranges, tangerines, and papaya, and it can be turned into vitamin A in the body. Diets rich in beta-cryptoxanthin are linked in some studies to better bone and lung health, but the evidence for supplements is limited. For most people, getting it from colorful fruits and vegetables is the safest and best-studied approach.

Naturally found in fruits and vegetables; also made as a supplement · Capsules, softgels, and multivitamin/carotenoid blends; naturally present in whole foods

An interaction check asks whether these two react with each other — it does not ask whether Beta-cryptoxanthin is a good idea for someone in your situation. Here is what our Beta-cryptoxanthin record says about it on its own.

Beta-cryptoxanthin: dosing

There is no established standard supplement dose for beta-cryptoxanthin. Most research reflects amounts obtained through a normal diet rich in fruits and vegetables rather than from pills.If you choose to take a supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Beta-cryptoxanthin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Beta-cryptoxanthin monograph & all interactions
Medication

About Penicillin G Benzathine Injection

What Is Penicillin G Benzathine Injection Used For?

Brand names: Bicillin L-A, Permapen

Bicillin L-A (penicillin G benzathine) injection is used to treat mild-to-moderate upper respiratory tract infections caused by susceptible streptococci, as well as certain sexually transmitted and tropical infections including syphilis, yaws, bejel, and pinta.

It is also used as long-term preventive therapy to stop recurrence of rheumatic fever, Sydenham's chorea (a movement disorder linked to strep infection), rheumatic heart disease, and acute glomerulonephritis (a type of kidney inflammation).

Most-Reported Side Effects for Penicillin G Benzathine

From FAERS, the FDA’s public side-effect reporting system (1,423 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Recalled product administered 572 reports
Drug hypersensitivity 81 reports
Injection site pain 66 reports
Embolia cutis medicamentosa 49 reports
Acute kidney injury 31 reports
See full Penicillin G Benzathine Injection drug information Penicillin G Benzathine NDC codes and packages
Keep checking

Other Drugs & Beta-cryptoxanthin

Browse every other medication we’ve checked against Beta-cryptoxanthin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Beta-cryptoxanthin References

The 2 sources that drive our Beta-cryptoxanthin monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Beta-cryptoxanthin is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Vitamin A and Carotenoids - Health Professional Fact Sheet — NIH Office of Dietary Supplements Source
  2. Vitamin A — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Beta-cryptoxanthin and Penicillin G Benzathine Together: Common Questions

Is it safe to take Beta-cryptoxanthin with Penicillin G Benzathine?
We do not list a known interaction between Beta-cryptoxanthin and Penicillin G Benzathine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Penicillin G Benzathine interact with any supplements?
Yes. Penicillin G Benzathine has documented interactions with 56 supplements in our database — Beta-cryptoxanthin is not one of them. The Penicillin G Benzathine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Penicillin G Benzathine and Beta-cryptoxanthin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.