Medication interaction hub

What Supplements Interact with Penicillin G Benzathine?

Penicillin G Benzathine brand names: Bicillin L-A, Permapen. Every interaction below applies to the brands too.

56 Interactions 3 Major 42 Moderate 11 Minor
Curated & coded by · Clinical Pharmacist · Updated September 18, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Penicillin G Benzathine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Penicillin G Benzathine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

A shot of penicillin G benzathine (Bicillin L-A) usually means strep, syphilis, or monthly prevention of rheumatic fever, and many people reach for probiotics afterward to settle their gut. Probiotics dominate this list of 56 interacting supplements, but the three rated major deserve your attention first, and two of those, Siberian cocklebur and asarabacca, can add to kidney harm when combined with medicines that already stress the kidneys. I would treat those flags as genuine hazards, not fine print.

The third major entry is activated charcoal, which can lower levels of many medicines even when they are not swallowed, so the injection route offers no protection there. Most of the 42 moderate entries are probiotic strains the antibiotic simply kills off, meaning spacing doses well apart protects the supplement, not you. Six ingredients may lower the seizure threshold, and 11 more rate minor.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 42 Minor 11 No known interaction 1,396

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Penicillin G Benzathine: Top Interactions at a Glance

The most significant Penicillin G Benzathine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 56 interacting ingredients — plus 1,396 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Penicillin G Benzathine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Penicillin G Benzathinei

Siberian cocklebur can adversely affect the kidney.

Read the full interaction Major Likelihood Probable Activated Charcoal + Penicillin G Benzathinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Possible Asarabacca + Penicillin G Benzathinei

Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Read the full interaction
The complete list

Every Supplement Checked Against Penicillin G Benzathine

All 1,452 ingredients in our database, ranked by severity — 56 with a Penicillin G Benzathine interaction on file and 1,396 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Penicillin G Benzathine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Psyllium with Penicillin G Benzathine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Penicillin G Benzathine answer

Can you take Blond Psyllium with Penicillin G Benzathine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Penicillin G Benzathine answer

Can you take Carob with Penicillin G Benzathine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Penicillin G Benzathine answer

Can you take Karaya Gum with Penicillin G Benzathine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Penicillin G Benzathine answer

Can you take Marshmallow with Penicillin G Benzathine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Penicillin G Benzathine answer

Can you take Soy with Penicillin G Benzathine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, antibiotics may decrease the activity of soy isoflavones.

Full Soy + Penicillin G Benzathine answer

Can you take Xanthan Gum with Penicillin G Benzathine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Penicillin G Benzathine answer

Can you take Asian Water Plantain with Penicillin G Benzathine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg o...

Full Asian Water Plantain + Penicillin G Benzathine answer

Can you take Siberian Cocklebur with Penicillin G Benzathine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur can adversely affect the kidney.

Full Siberian Cocklebur + Penicillin G Benzathine answer

Can you take Activated Charcoal with Penicillin G Benzathine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Penicillin G Benzathine answer

Can you take Asarabacca with Penicillin G Benzathine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Full Asarabacca + Penicillin G Benzathine answer

Can you take Bacillus Coagulans with Penicillin G Benzathine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Full Bacillus Coagulans + Penicillin G Benzathine answer

Can you take Bacillus Subtilis with Penicillin G Benzathine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.

Full Bacillus Subtilis + Penicillin G Benzathine answer

Can you take Bifidobacterium Animalis Subsp. Lactis with Penicillin G Benzathine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Animalis Subsp. Lactis + Penicillin G Benzathine answer

Can you take Bifidobacterium Bifidum with Penicillin G Benzathine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium.

Full Bifidobacterium Bifidum + Penicillin G Benzathine answer

Can you take Bifidobacterium Breve with Penicillin G Benzathine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Breve + Penicillin G Benzathine answer

Can you take Bifidobacterium Longum with Penicillin G Benzathine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Longum + Penicillin G Benzathine answer

Can you take Coffee Charcoal with Penicillin G Benzathine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Penicillin G Benzathine answer

Can you take European Mandrake with Penicillin G Benzathine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Penicillin G Benzathine answer

Can you take Fermented Milk with Penicillin G Benzathine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotic drugs might decrease the effectiveness of fermented milk.

Full Fermented Milk + Penicillin G Benzathine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Penicillin G Benzathine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Penicillin G Benzathine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Penicillin G Benzathine sits in 4 interaction categories. Open any one to see what the group means:

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Penicillin G Benzathine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Penicillin G Benzathine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Penicillin G Benzathine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Penicillin G Benzathine through this category.

About Penicillin G Benzathine

Penicillin G benzathine is a long-acting antibiotic injection used to treat certain bacterial infections — including strep throat, syphilis, yaws, bejel, and pinta — and to prevent the return of rheumatic fever.

Generic name: Penicillin G Benzathine  ·  Brand names: Bicillin L-A, Permapen.

See the full Penicillin G Benzathine Injection drug information

Related: does Penicillin G Benzathine deplete any nutrients?

Penicillin G Benzathine has 14 reported nutrient associations in the research literature — see the Penicillin G Benzathine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Penicillin G Benzathine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Penicillin G Benzathine.

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Pharmacist Counseling Corner

Penicillin G Benzathine & Supplements: Common Questions

What supplements interact with Penicillin G Benzathine?
Our database currently documents 56 ingredients with a known Penicillin G Benzathine interaction (3 major, 42 moderate, 11 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 56. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Asarabacca.
Which Penicillin G Benzathine supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Activated Charcoal and Asarabacca. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Penicillin G Benzathine?
Plenty of supplements coexist fine with Penicillin G Benzathine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Bicillin L-A have the same supplement interactions as Penicillin G Benzathine?
Yes — Bicillin L-A, Permapen all contain Penicillin G Benzathine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Penicillin G Benzathine deplete any vitamins or nutrients?
It might — Penicillin G Benzathine has 14 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Penicillin G Benzathine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Penicillin G Benzathine and my other medications?
This page covers Penicillin G Benzathine against supplements and herbal ingredients. Checking Penicillin G Benzathine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Penicillin G Benzathine Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 18, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.