Beth Root + Pemetrexed
Pemetrexed brand names: Alimta, Pemfexy.
We found no known interaction between Beth Root and Pemetrexed in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Beth Root and Pemetrexed
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Pemetrexed and Beth Root in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Beth Root at all — not against Pemetrexed, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Beth Root safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Beth Root in Pregnancy & Breastfeeding
When used orally; avoid using. Beth root might have menstrual or uterine stimulant activity.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Pemetrexed
This page covers Beth Root only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pemetrexed page lists 4 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: African Wild Potato (moderate), Banderol (moderate), Caffeic Acid (moderate) and Quercetin (moderate).
By severity: 4 moderate.
From our pharmacist’s overview on the Pemetrexed page
“Every supplement on file for pemetrexed (Alimta, Pemfexy) works the same way. Each can slow how the kidneys pull the drug out of the blood, which would let it linger and build to higher levels than intended.”
Reviewed by 2 · Jul 18, 2026
Where Beth Root and Pemetrexed Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#798 of 1,452 supplements looked up here in the last 7 days
#950 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Beth Root reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Beth Root and Pemetrexed records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Beth Root
What is Beth Root?
- Heavy menstrual bleeding
- Menstrual cramps
- Childbirth and postpartum bleeding
- Wounds and skin irritation
- Diarrhea
Beth root is a traditional North American plant remedy historically used by Indigenous peoples and folk herbalists, mostly for menstrual and bleeding-related complaints. There is very little modern scientific evidence to show it works for any condition, and its safety has not been well studied, so caution is advised—especially during pregnancy and breastfeeding.
Trillium erectum · Melanthiaceae · Dried root and rhizome · Dried root, tincture, tea, powder, capsules
An interaction check asks whether these two react with each other — it does not ask whether Beth Root is a good idea for someone in your situation. Here is what our Beth Root record says about it on its own.
Beth Root: dosing
There is no established or standardized dose for beth root. It has not been studied enough to know a safe and effective amount, and the strength of products can vary widely.If you choose to use a commercial product, follow the directions on the label and do not exceed them.
From our Beth Root monograph — the full record covers uses, side effects and every documented interaction.
About Pemetrexed Injection
What Is Pemetrexed Injection Used For?
Brand names: Alimta, Pemfexy
Pemetrexed Injection is used for non-squamous non-small cell lung cancer (NSCLC) in several situations: as an initial treatment (combined with pembrolizumab and platinum chemotherapy, or with cisplatin alone), as a maintenance treatment after platinum-based chemotherapy, or as a single agent when the cancer has come back after prior chemotherapy. It is not used for squamous cell non-small cell lung cancer.
Pemetrexed Injection is also used, in combination with cisplatin, for the initial treatment of malignant pleural mesothelioma — a cancer of the lining of the lungs — in patients whose disease cannot be surgically removed or who are not good candidates for surgery.
Most-Reported Side Effects for Pemetrexed
From FAERS, the FDA’s public side-effect reporting system (37,889 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Beth Root
Browse every other medication we’ve checked against Beth Root — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Beth Root against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Hydroxyurea ›
- Methamphetamine ›
- Valacyclovir ›
- Warfarin Sodium ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Amitriptyline ›
- Isotretinoin ›
- Methotrexate ›
- Bupropion ›
- Amlodipine Besylate ›
- Bendamustine ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Methylene Blue ›
- Naproxen ›
- Omeprazole ›
- Levothyroxine, Liothyronine ›
- Letrozole ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Beth Root list.
Beth Root References
The 2 references that drive our Beth Root monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Beth Root and Pemetrexed Together: Common Questions
Is it safe to take Beth Root with Pemetrexed?
Do Beth Root and Pemetrexed have any of the same side effects?
Does Pemetrexed interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.