Black Horehound + Obeticholic Acid
Obeticholic Acid brand name: Ocaliva.
We found no known interaction between Black Horehound and Obeticholic Acid in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Black Horehound and Obeticholic Acid
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Obeticholic Acid and Black Horehound in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Black Horehound safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Obeticholic Acid
Interactions in our licensed database are recorded against drug classes, not just single drug names. Obeticholic Acid is filed under 2 classifications — cytochrome p450 1a2 (cyp1a2) inhibitors, oral drugs. Black Horehound has documented interactions with 1 drug class — the most serious being dopamine agonists (moderate) — and none of Obeticholic Acid’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Black Horehound Does Interact With Other Medications
Black Horehound has 23 moderate known drug interactions in our database — Obeticholic Acid isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Black Horehound
We haven’t checked that one against Black Horehound yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Black Horehound. Pick one to open its full report.
Black Horehound in Pregnancy & Breastfeeding
When used orally; black horehound may affect the menstrual cycle. There is insufficient reliable information available about the safety of black horehound used topically or rectally during pregnancy.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Obeticholic Acid
This page covers Black Horehound only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Obeticholic Acid page lists 27 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Black Tea (moderate), Cocoa (moderate), Coffee Charcoal (moderate) and Cola Nut (moderate).
By severity: 1 major · 14 moderate · 12 minor.
From our pharmacist’s overview on the Obeticholic Acid page
“Obeticholic acid (Ocaliva) protects the liver in primary biliary cholangitis, and it only helps if enough of it stays in your system, which is why I would read this list with real care. Of the 27 supplements and herbs on file, the single major-rated one is activated charcoal, which can bind the drug in your gut and strip it out of circ…”
Reviewed by 2 · Jul 18, 2026
Where Black Horehound and Obeticholic Acid Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#465 of 1,452 supplements looked up here in the last 7 days
#1,639 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Horehound reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Black Horehound and Obeticholic Acid records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Black Horehound
What is Black Horehound?
- Nausea and vomiting
- Anxiety and nervous tension
- Sleep problems
- Mild digestive upset
- Coughs and respiratory complaints
Black horehound is a traditional European herb mainly used for nausea, mild anxiety, and digestive upset, but high-quality human studies are lacking, so its effectiveness is largely unproven. It has a strong, unpleasant smell and taste, and its safety has not been well studied, so it should be avoided in pregnancy and breastfeeding and used cautiously by everyone else.
Ballota nigra · Lamiaceae · Above-ground parts (flowering tops and leaves) · Tea (infusion), liquid extract, tincture, capsules
An interaction check asks whether these two react with each other — it does not ask whether Black Horehound is a good idea for someone in your situation. Here is what our Black Horehound record says about it on its own.
Black Horehound: dosing
There is no well-established, standardized dose for black horehound. Traditional use has involved teas made from the dried herb and liquid extracts or tinctures, but reliable dosing from quality human studies is not available.If you choose to use a product, follow the directions on the label and do not exceed the recommended amount.
From our Black Horehound monograph — the full record covers uses, side effects and every documented interaction.
About Obeticholic Acid
What Is Obeticholic Acid Used For?
Brand name: Ocaliva
-
Obeticholic acid is used alone or in combination with ursodiol (Actigall, Urso) to treat primary biliary cholangitis (PBC; a type of liver disease that destroys bile ducts, which allows bile to stay in the liver and cause damage) in people who cannot take ursodiol or in people who were not treated successfully with ursodiol alone. Obeticholic acid is in a class of medications called farnesoid X receptor agonists. It works by decreasing the production of bile in the liver and increasing the removal of bile from the liver.
Other Drugs & Black Horehound
Browse every other medication we’ve checked against Black Horehound — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
23 interactions
- Apomorphine ›
- Selegiline ›
- Modafinil ›
- Levodopa ›
- Pergolide Mesylate ›
- Ropinirole ›
- Zonisamide ›
- Apomorphine Hydrochloride ›
- Armodafinil ›
- Brexpiprazole ›
- Bromocriptine ›
- Dopamine ›
- Entacapone ›
- Opicapone ›
- Pramipexole ›
- Rasagiline ›
- Rotigotine ›
- Safinamide Mesylate ›
- Tolcapone ›
- Carbidopa, Levodopa ›
- Benserazide, Levodopa ›
- Carbidopa, Levodopa, Entacapone ›
- Levodopa, Carbidopa ›
No interaction 2,806 drugs checked — show the list
We also checked Black Horehound against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,806 medications checked with no known interaction — see the full Black Horehound list.
Black Horehound References
The 2 references that drive our Black Horehound monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Daels-Rakotoarison DA, Seidel V, Gressier B, et al. Neurosedative and antioxidant activities of phenylpropanoids from Ballota nigra. Arzneimittelforschung 2000;50:16-23. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Black Horehound and Obeticholic Acid Together: Common Questions
Is it safe to take Black Horehound with Obeticholic Acid?
How was the Black Horehound and Obeticholic Acid combination checked?
Does Black Horehound interact with any other medications?
Does Obeticholic Acid interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Obeticholic Acid and Black Horehound?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.