Blue-green Algae - Humalog Kwikpen (Insulin Lispro Recombinant) Interaction
Herbal: Blue-green Algae
Also Known As: AFA, Algae, Algues Bleu-Vert du Lac Klamath, BGA, Blue Green Algae, Cyanobacteria, Cyanobactérie, Cyanophycée, Dihe, Espirulina, Hawaiian Spirulina, Klamath Lake Algae, Klamath Blue/Green Algae, SF, SBGA, Spirulina, Spirulina Blue-Green Algae, Spiruline, Tecuitlatl
Drug: Insulin Lispro Recombinant
Brand names:
Humalog Kwikpen
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Insulin Lispro Recombinant is classified as belonging to the following category: Antidiabetes Drugs
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Human research shows that spirulina blue-green algae can have hypoglycemic effects in patients with diabetes, at least some of whom were using antidiabetes drugs. However, blue-green algae does not seem to improve glycated hemoglobin (HbA1c) levels in patients with diabetes. A meta-analysis of animal studies also suggests that spirulina blue-green algae have hypoglycemic effects.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Mani UV, Desai S, Iyer U. Studies on the long-term effect of spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients. J Nutraceut 2000;2(3):25-32.
- Hamedifard Z, Milajerdi A, Reiner Z, Taghizadeh M, Kolahdooz F, Asemi Z. The effects of spirulina on glycemic control and serum lipoproteins in patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized con
- Ghanbari F, Amerizadeh A, Behshood P, Moradi S, Asgary S. Effect of microalgae arthrospira on biomarkers of glycemic control and glucose metabolism: a systematic Review and meta-analysis. Curr Probl Cardiol 2022;47(10):100942.
Blue-green Algae Overview
Blue-green algae, also known as cyanobacteria, are a type of aquatic microorganism. The term 'blue-green algae' can refer to many different types of algae, including Arthrospira genus, which is known as spirulina, and Aphanizomenon flos-aquae, commonly known as 'Klamath', as it is found in Klamath Lake, Oregon.
Blue-green algae contain several different nutrients, including vitamins A, B6, B12, E, and K, iron, manganese, zinc, sodium, potassium, phosphorus, calcium, magnesium, copper, selenium, and chromium.
Blue-green algae have been shown in some samples to be contaminated with several types of toxins, including microcystins and heavy metals, so it is important to only take supplements that are properly tested, processed, and produced.
Blue-green Algae - More Interactions
Blue-green Algae interacts with 315 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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