Drug & supplement interaction

Cade + Ospemifene

Ospemifene brand name: Osphena.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Cade and Ospemifene in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ospemifene states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Cade and Ospemifene

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ospemifene and Cade in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Cade at all — not against Ospemifene, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cade safety at a glance

Cade overall Use caution Generally used topically only and in small amounts; not for internal use and best used under guidance.
Pregnancy Avoid Safety has not been established, so avoid use during pregnancy.
Breastfeeding Avoid Not enough safety information, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ospemifene and Cade? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Cade and Ospemifene May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Bleeding or bruising / Hives Worth acting on reported in 5.8% of FDA reports for Ospemifene Additional detail

    Cade

    “Topical application of cade oil can cause urticaria, localized edema, and purpura. After oral ingestion of a "spoonful" of homemade cade oil, a 32-year old man developed a maculopapular rash with pustular lesions around the nose and mouth.”

    Cade · Natural Medicines adverse-effect record, reported in pregnancy-related edema.

    2 sources cited
    1. 94772. Skalli S, Chebat A, Badrane N, Bencheikh RS. Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012. Food Chem Toxicol 2014;64:81-5. PubMed
    2. 57209. Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49. PubMed

    Ospemifene

    Listed in the ADVERSE REACTIONS section of the FDA label for Ospemifene, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Headache reported in 8.0% of FDA reports for Ospemifene Additional detail

    Cade

    “Topical application of rectified cade oil 1% to 5% is well tolerated (16). Oral use of rectified or crude cade oil and topical use of crude cade oil are associated with serious adverse effects when taken either in single or multiple doses. Adverse effects associated with topical application generally occur in infants and children.”

    Cade · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).

    5 sources cited
    1. 16. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
    2. 94770. Achour S, Abourazzak S, Mokhtari A, et al. Juniper tar (cade oil) poisoning in new born after a cutaneous application. BMJ Case Reports 2011 Oct 28;2011. PubMed
    3. 94772. Skalli S, Chebat A, Badrane N, Bencheikh RS. Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012. Food Chem Toxicol 2014;64:81-5. PubMed
    4. 57209. Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49. PubMed
    5. 94776. Rahmani H, Leonhardt S, Beladdale D, et al. Severe acute lung oedema after rectal enema with cade oil (abstract). European Association of Poisons Centres and Clinical Toxicologists XXIV International Congress, Strasbourg, 2004. Clin Toxicol 2004;42(4):487

    “Oral ingestion and topical application of cade oil have been associated with headache, convulsions, and coma.”

    Cade · Natural Medicines adverse-effect record, reported in cluster headache.

    3 sources cited
    1. 57209. Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49. PubMed
    2. 94770. Achour S, Abourazzak S, Mokhtari A, et al. Juniper tar (cade oil) poisoning in new born after a cutaneous application. BMJ Case Reports 2011 Oct 28;2011. PubMed
    3. 94776. Rahmani H, Leonhardt S, Beladdale D, et al. Severe acute lung oedema after rectal enema with cade oil (abstract). European Association of Poisons Centres and Clinical Toxicologists XXIV International Congress, Strasbourg, 2004. Clin Toxicol 2004;42(4):487

    Ospemifene

    Listed in the ADVERSE REACTIONS section of the FDA label for Ospemifene, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A skin rash Additional detail

    Cade

    Recorded for Cade in the same Natural Medicines adverse-effect record shown under Headache above.

    Ospemifene

    Listed in the ADVERSE REACTIONS section of the FDA label for Ospemifene. Read the label on DailyMed ›

Reported for Cade but not commonly for Ospemifene: an electrolyte imbalance, shortness of breath, cough and a low platelet count.

Effects for Ospemifene come from the ADVERSE REACTIONS section of its FDA label; effects for Cade come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 2,601 voluntary FDA FAERS reports for Ospemifene that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Ospemifene Products Have a Food Rule — Cade Should Not Break It

At least one FDA label for a product containing Ospemifene says to take it with food. If you take Cade on an empty stomach out of habit, keep them separate — and take Ospemifene with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ospemifene products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

One tablet taken orally once daily with food.

From the Dosage and Administration section of the FDA label we read for Ospemifene — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Ospemifene

This page covers Cade only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ospemifene page lists 155 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Tiratricol (major) and Acacia Rigidula (moderate).

By severity: 4 major · 112 moderate · 39 minor.

From our pharmacist’s overview on the Ospemifene page

“Women prescribed ospemifene (Osphena) for painful intercourse after menopause are often the same women reaching for St. John's wort for mood or grapefruit juice at breakfast, and both sit among the four major-rated interactions on this page, so the list deserves genuine care.”

Reviewed by 2 · Jul 18, 2026

Open the Ospemifene interaction page

How much people look this up

Where Cade and Ospemifene Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cade
Steady interest

#917 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ospemifene
Steady interest

#2,527 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cade reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cade and Ospemifene records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cade

What is Cade?

  • Psoriasis and eczema
  • Itchy or scaly scalp (dandruff)
  • Minor skin irritation
  • Antiseptic for the skin
  • Hair and scalp care

Cade oil (juniper tar) is a dark, tar-like oil distilled from the wood of the prickly juniper and is used almost entirely on the skin and scalp for conditions like psoriasis, eczema, and dandruff. Good-quality human research is limited, and there are real safety concerns, so it should only be used on the skin, carefully and in small amounts. Talk with a pharmacist or doctor before using it, and never take it by mouth.

Juniperus oxycedrus · Cupressaceae · Wood and branches, used to make cade oil (juniper tar) · Cade oil (juniper tar), topical creams, ointments, shampoos, and soaps

An interaction check asks whether these two react with each other — it does not ask whether Cade is a good idea for someone in your situation. Here is what our Cade record says about it on its own.

Cade: dosing

There is no established standard dose for cade oil. It is most often found already mixed into shampoos, soaps, creams, or ointments at low concentrations rather than used as a pure oil.The best approach is to follow the directions on the product label and not apply more or more often than recommended.

From our Cade monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cade monograph & all interactions
Medication

About Ospemifene

What Is Ospemifene Used For?

Brand name: Osphena

Osphena (ospemifene) is used to treat two specific symptoms of vulvar and vaginal atrophy — the thinning and drying of vaginal tissues that can happen after menopause. The first is moderate to severe dyspareunia (painful intercourse), and the second is moderate to severe vaginal dryness.

Both of these uses are for postmenopausal women only. Osphena is not used in children or in women who are pregnant or may become pregnant.

Most-Reported Side Effects for Ospemifene

From FAERS, the FDA’s public side-effect reporting system (2,601 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hot flush 372 reports
Headache 209 reports
Muscle spasms 194 reports
Vaginal haemorrhage 150 reports
Vaginal discharge 134 reports
See full Ospemifene drug information
Keep checking

Other Drugs & Cade

Browse every other medication we’ve checked against Cade — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Cade against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Cade list.

See the full Cade interactions page
See every supplement checked against Ospemifene, ranked by severity
Evidence & sources

Cade References

The 5 references that drive our Cade monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  2. Koruk, S. T., Ozyilkan, E., Kaya, P., Colak, D., Donderici, O., and Cesaretli, Y. Juniper tar poisoning. Clin.Toxicol.(Phila) 2005;43(1):47-49. PubMed
  3. Achour S, Abourazzak S, Mokhtari A, et al. Juniper tar (cade oil) poisoning in new born after a cutaneous application. BMJ Case Reports 2011 Oct 28;2011. PubMed
  4. Skalli S, Chebat A, Badrane N, Bencheikh RS. Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012. Food Chem Toxicol 2014;64:81-5. PubMed
  5. Rahmani H, Leonhardt S, Beladdale D, et al. Severe acute lung oedema after rectal enema with cade oil (abstract). European Association of Poisons Centres and Clinical Toxicologists XXIV International Congress, Strasbourg, 2004. Clin Toxicol 2004;42(4):487

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cade and Ospemifene Together: Common Questions

Is it safe to take Cade with Ospemifene?
We do not list a known interaction between Cade and Ospemifene. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Cade and Ospemifene have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Cade and Ospemifene at the same time of day?
At least one FDA label for a product containing Ospemifene says to take it with food. If you take Cade on an empty stomach out of habit, keep them separate and take Ospemifene with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Ospemifene products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Ospemifene interact with any supplements?
Yes. Ospemifene has documented interactions with 155 supplements in our database — Cade is not one of them. The Ospemifene interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cade monograph Uses, safety profile, and every drug interaction in one place Ospemifene drug information The full plain-English guide to this medication Ospemifene supplement interactions Every supplement checked against Ospemifene, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ospemifene and Cade?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.