Caffeic Acid + Avibactam Sodium, Ceftazidime
Avibactam Sodium, Ceftazidime brand name: Avycaz.
Avibactam Sodium, Ceftazidime falls into 2 drug categories that Caffeic Acid can interact with; the most serious is rated moderate. Theoretically, caffeic acid might increase the levels and clinical effects of OAT3 substrates.
Read the full interaction reportCaffeic Acid and Avibactam Sodium, Ceftazidime
These two interact in 2 distinct ways. Each one is explained separately below.
Why Are There 2 Interactions?
Caffeic Acid interacts with whole categories of medication. Avibactam Sodium, Ceftazidime falls into 2 of those categories, so it can interact with Caffeic Acid in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES
1 of 2Why this applies to Avibactam Sodium, Ceftazidime
Avibactam Sodium, Ceftazidime falls under ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES — the group Caffeic Acid interacts with.
In vitro, caffeic acid inhibits OAT3. This drug transport protein is involved in renal tubular uptake of some drugs from the blood and then elimination in the urine. Inhibition of this transporters decreases renal elimination and increases drug levels in the body. Although caffeic acid inhibits OAT3 in vitro, the clinical significance of this in humans is not known.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist for Avycaz (ceftazidime and avibactam). Your kidneys clear this antibiotic out of your body, partly through a little transporter called OAT3 that pumps the drug into your urine. In lab dish studies, caffeic acid appears to block that transporter. In theory, if that pump slows down, more of the antibiotic could linger in your bloodstream a bit longer.
I want to be honest about how shaky this is. This comes only from test-tube research, not from people, so we truly don't know if it matters in real life. Everyday coffee or fruit almost certainly won't be an issue. If you're considering a concentrated caffeic acid supplement while on Avycaz (which is given in the hospital anyway), just mention it to your care team first.
- Uwai Y, Ozeki Y, Isaka T, et al. Inhibitory effect of caffeic acid on human organic anion transporters hOAT1 and hOAT3: a novel candidate for food-drug interaction. Drug Metab Pharmacokinet 2011;26:486-93. PubMed
ORGANIC ANION TRANSPORTER 1 (OAT1) SUBSTRATES
2 of 2Avibactam Sodium, Ceftazidime also falls under ORGANIC ANION TRANSPORTER 1 (OAT1) SUBSTRATES.
In vitro, caffeic acid inhibits OAT1. This drug transport protein is involved in renal tubular uptake of some drugs from the blood and then elimination in the urine. Inhibition of this transporter decreases renal elimination and increases drug levels in the body. Although caffeic acid inhibits OAT1 in vitro, the clinical significance of this in humans is not known.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist for Avycaz (ceftazidime with avibactam). Your kidneys use a little transporter called OAT1 to help move this antibiotic out of your blood and into your urine. In a test-tube setting, caffeic acid appears to block that transporter. If that same thing happened in people, the medicine could clear a bit more slowly and build up to higher levels in your body, which might increase the chance of side effects like nausea, diarrhea, or headache.
I want to be honest about how thin this evidence is. It comes only from lab studies, not from real patients, so we truly don't know if it matters in humans. Avycaz is also given in the hospital under close watch. Still, it's worth mentioning any supplements to your care team so they can keep an eye on things.
- Uwai Y, Ozeki Y, Isaka T, et al. Inhibitory effect of caffeic acid on human organic anion transporters hOAT1 and hOAT3: a novel candidate for food-drug interaction. Drug Metab Pharmacokinet 2011;26:486-93. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Caffeic Acid Also Interacts With Other Medications
Caffeic Acid has 176 moderate, 5 minor known drug interactions in our database — the Avibactam Sodium, Ceftazidime one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Caffeic Acid
We haven’t checked that one against Caffeic Acid yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Caffeic Acid. Pick one to open its full report.
See Every Supplement That Interacts With Avibactam Sodium, Ceftazidime
This page covers Caffeic Acid only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Avibactam Sodium, Ceftazidime page lists 37 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: African Wild Potato (moderate), Bacillus Coagulans (moderate), Bacillus Subtilis (moderate), Banderol (moderate) and Bifidobacterium Animalis Subsp. Lactis (moderate).
By severity: 36 moderate · 1 minor.
From our pharmacist’s overview on the Avibactam Sodium, Ceftazidime page
“Avycaz, the combination of ceftazidime and avibactam, is an intravenous antibiotic for serious infections, and its supplement list is calmer than that setting might suggest. None of the 37 ingredients on file carries a major rating; 36 are moderate and one is minor.”
Reviewed by 2 · Jul 18, 2026
Taking Caffeic Acid as Part of a Dietary Supplement Product? Check It for Interactions
We hold 20 real supplement products containing Caffeic Acid, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Caffeic Acid. Your product may carry other ingredients that interact with Avibactam Sodium, Ceftazidime too, on top of Caffeic Acid — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Caffeic Acid and Avibactam Sodium, Ceftazidime Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,177 of 1,452 supplements looked up here in the last 7 days
#2,685 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Caffeic Acid
What is Caffeic Acid?
- Antioxidant support
- General anti-inflammatory use
- Skin and sun protection (topical)
- Immune support
- Cancer-prevention interest (research stage)
Caffeic acid is a natural plant compound found in coffee, many fruits, vegetables, and herbs, and it is studied mainly for its antioxidant and anti-inflammatory properties. Most evidence comes from laboratory and animal research, so its benefits in people are not yet proven. If you want to take it as a supplement, talk with your pharmacist or doctor first.
About Ceftazidime and Avibactam Injection
What Is Ceftazidime and Avibactam Injection Used For?
Brand name: Avycaz
Avycaz (ceftazidime and avibactam) is used to treat three types of serious bacterial infections in adults and children at least 31 weeks gestational age: complicated intra-abdominal infections (cIAI), complicated urinary tract infections (cUTI) including pyelonephritis (a kidney infection), and hospital-acquired bacterial pneumonia or ventilator-associated bacterial pneumonia (HABP/VABP). All three of these infections must be caused by specific susceptible gram-negative bacteria for Avycaz to be effective.
When treating complicated intra-abdominal infections, Avycaz must be used together with metronidazole, another antibiotic. Avycaz is only meant for infections proven or strongly suspected to be caused by bacteria that it can actually fight — using it otherwise can lead to antibiotic resistance.
Other Drugs & Caffeic Acid
Browse every other medication we’ve checked against Caffeic Acid — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
176 interactions
- Diclofenac Sodium ›
- Ibuprofen ›
- Aspirin ›
- Naproxen ›
- Ranitidine ›
- Hydrochlorothiazide ›
- Ciprofloxacin ›
- Flurbiprofen ›
- Ceftazidime ›
- Diclofenac Potassium ›
- Indomethacin ›
- Salsalate ›
- Acyclovir ›
- Cephalexin ›
- Etodolac ›
- Famotidine ›
- Ketoprofen ›
- Meloxicam ›
- Methotrexate ›
- Cefadroxil ›
- Cefuroxime ›
- Cimetidine ›
- Probenecid ›
- Sulindac ›
- Tolmetin Sodium ›
- Cefaclor ›
- Celecoxib ›
- Cephradine ›
- Diclofenac Epolamine ›
- Ketorolac Tromethamine ›
- Nabumetone ›
- Nepafenac ›
- Pemetrexed ›
- Phenylbutazone ›
- Piroxicam ›
- Tenoxicam ›
- Tiaprofenic Acid ›
- Zidovudine ›
- Acetylsalicylic Acid ›
- Adefovir ›
- Baricitinib ›
- Bempedoic Acid ›
- Cefamandole ›
- Cefazolin ›
- Cefdinir ›
- Cefditoren Pivoxil ›
- Cefepime ›
- Cefixime ›
- Cefmetazole ›
- Cefonicid ›
- Cefoperazone ›
- Cefotaxime ›
- Cefotetan ›
- Cefoxitin ›
- Cefpodoxime Proxetil ›
- Cefprozil ›
- Ceftibuten ›
- Ceftizoxime ›
- Ceftriaxone ›
- Cephalothin ›
Showing 60 of 176 moderate interactions — see all 176 on the Caffeic Acid page.
5 interactions
No interaction 2,648 drugs checked — show the list
We also checked Caffeic Acid against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Rivaroxaban ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Tadalafil ›
- Clopidogrel ›
- Abemaciclib ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Tirzepatide ›
- Methamphetamine ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Lamotrigine ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Gabapentin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Amlodipine Besylate ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Diazepam ›
- Dapsone ›
- Candesartan Cilexetil ›
- Cyclopentolate ›
Showing the 60 most looked-up of 2,648 medications checked with no known interaction — see the full Caffeic Acid list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Avibactam Sodium, Ceftazidime Is Linked to Lower Levels of 7 Nutrients
Natural Medicines records Avibactam Sodium, Ceftazidime as a medicine that can lower these. This is not an interaction with Caffeic Acid — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Avibactam Sodium, Ceftazidime nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Caffeic Acid and Avibactam Sodium, Ceftazidime Together: Common Questions
Can you take Caffeic Acid with Avibactam Sodium, Ceftazidime?
Why are there 2 interactions listed for Caffeic Acid and Avibactam Sodium, Ceftazidime?
How serious is the Caffeic Acid and Avibactam Sodium, Ceftazidime interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.