Canthaxanthin + Naloxegol
Naloxegol brand name: Movantik.
We found no known interaction between Canthaxanthin and Naloxegol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Naloxegol states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Canthaxanthin and Naloxegol
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Naloxegol and Canthaxanthin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Canthaxanthin at all — not against Naloxegol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Canthaxanthin safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Naloxegol Products Have a Food Rule — Canthaxanthin Should Not Break It
At least one FDA label for a product containing Naloxegol says to take it on an empty stomach. Most supplements — Canthaxanthin included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Naloxegol on its own and move Canthaxanthin to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Naloxegol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
(2.1) Take on an empty stomach at least 1 hour prior to the first meal of the day or 2 hours after the meal.
From the Dosage and Administration section of the FDA label we read for Naloxegol — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Naloxegol Is Prescribed For, and What Canthaxanthin Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Naloxegol is a prescription medicine with approved uses on its FDA label. Canthaxanthin is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Naloxegol is prescribed for: Naloxegol treats opioid-induced constipation (OIC). That is constipation caused by taking opioid pain medicine. Movantik is used in adults with chronic non-cancer pain. This includes people with chronic pain from prior cancer or its treatment who do not need frequent (for example, weekly) opioid dose increases.
Canthaxanthin has been studied for:
-
Cancer studied, not established Canthaxanthin has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Canthaxanthin for cancer
Although there has been interest in using oral canthaxanthin for cancer, there is insufficient reliable information about the clinical effects of canthaxanthin for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Naloxegol on your own; if you are taking Canthaxanthin for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Naloxegol
This page covers Canthaxanthin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Naloxegol page lists 138 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 94 moderate · 41 minor.
From our pharmacist’s overview on the Naloxegol page
“Naloxegol (Movantik) relieves the constipation that opioids cause, and this is a list that deserves real care before you add anything from it. Nearly all of the trouble traces to a single enzyme, CYP3A4, which the body relies on to clear naloxegol.”
Reviewed by 2 · Jul 18, 2026
Taking Canthaxanthin as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1 real supplement products containing Canthaxanthin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Canthaxanthin. Even though Canthaxanthin itself has no known interaction with Naloxegol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Canthaxanthin and Naloxegol Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#971 of 1,452 supplements looked up here in the last 7 days
#1,596 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Canthaxanthin reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Canthaxanthin and Naloxegol records this page draws on were last updated October 6, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Canthaxanthin
What is Canthaxanthin?
- Skin coloring or 'tanning pills'
- Food and feed coloring (e.g., to color farmed fish/poultry)
- Antioxidant supplement
- Erythropoietic protoporphyria (light sensitivity, historical/medical use)
Canthaxanthin is a reddish-orange carotenoid pigment used mainly as a coloring agent and in 'tanning pills.' There is little good evidence it provides health benefits, and high doses have been linked to a serious eye problem called canthaxanthin retinopathy, so the tanning-pill use is widely discouraged.
Carotenoid pigment (synthetic or from sources like the mushroom Cantharellus cinnabarinus, certain algae, and crustaceans) · Oral tablets and capsules, often marketed as 'tanning pills'; also used as a food coloring additive
An interaction check asks whether these two react with each other — it does not ask whether Canthaxanthin is a good idea for someone in your situation. Here is what our Canthaxanthin record says about it on its own.
Canthaxanthin: dosing
There is no established, recommended supplement dose of canthaxanthin for any health condition, and the high doses once used for skin coloring are not considered safe. Given the known risks at high doses, most people are better off avoiding supplemental canthaxanthin entirely.
From our Canthaxanthin monograph — the full record covers uses, side effects and every documented interaction.
About Naloxegol
What Is Naloxegol Used For?
Brand name: Movantik
Naloxegol treats opioid-induced constipation (OIC). That is constipation caused by taking opioid pain medicine.
Movantik is used in adults with chronic non-cancer pain. This includes people with chronic pain from prior cancer or its treatment who do not need frequent (for example, weekly) opioid dose increases.
Other Drugs & Canthaxanthin
Browse every other medication we’ve checked against Canthaxanthin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Canthaxanthin against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Sertraline ›
- Losartan Potassium ›
- Rosuvastatin ›
- Acetaminophen ›
- Aspirin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Ibuprofen ›
- Warfarin Sodium ›
- Levothyroxine, Liothyronine ›
- Docusate ›
- Amlodipine Besylate ›
- Metformin ›
- Amitriptyline ›
- Prednisone ›
- Methamphetamine ›
- Tadalafil ›
- Amphetamine ›
- Semaglutide ›
- Lisdexamfetamine ›
- Sumatriptan ›
- Propranolol ›
- Hydroxyurea ›
- Valacyclovir ›
- Amoxicillin ›
- Lisinopril ›
- Methotrexate ›
- Bupropion ›
- Azithromycin ›
- Fluoxetine ›
- Doxycycline ›
- Pregabalin ›
- Gabapentin ›
- Acetaminophen, Aspirin, Caffeine ›
- Dextroamphetamine ›
- Naproxen ›
- Lamotrigine ›
- Clonazepam ›
- Bendamustine ›
- Quetiapine ›
- Acyclovir ›
- Buspirone ›
- Omeprazole ›
- Duloxetine ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Canthaxanthin list.
Canthaxanthin References
The 15 references that drive our Canthaxanthin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Jackson R. Quick suntan pills in Canada. J Am Acad Dermatol 1981;4:233. PubMed
- Lober CW. Canthaxanthin- the "tanning" pill. J Am Acad Dermatol 1985;13:660. PubMed
- Rock GA, Decary F, Cole RS. Orange plasma from tanning capsules. Lancet 1981;1:1419-20. PubMed
- Bluhm R, Branch R, Johnston P, Stein R. Aplastic anemia associated with canthaxanthin ingested for 'tanning' purposes. JAMA 1990;264:1141-2. DOI
- Harnois C, Samson J, Malenfant M, Rousseau A. Canthaxanthin retinopathy. Anatomic and funtional reversibility. Arch Ophthalmol 1989;107:538-40. DOI
- Herbert V. Canthaxanthin toxicity. Am J Clin Nutr 1991;53:573-4. DOI
- White GL Jr, Beesley R, Thiese SM, Murdock RT. Retinal crystals and oral tanning agents. Am Fam Physician 1988;37:125-6.
- Chang TS, Aylward W, Clarkson JG, Gass JD. Asymmetric canthaxanthin retinopathy. Am J Ophthalmol 1995;119:801-2. PubMed
- Leyon H, Ros AM, Nyberg S, Algvere P. Reversibility of canthaxanthin deposits within the retina. Acta Ophthalmol (Copenh) 1990;68:607-11. PubMed
- Espaillat A, Aiello LP, Arrigg PG, et al. Canthaxanthine retinopathy. Arch Ophthalmol 1999;117:412-3.. PubMed
- Suhonen, R. and Plosila, M. The effect of beta-carotene in combination with canthaxanthin, Ro 8-8427 (Phenoro), in treatment of polymorphous light eruptions. Dermatologica 1981;163(2):172-176. PubMed
- Gupta, A. K., Haberman, H. F., Pawlowski, D., Shulman, G., and Menon, I. A. Canthaxanthin. Int.J.Dermatol. 1985;24(8):528-532.
- Bareford, D., Cumberbatch, M., and Derrick, Tovey L. Plasma discolouration due to sun-tanning aids. Vox Sang. 1984;46(3):180-182. DOI
- Macdonald, K., Holti, G., and Marks, J. Is there a place for beta-carotene/canthaxanthin in photochemotherapy for psoriasis? Dermatologica 1984;169(1):41-46.
- Gunson, H. H., Merry, A. H., Britton, G., and Stratton, F. Detection of carotenoids in blood donors taking Orobronze: a cautionary note. Clin.Lab Haematol. 1984;6(3):287-292. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Canthaxanthin and Naloxegol Together: Common Questions
Is it safe to take Canthaxanthin with Naloxegol?
Do Canthaxanthin and Naloxegol have any of the same side effects?
Should I take Canthaxanthin and Naloxegol at the same time of day?
Are Canthaxanthin and Naloxegol used for the same thing?
Does Naloxegol interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.