Drug & supplement interaction

Canthaxanthin + Amphetamine

Amphetamine brand names: Dyanavel XR, Adensys XR-ODT, Mydayis, Adzenys ER.

No Known Interaction
Medically reviewed by · Updated October 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Canthaxanthin and Amphetamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Canthaxanthin and Amphetamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amphetamine and Canthaxanthin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Canthaxanthin at all — not against Amphetamine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Canthaxanthin safety at a glance

Canthaxanthin overall Use caution Generally fine in small food-coloring amounts, but high-dose supplements have been linked to eye and other problems.
Pregnancy Avoid Not enough safety data; avoid supplemental doses during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid supplemental use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amphetamine and Canthaxanthin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Canthaxanthin Itself Has Been Linked To

This is not an interaction — nothing below involves Amphetamine. It is the side-effect record for Canthaxanthin on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Canthaxanthin, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Anemia Worth acting on Additional detail

    “Orally, large amounts of canthaxanthin can cause orange-brown coloration of the skin, brick-red coloration of stools, orange discoloration of plasma, discolored body secretions, diarrhea, nausea, stomach cramps, dry and itchy skin, urticaria, welts, gold and yellow crystalline deposits around the macula of the retina, and hepatitis.”

    Canthaxanthin · Natural Medicines adverse-effect record, reported in anemia.

    6 sources cited
    1. 5632. Lober CW. Canthaxanthin- the "tanning" pill. J Am Acad Dermatol 1985;13:660. PubMed
    2. 5631. Jackson R. Quick suntan pills in Canada. J Am Acad Dermatol 1981;4:233. PubMed
    3. 5634. Rock GA, Decary F, Cole RS. Orange plasma from tanning capsules. Lancet 1981;1:1419-20. PubMed
    4. 5637. Herbert V. Canthaxanthin toxicity. Am J Clin Nutr 1991;53:573-4. DOI
    5. 5635. Bluhm R, Branch R, Johnston P, Stein R. Aplastic anemia associated with canthaxanthin ingested for 'tanning' purposes. JAMA 1990;264:1141-2. DOI
    6. 5636. Harnois C, Samson J, Malenfant M, Rousseau A. Canthaxanthin retinopathy. Anatomic and funtional reversibility. Arch Ophthalmol 1989;107:538-40. DOI
  • Hives / Liver problems Worth acting on Additional detail

    Recorded for Canthaxanthin in the same Natural Medicines adverse-effect record shown under Anemia above.

  • Itching / Stomach pain / Diarrhea / Nausea Additional detail

    Recorded for Canthaxanthin in the same Natural Medicines adverse-effect record shown under Anemia above.

Everything above comes from the Natural Medicines adverse-effect record for Canthaxanthin — expand a row for the licensed statement it rests on. We haven’t matched Amphetamine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Amphetamine.

From our Q&A

Questions About Canthaxanthin or Amphetamine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Canthaxanthin or Amphetamine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Amphetamine

This page covers Canthaxanthin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amphetamine page lists 130 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Bitter Orange (major), Brewer's Yeast (major) and Cowhage (major).

By severity: 16 major · 97 moderate · 17 minor.

From our pharmacist’s overview on the Amphetamine page

“Amphetamine (Dyanavel XR, Adzenys ER, Mydayis) is a prescription stimulant, usually taken for ADHD, and its interaction list is one to approach with genuine care. Of the 130 supplements and herbal ingredients on file, 16 carry a major rating, and many of those work the same way, either inhibiting monoamine oxidase, as yohimbe does, or…”

Reviewed by 2 · Jul 18, 2026

Open the Amphetamine interaction page

One more smart check

Taking Canthaxanthin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Canthaxanthin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Canthaxanthin. Even though Canthaxanthin itself has no known interaction with Amphetamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Canthaxanthin and Amphetamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Canthaxanthin
Steady interest

#839 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amphetamine
Top 1%

#23 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Canthaxanthin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Canthaxanthin and Amphetamine records this page draws on were last updated October 6, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Canthaxanthin

What is Canthaxanthin?

  • Skin coloring or 'tanning pills'
  • Food and feed coloring (e.g., to color farmed fish/poultry)
  • Antioxidant supplement
  • Erythropoietic protoporphyria (light sensitivity, historical/medical use)

Canthaxanthin is a reddish-orange carotenoid pigment used mainly as a coloring agent and in 'tanning pills.' There is little good evidence it provides health benefits, and high doses have been linked to a serious eye problem called canthaxanthin retinopathy, so the tanning-pill use is widely discouraged.

Carotenoid pigment (synthetic or from sources like the mushroom Cantharellus cinnabarinus, certain algae, and crustaceans) · Oral tablets and capsules, often marketed as 'tanning pills'; also used as a food coloring additive

An interaction check asks whether these two react with each other — it does not ask whether Canthaxanthin is a good idea for someone in your situation. Here is what our Canthaxanthin record says about it on its own.

Canthaxanthin: dosing

There is no established, recommended supplement dose of canthaxanthin for any health condition, and the high doses once used for skin coloring are not considered safe. Given the known risks at high doses, most people are better off avoiding supplemental canthaxanthin entirely.

From our Canthaxanthin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Canthaxanthin monograph & all interactions
Medication

About Amphetamine

What Is Amphetamine Used For?

Brand names: Dyanavel XR, Adensys XR-ODT, Mydayis, Adzenys ER

Amphetamine treats Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years and older. Adzenys XR-ODT, Dyanavel XR, and the amphetamine extended-release orally disintegrating tablet formulations are specifically approved for ADHD in this age group.

Amphetamine Sulfate tablets and Evekeo (amphetamine sulfate tablets) are also approved for narcolepsy (a sleep disorder causing uncontrollable daytime sleepiness) and as a short-term aid in a calorie-restricted weight-loss program for exogenous obesity (weight gain from external factors like overeating) in patients who have not responded to other approaches.

Most-Reported Side Effects for Amphetamine

From FAERS, the FDA’s public side-effect reporting system (50,216 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 3,508 reports
Nausea 3,143 reports
Headache 2,923 reports
Anxiety 2,703 reports
Toxicity to various agents 2,287 reports
See full Amphetamine drug information
Keep checking

Other Drugs & Canthaxanthin

Browse every other medication we’ve checked against Canthaxanthin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Canthaxanthin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Canthaxanthin list.

See the full Canthaxanthin interactions page
See every supplement checked against Amphetamine, ranked by severity
Evidence & sources

Canthaxanthin References

The 12 references that drive our Canthaxanthin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Jackson R. Quick suntan pills in Canada. J Am Acad Dermatol 1981;4:233. PubMed
  2. Lober CW. Canthaxanthin- the "tanning" pill. J Am Acad Dermatol 1985;13:660. PubMed
  3. Rock GA, Decary F, Cole RS. Orange plasma from tanning capsules. Lancet 1981;1:1419-20. PubMed
  4. Bluhm R, Branch R, Johnston P, Stein R. Aplastic anemia associated with canthaxanthin ingested for 'tanning' purposes. JAMA 1990;264:1141-2. DOI
  5. Harnois C, Samson J, Malenfant M, Rousseau A. Canthaxanthin retinopathy. Anatomic and funtional reversibility. Arch Ophthalmol 1989;107:538-40. DOI
  6. Herbert V. Canthaxanthin toxicity. Am J Clin Nutr 1991;53:573-4. DOI
  7. White GL Jr, Beesley R, Thiese SM, Murdock RT. Retinal crystals and oral tanning agents. Am Fam Physician 1988;37:125-6.
  8. Chang TS, Aylward W, Clarkson JG, Gass JD. Asymmetric canthaxanthin retinopathy. Am J Ophthalmol 1995;119:801-2. PubMed
  9. Leyon H, Ros AM, Nyberg S, Algvere P. Reversibility of canthaxanthin deposits within the retina. Acta Ophthalmol (Copenh) 1990;68:607-11. PubMed
  10. Espaillat A, Aiello LP, Arrigg PG, et al. Canthaxanthine retinopathy. Arch Ophthalmol 1999;117:412-3.. PubMed
  11. Bareford, D., Cumberbatch, M., and Derrick, Tovey L. Plasma discolouration due to sun-tanning aids. Vox Sang. 1984;46(3):180-182. DOI
  12. Gunson, H. H., Merry, A. H., Britton, G., and Stratton, F. Detection of carotenoids in blood donors taking Orobronze: a cautionary note. Clin.Lab Haematol. 1984;6(3):287-292. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Canthaxanthin and Amphetamine Together: Common Questions

Is it safe to take Canthaxanthin with Amphetamine?
We do not list a known interaction between Canthaxanthin and Amphetamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Amphetamine interact with any supplements?
Yes. Amphetamine has documented interactions with 130 supplements in our database — Canthaxanthin is not one of them. The Amphetamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Canthaxanthin monograph Uses, safety profile, and every drug interaction in one place Amphetamine drug information The full plain-English guide to this medication Amphetamine supplement interactions Every supplement checked against Amphetamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 12 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amphetamine and Canthaxanthin?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.