Drug & supplement interaction

Catuaba + Ospemifene

Ospemifene brand name: Osphena.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Catuaba and Ospemifene in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ospemifene states a food rule worth keeping to.

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Interaction report

Catuaba and Ospemifene

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ospemifene and Catuaba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Catuaba at all — not against Ospemifene, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Catuaba safety at a glance

Catuaba overall Not established Human safety data are very limited, so its long-term safety is not well established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data exist for nursing, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ospemifene and Catuaba? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Ospemifene’s Own FDA Label Lists

This is not an interaction — none of it involves Catuaba. These are the most notable effects listed in the ADVERSE REACTIONS section of Ospemifene’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • A stroke or mini-stroke Worth acting on
  • Blood clots Worth acting on
  • Bleeding or bruising Worth acting on mentioned in 5.8% of FDA reports for Ospemifene
  • A severe allergic reaction Worth acting on
  • Hives Worth acting on
  • An allergic reaction Worth acting on
  • Flushing mentioned in 14.3% of FDA reports for Ospemifene
  • Muscle pain mentioned in 7.5% of FDA reports for Ospemifene
  • Sweating
  • Itching

Showing the 10 most notable of 12 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Ospemifene. Read the label on DailyMed › Where a percentage is shown, it is the share of 2,601 voluntary FDA FAERS reports for Ospemifene that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Catuaba’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Catuaba side to compare — that is a limit of the record, not a statement that Catuaba has no side effects.

How to take them

Some Ospemifene Products Have a Food Rule — Catuaba Should Not Break It

At least one FDA label for a product containing Ospemifene says to take it with food. If you take Catuaba on an empty stomach out of habit, keep them separate — and take Ospemifene with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ospemifene products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

One tablet taken orally once daily with food.

From the Dosage and Administration section of the FDA label we read for Ospemifene — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Ospemifene

This page covers Catuaba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ospemifene page lists 155 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Tiratricol (major) and Acacia Rigidula (moderate).

By severity: 4 major · 112 moderate · 39 minor.

From our pharmacist’s overview on the Ospemifene page

“Women prescribed ospemifene (Osphena) for painful intercourse after menopause are often the same women reaching for St. John's wort for mood or grapefruit juice at breakfast, and both sit among the four major-rated interactions on this page, so the list deserves genuine care.”

Reviewed by 2 · Jul 18, 2026

Open the Ospemifene interaction page

One more smart check

Taking Catuaba as Part of a Dietary Supplement Product? Check It for Interactions

We hold 242 real supplement products containing Catuaba, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Catuaba. Even though Catuaba itself has no known interaction with Ospemifene, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Catuaba and Ospemifene Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Catuaba
Top half

#410 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ospemifene
Steady interest

#2,474 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Catuaba and Ospemifene records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Catuaba

What is Catuaba?

  • Low libido or sexual performance
  • Erectile difficulties
  • General energy and fatigue
  • Mood support
  • Aphrodisiac (traditional tonic)

Catuaba is a Brazilian herbal bark long used as a traditional aphrodisiac and energy tonic, but there is very little reliable human research to show it works for any health condition. Quality and contents of products vary widely, so talk with your pharmacist or doctor before trying it, and avoid it if you are pregnant or breastfeeding.

Bark (and sometimes stems) · Capsules, tea, liquid extracts and tinctures, powders, and as part of multi-herb blends

An interaction check asks whether these two react with each other — it does not ask whether Catuaba is a good idea for someone in your situation. Here is what our Catuaba record says about it on its own.

Catuaba: dosing

There is no established, standardized dose for catuaba. Because the species and strength of products vary, there is no reliable "correct" amount that research supports.If you choose to use catuaba, follow the directions on the product label and do not exceed the recommended amount. Starting low is sensible. A pharmacist can help you review the specific product you are considering and check whether it is a good fit for you.

From our Catuaba monograph — the full record covers uses, side effects and every documented interaction.

Read the full Catuaba monograph & all interactions
Medication

About Ospemifene

What Is Ospemifene Used For?

Brand name: Osphena

Osphena (ospemifene) is used to treat two specific symptoms of vulvar and vaginal atrophy — the thinning and drying of vaginal tissues that can happen after menopause. The first is moderate to severe dyspareunia (painful intercourse), and the second is moderate to severe vaginal dryness.

Both of these uses are for postmenopausal women only. Osphena is not used in children or in women who are pregnant or may become pregnant.

Most-Reported Side Effects for Ospemifene

From FAERS, the FDA’s public side-effect reporting system (2,601 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hot flush 372 reports
Headache 209 reports
Muscle spasms 194 reports
Vaginal haemorrhage 150 reports
Vaginal discharge 134 reports
See full Ospemifene drug information
Keep checking

Other Drugs & Catuaba

Browse every other medication we’ve checked against Catuaba — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Catuaba against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Catuaba list.

See the full Catuaba interactions page
See every supplement checked against Ospemifene, ranked by severity
Sources

Sources & How We Checked

We checked Catuaba against Ospemifene in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Catuaba monograph › Uses, safety, and every drug interaction in one place Ospemifene supplement interactions › Every supplement checked against Ospemifene, ranked by severity Ospemifene drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Catuaba and Ospemifene Together: Common Questions

Is it safe to take Catuaba with Ospemifene?
We do not list a known interaction between Catuaba and Ospemifene. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Catuaba and Ospemifene at the same time of day?
At least one FDA label for a product containing Ospemifene says to take it with food. If you take Catuaba on an empty stomach out of habit, keep them separate and take Ospemifene with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Ospemifene products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Ospemifene interact with any supplements?
Yes. Ospemifene has documented interactions with 155 supplements in our database — Catuaba is not one of them. The Ospemifene interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ospemifene and Catuaba?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.