Chelation Therapy Products + Granisetron
Granisetron brand names: Kytril, Sustol.
We found no known interaction between Chelation Therapy Products and Granisetron in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Granisetron states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Chelation Therapy Products and Granisetron
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Granisetron and Chelation Therapy Products in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Chelation Therapy Products safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Granisetron
Interactions in our licensed database are recorded against drug classes, not just single drug names. Granisetron is filed under 3 classifications — serotonergic drugs, serotonergic drugs, oral drugs. Chelation Therapy Products has documented interactions with 3 drug classes — the most serious being insulin (major), diuretic drugs (moderate) and warfarin (coumadin) (moderate) — and none of Granisetron’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Chelation Therapy Products Does Interact With Other Medications
Chelation Therapy Products has 13 major, 77 moderate known drug interactions in our database — Granisetron isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Chelation Therapy Products
We haven’t checked that one against Chelation Therapy Products yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Chelation Therapy Products. Pick one to open its full report.
Chelation Therapy Products in Pregnancy & Breastfeeding
When unregulated chelation therapy products are used orally or parentally or when prescription chelation therapy products are used for unproven indications and/or in unapproved doses or routes of administration. The American College of Medical Toxicology and The American Academy of Clinical Toxicology recommend against the unapproved use of chelation therapy products. Chelation therapy products can have teratogenic effects and result in severe side effects including dehydration, hypocalcemia, kidney failure, neurodevelopmental toxicity, and death.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Granisetron Products Have a Food Rule — Chelation Therapy Products Should Not Break It
At least one FDA label for a product containing Granisetron says to take it on an empty stomach. Most supplements — Chelation Therapy Products included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Granisetron on its own and move Chelation Therapy Products to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Granisetron products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Recommended Dosage ( 2.2 ): The recommended dosage in adults is 10 mg administered as a single subcutaneous injection at least 30 minutes before the start of emetogenic chemotherapy on Day 1.
From the Dosage and Administration section of the FDA label we read for Granisetron — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Granisetron Is Prescribed For, and What Chelation Therapy Products Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Granisetron is a prescription medicine with approved uses on its FDA label. Chelation Therapy Products is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Granisetron is prescribed for: Granisetron is used to prevent nausea and vomiting linked to emetogenic (nausea-causing) cancer chemotherapy — including high-dose cisplatin — and radiation therapy, including total body irradiation and fractionated abdominal radiation. Granisetron hydrochloride tablets and Granisol oral solution are approved for both the chemotherapy and radiation indications. Sancuso skin patch is approved for prevention of nausea and vomiting in adults receiving moderately and/or highly emetogenic chemotherapy regimens of up to 5 consecutive days. Granisetron hydrochloride injection (intravenous) is also used to prevent and treat postoperative nausea and vomiting in adults.
Read the rest of what Granisetron is prescribed for
Sustol (subcutaneous injection) is used in combination with other anti-nausea medicines in adults specifically for the prevention of acute and delayed nausea and vomiting associated with moderately emetogenic chemotherapy or anthracycline and cyclophosphamide combination chemotherapy regimens.
Chelation Therapy Products has been studied for:
-
Cancer studied, not established Chelation Therapy Products has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Chelation Therapy Products for cancer
Although there is interest in using oral chelation therapy products for cancer, there is insufficient reliable information about the clinical effects of chelation therapy products for this use.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Granisetron on your own; if you are taking Chelation Therapy Products for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Granisetron
This page covers Chelation Therapy Products only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Granisetron page lists 38 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Lithium (major), 5-htp (moderate), Acetyl-l-carnitine (moderate) and Ayahuasca (moderate).
By severity: 2 major · 25 moderate · 11 minor.
From our pharmacist’s overview on the Granisetron page
“Granisetron (Kytril, Sustol) blocks serotonin signals to stop nausea from chemotherapy and surgery, and this is a list that warrants real caution before you add a supplement to it. Most of the entries raise serotonin themselves, and stacking them on a serotonin-acting drug can push toward serotonin syndrome, a dangerous overload of tha…”
Reviewed by 2 · Jul 18, 2026
Where Chelation Therapy Products and Granisetron Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#839 of 1,452 supplements looked up here in the last 7 days
#2,012 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chelation Therapy Products reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chelation Therapy Products and Granisetron records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Chelation Therapy Products
What is Chelation Therapy Products?
- Heavy metal poisoning (lead, mercury, arsenic, iron)
- Marketed for heart and artery health
- Promoted for 'detoxification'
- Promoted for circulation problems
- Sometimes promoted for autism (not supported)
Chelation therapy uses binding agents (like EDTA, DMSA, or DMPS) that latch onto certain metals so the body can remove them. It is an FDA-approved, doctor-supervised treatment only for proven heavy metal poisoning; over-the-counter 'chelation' supplements and unsupervised IV chelation for heart disease or detox are not proven safe or effective and can be dangerous. Talk to your doctor or pharmacist before considering any chelation product.
Not applicable (synthetic and oral binding agents) · Intravenous (IV) infusions, oral capsules, suppositories, and sprays
An interaction check asks whether these two react with each other — it does not ask whether Chelation Therapy Products is a good idea for someone in your situation. Here is what our Chelation Therapy Products record says about it on its own.
Chelation Therapy Products: dosing
There is no safe "do-it-yourself" chelation dose. When chelation is medically needed for poisoning, the agent, dose, and schedule are chosen by a doctor based on the specific metal, blood levels, body weight, and kidney function, with close monitoring.Over-the-counter "chelation" supplements are not standardized, and their actual contents and strength are uncertain. We do not recommend self-dosing these products.If a product label gives directions, do not assume they are safe or effective.
From our Chelation Therapy Products monograph — the full record covers uses, side effects and every documented interaction.
About Granisetron
What Is Granisetron Used For?
Brand names: Kytril, Sustol
Granisetron is used to prevent nausea and vomiting linked to emetogenic (nausea-causing) cancer chemotherapy — including high-dose cisplatin — and radiation therapy, including total body irradiation and fractionated abdominal radiation. Granisetron hydrochloride tablets and Granisol oral solution are approved for both the chemotherapy and radiation indications. Sancuso skin patch is approved for prevention of nausea and vomiting in adults receiving moderately and/or highly emetogenic chemotherapy regimens of up to 5 consecutive days.
Granisetron hydrochloride injection (intravenous) is also used to prevent and treat postoperative nausea and vomiting in adults. Sustol (subcutaneous injection) is used in combination with other anti-nausea medicines in adults specifically for the prevention of acute and delayed nausea and vomiting associated with moderately emetogenic chemotherapy or anthracycline and cyclophosphamide combination chemotherapy regimens.
Other Drugs & Chelation Therapy Products
Browse every other medication we’ve checked against Chelation Therapy Products — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
13 interactions
77 interactions
- Hydrochlorothiazide ›
- Trichlormethiazide ›
- Bendroflumethiazide ›
- Metolazone ›
- Spironolactone ›
- Warfarin Sodium ›
- Acetazolamide ›
- Chlorthalidone ›
- Cyclothiazide ›
- Indapamide ›
- Mannitol ›
- Methyclothiazide ›
- Torsemide ›
- Ammonium Chloride ›
- Benzthiazide ›
- Bumetanide ›
- Chlorothiazide ›
- Ethacrynic Acid ›
- Furosemide ›
- Hydroflumethiazide ›
- Methazolamide ›
- Polythiazide ›
- Quinethazone ›
- Theobromine ›
- Urea ›
- Warfarin ›
- Hydrochlorothiazide, Triamterene ›
- Amiloride, Hydrochlorothiazide ›
- Hydrochlorothiazide, Methyldopa ›
- Hydrochlorothiazide, Reserpine ›
- Hydrochlorothiazide, Spironolactone ›
- Acetaminophen, Pamabrom, Pyrilamine ›
- Atenolol, Chlortalidone ›
- Chlorothiazide, Methyldopa ›
- Hydralazine, Hydrochlorothiazide, Reserpine ›
- Reserpine, Trichlormethiazide ›
- Bendroflumethiazide, Potassium ›
- Captopril, Hydrochlorothiazide ›
- Chlorthalidone, Clonidine ›
- Deserpidine, Hydrochlorothiazide ›
- Deserpidine, Methyclothiazide ›
- Furosemide, Potassium ›
- Hydralazine, Hydrochlorothiazide ›
- Hydrochlorothiazide, Lisinopril ›
- Hydroflumethiazide, Reserpine ›
- Acetaminophen, Caffeine, Pyrilamine ›
- Atenolol, Chlorthalidone ›
- Azilsartan, Chlorthalidone ›
- Benazepril, Hydrochlorothiazide ›
- Bendroflumethiazide, Nadolol ›
- Bendroflumethiazide, Rauwolfia Serpentina ›
- Bisoprolol, Hydrochlorothiazide ›
- Bumetanide, Potassium ›
- Caffeine, Potassium Salicylate, Salicylamide ›
- Candesartan Cilexetil, Hydrochlorothiazide ›
- Chlorothiazide, Reserpine ›
- Cryptenamine, Methyclothiazide ›
- Enalapril Maleate, Hydrochlorothiazide ›
- Fosinopril, Hydrochlorothiazide ›
- Guanethidine, Hydrochlorothiazide ›
Showing 60 of 77 moderate interactions — see all 77 on the Chelation Therapy Products page.
No interaction 2,739 drugs checked — show the list
We also checked Chelation Therapy Products against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,739 medications checked with no known interaction — see the full Chelation Therapy Products list.
Chelation Therapy Products References
The 21 references that drive our Chelation Therapy Products monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Grebe HB, Gregory PJ. Inhibition of warfarin anticoagulation associated with chelation therapy. Pharmacotherapy 2002;22:1067-9.. PubMed
- Grier MT, Meyers DG. So much writing, so little science: a review of 37 years literature on edetate sodium chelation therapy. Ann Pharmacother 1993;27:1504-9.
- Christensen K, Theilade D. Edta chelation therapy: an ethical problem. Med Hypotheses 1999;53:69-70. PubMed
- Lacy CF, Armstrong LL, Ingrim NB, et al. Drug Information Handbook. 6th ed. Hudson, OH:Lexi-Comp Inc 1998:439-41.
- Ellsworth AJ, Witt DM, Dugdale DC, et al. Medical Drug Reference. Saint Louis, MO: Mosby-Year Book Inc 1998:302-3.
- Fountain JS, Reith DM. Dangers of "EDTA". N Z Med J 2014;127:126-7.
- Lamas GA, Goertz C, Boineau R, et al. Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. JAMA 2013;309:1241-50. PubMed
- Russo PA, Banovic T, Wiese MD, et al. Systemic allergy to EDTA in local anesthetic and radiocontrast media. J Allergy Clin Immunol Pract 2014;2:225-9. PubMed
- Centers for Disease Control and Prevention (CDC). Deaths associated with hypocalcemia from chelation therapy--Texas, Pennsylvania, and Oregon, 2003-2005. MMWR Morb Mortal Wkly Rep 2006;55(8):204-7.
- Brown MJ, Willis T, Omalu B, Leiker R. Deaths resulting from hypocalcemia after administration of edetate disodium: 2003-2005. Pediatrics 2006;118(2):e534-6. PubMed
- Baxter AJ, Krenzelok EP. Pediatric fatality secondary to EDTA chelation. Clin Toxicol (Phila) 2008;46(10):1083-4. PubMed
- Atwood KC, Woeckner E. In pediatric fatality, edetate disodium was no accident. Clin Toxicol (Phila) 2009;47(3):256. PubMed
- James S, Stevenson SW, Silove N, Williams K. Chelation for autism spectrum disorder (ASD). Cochrane Database Syst Rev 2015;5(5):CD010766. PubMed
- Lamas GA, Hussein SJ. EDTA chelation therapy meets evidence-based medicine. Complement Ther Clin Pract 2006;12(3):213-5. PubMed
- Villarruz MV, Dans A, Tan F. Chelation therapy for atherosclerotic cardiovascular disease. Cochrane Database Syst Rev 2002;(4):CD002785. PubMed
- Knudtson ML, Wyse DG, Galbraith PD, et al. Chelation therapy for ischemic heart disease: a randomized controlled trial. JAMA. 2002;287(4):481-6. PubMed
- Wax PM. Current use of chelation in American health care. J Med Toxicol 2013;9(4):303-7. PubMed
- American College of Medical Toxicology and The American Academy of Clinical Toxicology. https://www.choosingwisely.org/clinician-lists/american-college-academy-medical-toxicology-chelation/. Accessed May 18, 2022.
- Food and Drug Administration. Questions and answers on unapproved chelation products. https://www.fda.gov/drugs/medication-health-fraud/questions-and-answers-unapproved-chelation-products. Accessed May 18, 2022.
- Van der Linde AAA, Pillen S, Gerrits GPJM, Bouwes Bavinck JN. Stevens-Johnson syndrome in a child with chronic mercury exposure and 2,3-dimercaptopropane-1-sulfonate (DMPS) therapy. Clin Toxicol (Phila). 2008;46(5):479-81. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Chelation Therapy Products and Granisetron Together: Common Questions
Is it safe to take Chelation Therapy Products with Granisetron?
Do Chelation Therapy Products and Granisetron have any of the same side effects?
Should I take Chelation Therapy Products and Granisetron at the same time of day?
Are Chelation Therapy Products and Granisetron used for the same thing?
How was the Chelation Therapy Products and Granisetron combination checked?
Does Chelation Therapy Products interact with any other medications?
Does Granisetron interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.