Drug & supplement interaction

Chenopodium Oil + Pegloticase

Pegloticase brand name: Krystexxa.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Chenopodium Oil and Pegloticase in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Chenopodium Oil and Pegloticase

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pegloticase and Chenopodium Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chenopodium Oil safety at a glance

Chenopodium Oil overall Avoid The oil contains ascaridole, which is toxic and has a narrow margin between an effective and a dangerous dose.
Pregnancy Avoid It may stimulate the uterus and is potentially toxic, so it should not be used during pregnancy.
Breastfeeding Unsafe When used orally due to toxicity. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pegloticase and Chenopodium Oil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pegloticase

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pegloticase is filed under a single classification — antigout drugs. Chenopodium Oil has documented interactions with 1 drug class — the most serious being photosensitizing drugs (moderate) — and none of Pegloticase’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Chenopodium Oil Does Interact With Other Medications

Chenopodium Oil has 335 moderate known drug interactions in our database — Pegloticase isn’t one of them. If you take anything else, check it against the full list below.

Moderate 335 No known interaction 2,495 (incl. Pegloticase)
Taking anything else?

Check Another of Your Medications Against Chenopodium Oil

Covers the 2,830 medications we’ve checked against Chenopodium Oil. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Chenopodium Oil and Pegloticase May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting Additional detail

    Chenopodium Oil

    “Orally, chenopodium oil can cause vomiting (11).”

    Chenopodium Oil · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

    Pegloticase

    Listed in the ADVERSE REACTIONS section of the FDA label for Pegloticase. Read the label on DailyMed ›

Reported for Chenopodium Oil but not commonly for Pegloticase: liver problems, seizures, dizziness and headache.

Effects for Pegloticase come from the ADVERSE REACTIONS section of its FDA label; effects for Chenopodium Oil come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 3,424 voluntary FDA FAERS reports for Pegloticase that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Chenopodium Oil in Pregnancy & Breastfeeding

Lactation Unsafe

When used orally due to toxicity.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Pegloticase

This page covers Chenopodium Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pegloticase page lists 1 supplement it has a documented interaction with, worst first, each one explained.

The most serious there right now: Inosine (moderate).

By severity: 1 moderate.

From our pharmacist’s overview on the Pegloticase page

“Inosine is the one supplement on record that can work against pegloticase (Krystexxa), the IV enzyme infused for severe gout that has stopped responding to standard treatment. Inosine raises uric acid in the blood and urine, which is precisely what pegloticase exists to lower, so combining the two could blunt the very benefit those inf…”

Reviewed by 2 · Jul 18, 2026

Open the Pegloticase interaction page

One more smart check

Taking Chenopodium Oil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Chenopodium Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chenopodium Oil. Even though Chenopodium Oil itself has no known interaction with Pegloticase, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chenopodium Oil and Pegloticase Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chenopodium Oil
Top half

#618 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pegloticase
Steady interest

#2,188 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chenopodium Oil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Chenopodium Oil and Pegloticase records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chenopodium Oil

What is Chenopodium Oil?

Chenopodium Oil
  • Intestinal worms (roundworm, hookworm)
  • Digestive upset and gas
  • Respiratory complaints
  • Skin conditions
  • As a culinary seasoning (epazote leaf)

Chenopodium oil is a strong-smelling essential oil from the epazote plant that was historically used to treat intestinal worms. It contains ascaridole, a compound that is quite toxic, and overdoses have caused serious harm, so it is no longer recommended for internal use. Safer modern deworming medicines exist, so talk with a pharmacist or doctor before using this oil.

Dysphania ambrosioides · Amaranthaceae · Essential oil from the leaves and seeds · Essential oil; sometimes the leaf is used as a tea or culinary herb (epazote)

An interaction check asks whether these two react with each other — it does not ask whether Chenopodium Oil is a good idea for someone in your situation. Here is what our Chenopodium Oil record says about it on its own.

Chenopodium Oil: dosing

There is no safe, established dose of chenopodium oil for any condition, and it is not recommended for self-treatment. For intestinal worms, safer and more effective prescription and over-the-counter medicines are available.

From our Chenopodium Oil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chenopodium Oil monograph & all interactions
Medication

About Pegloticase Injection

What Is Pegloticase Injection Used For?

Brand name: Krystexxa

Krystexxa is used to treat chronic gout in adults whose gout has not responded to conventional treatments — either because standard uric-acid-lowering medications (like xanthine oxidase inhibitors) haven't brought uric acid to a normal level, or because those drugs cannot be used.

Krystexxa is not recommended for people who have high uric acid levels but no gout symptoms (a condition called asymptomatic hyperuricemia).

Most-Reported Side Effects for Pegloticase

From FAERS, the FDA’s public side-effect reporting system (3,686 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Gout 562 reports
Blood uric acid increased 405 reports
Infusion related reaction 365 reports
Therapeutic response decreased 240 reports
Dyspnea 180 reports
See full Pegloticase Injection drug information
Keep checking

Other Drugs & Chenopodium Oil

Browse every other medication we’ve checked against Chenopodium Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
335Moderate
0Minor
2,494No known interaction
335 Moderate 2,494 No interaction
Moderate

335 interactions

Showing 60 of 335 moderate interactions — see all 335 on the Chenopodium Oil page.

No interaction 2,494 drugs checked — show the list

We also checked Chenopodium Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,494 medications checked with no known interaction — see the full Chenopodium Oil list.

See the full Chenopodium Oil interactions page
See every supplement checked against Pegloticase, ranked by severity
Evidence & sources

Chenopodium Oil References

The 2 references that drive our Chenopodium Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chenopodium Oil and Pegloticase Together: Common Questions

Is it safe to take Chenopodium Oil with Pegloticase?
We do not list a known interaction between Chenopodium Oil and Pegloticase. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Chenopodium Oil and Pegloticase have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Chenopodium Oil and Pegloticase combination checked?
Interactions in our licensed database are recorded against drug classes. Pegloticase is filed under 1 classification, and Chenopodium Oil has documented interactions with 1 drug class — none of Pegloticase's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Chenopodium Oil interact with any other medications?
Yes. Chenopodium Oil has 335 documented drug interactions in our database — Pegloticase is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pegloticase interact with any supplements?
Yes. Pegloticase has documented interactions with 1 supplement in our database — Chenopodium Oil is not one of them. The Pegloticase interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chenopodium Oil monograph Uses, safety profile, and every drug interaction in one place Pegloticase Injection drug information The full plain-English guide to this medication Pegloticase supplement interactions Every supplement checked against Pegloticase, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pegloticase and Chenopodium Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.