Drug & supplement interaction

Chinese Cucumber + Simvastatin, Sitagliptin

Simvastatin, Sitagliptin brand name: Juvisync.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Chinese Cucumber has a moderate interaction with Simvastatin, Sitagliptin. Theoretically, concomitant use of Chinese cucumber with antidiabetic drugs may have additive effects and adverse effects.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Chinese Cucumber and Simvastatin, Sitagliptin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Simvastatin, Sitagliptin

Simvastatin, Sitagliptin falls under ANTIDIABETES DRUGS — the group Chinese Cucumber interacts with.

Theoretically, concomitant use of Chinese cucumber with antidiabetic drugs may have additive effects and adverse effects. Monitor blood glucose levels closely, dose adjustment may be needed.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

The combo pill Juvisync pairs sitagliptin (which helps lower blood sugar) with simvastatin (a cholesterol medicine). The concern here is really about the sitagliptin side. Chinese cucumber has been looked at for possibly nudging blood sugar downward, so the worry is that it could add to sitagliptin's glucose-lowering work and push your numbers too low.

To be honest, this is a theoretical caution based on lab and animal data, not solid human studies, so I wouldn't panic. Still, keep an eye out for signs of low blood sugar like shakiness, sweating, dizziness, or feeling foggy, and check your levels more often if you start it. Please loop in your pharmacist or doctor before adding this one.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Hikino H, Yoshizawa M, Suzuki Y, et al. Isolation and hypoglycemic activity of trichosans A, B, C, D, and E: glycans of Trichosanthes kirilowii roots. Planta Med 1989;55:349-50.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Chinese Cucumber Also Interacts With Other Medications

Chinese Cucumber has 85 moderate known drug interactions in our database — the Simvastatin, Sitagliptin one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Simvastatin, Sitagliptin)
Taking anything else?

Check Another of Your Medications Against Chinese Cucumber

Covers the 2,830 medications we’ve checked against Chinese Cucumber. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Simvastatin, Sitagliptin

This page covers Chinese Cucumber only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Simvastatin, Sitagliptin page lists 362 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Beer (major), Grapefruit (major) and Siberian Cocklebur (major).

By severity: 8 major · 304 moderate · 50 minor.

From our pharmacist’s overview on the Simvastatin, Sitagliptin page

“Juvisync pairs simvastatin for cholesterol with sitagliptin for type 2 diabetes, and that combination carries 362 supplement interactions on file, eight rated major, so read this page with real care rather than a quick skim. Grapefruit stands out as the everyday hazard; it blocks the enzyme that clears simvastatin, raising statin level…”

Reviewed by 2 · Jul 18, 2026

Open the Simvastatin, Sitagliptin interaction page

One more smart check

Taking Chinese Cucumber as Part of a Dietary Supplement Product? Check It for Interactions

We hold 16 real supplement products containing Chinese Cucumber, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chinese Cucumber. Your product may carry other ingredients that interact with Simvastatin, Sitagliptin too, on top of Chinese Cucumber — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chinese Cucumber and Simvastatin, Sitagliptin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chinese Cucumber
Steady interest

#1,444 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Simvastatin, Sitagliptin
Top half

#770 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Chinese Cucumber

What is Chinese Cucumber?

Chinese Cucumber
  • Cough and chest congestion
  • Constipation
  • Diabetes (traditional use)
  • Fever and inflammation
  • Investigational HIV use (trichosanthin)

Chinese cucumber (Trichosanthes kirilowii) is a plant used in traditional Chinese medicine, and a protein from its root called trichosanthin (Compound Q) has been studied as an injectable drug—not a casual supplement. Reliable human evidence for its supplement uses is very limited, and the purified protein has caused serious, even life-threatening, reactions. Talk to your pharmacist or doctor before using it.

Read the full Chinese Cucumber monograph & all interactions
Keep checking

Other Drugs & Chinese Cucumber

Browse every other medication we’ve checked against Chinese Cucumber — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Chinese Cucumber page.

No interaction 2,744 drugs checked — show the list

We also checked Chinese Cucumber against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Chinese Cucumber list.

See the full Chinese Cucumber interactions page
See every supplement checked against Simvastatin, Sitagliptin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Chinese Cucumber monograph › Uses, safety, and every drug interaction in one place Simvastatin, Sitagliptin supplement interactions › Every supplement checked against Simvastatin, Sitagliptin, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Chinese Cucumber and Simvastatin, Sitagliptin Together: Common Questions

Can you take Chinese Cucumber with Simvastatin, Sitagliptin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Chinese Cucumber and Simvastatin, Sitagliptin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Simvastatin, Sitagliptin and Chinese Cucumber?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.