Medication interaction hub

What Supplements Interact with Simvastatin, Sitagliptin?

Simvastatin, Sitagliptin brand name: Juvisync. Every interaction below applies to the brands too.

362 Interactions 8 Major 304 Moderate 50 Minor
Curated & coded by · Clinical Pharmacist · Updated September 16, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Simvastatin, Sitagliptin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Simvastatin, Sitagliptin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Juvisync pairs simvastatin for cholesterol with sitagliptin for type 2 diabetes, and that combination carries 362 supplement interactions on file, eight rated major, so read this page with real care rather than a quick skim. Grapefruit stands out as the everyday hazard; it blocks the enzyme that clears simvastatin, raising statin levels and the odds of side effects like muscle pain. And 239 of these ingredients can shift your blood sugar, most often nudging it lower on top of sitagliptin.

Most of those blood sugar entries are moderate, part of the 304 moderates on this list alongside 50 minors, and closer glucose checks handle many of them. The eight majors ask more of you. Heavy alcohol and Siberian cocklebur strain the liver, apple and orange juice can cut how much of your dose gets absorbed, and St. John's wort speeds the statin's breakdown so it may work less well. Space those juices well away from your pills, and know the remaining majors by name.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 304 Minor 50 No known interaction 1,090

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Simvastatin, Sitagliptin: Top Interactions at a Glance

The most significant Simvastatin, Sitagliptin supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 362 interacting ingredients — plus 1,090 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Simvastatin, Sitagliptin + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Apple + Simvastatin, Sitagliptini

Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.

Read the full interaction Major Likelihood Likely Grapefruit + Simvastatin, Sitagliptini

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Simvastatin, Sitagliptini

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Likely Sweet Orange + Simvastatin, Sitagliptini

Consuming sweet orange juice can decrease oral absorption of OATP substrates.

Read the full interaction Major Likelihood Probable Activated Charcoal + Simvastatin, Sitagliptini

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Simvastatin, Sitagliptini

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Simvastatin, Sitagliptin

All 1,452 ingredients in our database, ranked by severity — 362 with a Simvastatin, Sitagliptin interaction on file and 1,090 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Simvastatin, Sitagliptin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Buchu with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu contains pulegone, a known hepatotoxin.

Full Buchu + Simvastatin, Sitagliptin answer

Can you take Bulbine Natalensis with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Simvastatin, Sitagliptin answer

Can you take Bupleurum with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bupleurum might decrease the effects of antidiabetes drugs.

Full Bupleurum + Simvastatin, Sitagliptin answer

Can you take Caffeic Acid with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeic acid might increase the levels and clinical effects of OAT1 substrates.

Full Caffeic Acid + Simvastatin, Sitagliptin answer

Can you take Cajeput Oil with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal studies suggest that cajeput oil might have hypoglycemic effects.

Full Cajeput Oil + Simvastatin, Sitagliptin answer

Can you take Calamus with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Simvastatin, Sitagliptin answer

Can you take Calcium D-glucarate with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.

Full Calcium D-glucarate + Simvastatin, Sitagliptin answer

Can you take Camphor with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.

Full Camphor + Simvastatin, Sitagliptin answer

Can you take Cannabis with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Full Cannabis + Simvastatin, Sitagliptin answer

Can you take Capers with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glyc...

Full Capers + Simvastatin, Sitagliptin answer

Can you take Capsicum with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.

Full Capsicum + Simvastatin, Sitagliptin answer

Can you take Caraway with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caraway might increase the risk of hypoglycemia when used with antidiabetes drugs.

Full Caraway + Simvastatin, Sitagliptin answer

Can you take Carnosine with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking carnosine with antidiabetes drugs might increase the risk of hypoglycemia.

Full Carnosine + Simvastatin, Sitagliptin answer

Can you take Carqueja with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, carqueja might lower blood glucose levels and might have additive effects when used with antidiabetes drugs.

Full Carqueja + Simvastatin, Sitagliptin answer

Can you take Cashew with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Eating a diet that consists of high amounts of cashew might increase fasting blood glucose levels.

Full Cashew + Simvastatin, Sitagliptin answer

Can you take Cassia Auriculata with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Cassia auriculata may reduce blood glucose levels and might have additive effects on glucose levels when used with antidiabet...

Full Cassia Auriculata + Simvastatin, Sitagliptin answer

Can you take Cassia Cinnamon with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Cassia Cinnamon + Simvastatin, Sitagliptin answer

Can you take Cat's Claw with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Full Cat's Claw + Simvastatin, Sitagliptin answer

Can you take Ceylon Cinnamon with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.

Full Ceylon Cinnamon + Simvastatin, Sitagliptin answer

Can you take Ceylon Leadwort with Simvastatin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Ceylon Leadwort + Simvastatin, Sitagliptin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Simvastatin, Sitagliptin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Simvastatin, Sitagliptin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Simvastatin, Sitagliptin sits in 10 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Simvastatin, Sitagliptin through this category.

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Simvastatin, Sitagliptin through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Simvastatin, Sitagliptin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Simvastatin, Sitagliptin through this category.

Organic Anion-Transporting Polypeptide Substrates (Oatp) 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Simvastatin, Sitagliptin through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Simvastatin, Sitagliptin through this category.

Hmg-Coa Reductase Inhibitors ("Statins") 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Simvastatin, Sitagliptin through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Simvastatin, Sitagliptin through this category.

Simvastatin (Zocor) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Simvastatin, Sitagliptin through this category.

Sitagliptin (Januvia) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Simvastatin, Sitagliptin through this category.

Related: does Simvastatin, Sitagliptin deplete any nutrients?

Simvastatin, Sitagliptin has 3 reported nutrient associations in the research literature — see the Simvastatin, Sitagliptin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Simvastatin, Sitagliptin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Simvastatin, Sitagliptin.

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Pharmacist Counseling Corner

Simvastatin, Sitagliptin & Supplements: Common Questions

What supplements interact with Simvastatin, Sitagliptin?
Our database currently documents 362 ingredients with a known Simvastatin, Sitagliptin interaction (8 major, 304 moderate, 50 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 362. The highest-ranked right now: Apple, Grapefruit, Siberian Cocklebur.
Which Simvastatin, Sitagliptin supplement interactions are the most serious?
The 8 major-rated combinations — led by Apple, Grapefruit, Siberian Cocklebur, Sweet Orange and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Simvastatin, Sitagliptin?
Plenty of supplements coexist fine with Simvastatin, Sitagliptin; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Juvisync have the same supplement interactions as Simvastatin, Sitagliptin?
Yes — Juvisync all contain Simvastatin, Sitagliptin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Simvastatin, Sitagliptin deplete any vitamins or nutrients?
It might — Simvastatin, Sitagliptin has 3 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Simvastatin, Sitagliptin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Simvastatin, Sitagliptin and my other medications?
This page covers Simvastatin, Sitagliptin against supplements and herbal ingredients. Checking Simvastatin, Sitagliptin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 16, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.