Drug & supplement interaction

Clary Sage + Methyldopa

Methyldopa brand names: Aldomet, Methyldopa.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Clary Sage and Methyldopa in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Clary Sage and Methyldopa

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methyldopa and Clary Sage in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Clary Sage at all — not against Methyldopa, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Clary Sage safety at a glance

Clary Sage overall Use caution Generally considered safe as a diluted essential oil for aromatherapy, but it should not be taken by mouth.
Pregnancy Avoid Often discouraged in pregnancy because it is traditionally linked to uterine activity, so avoid it.
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methyldopa and Clary Sage? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Methyldopa’s Own FDA Label Lists

This is not an interaction — none of it involves Clary Sage. These are the most notable effects listed in the ADVERSE REACTIONS section of Methyldopa’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • A slow heartbeat Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Heart failure Worth acting on
  • A severe skin reaction Worth acting on
  • Chest pain Worth acting on
  • Low mood Worth acting on
  • A low platelet count Worth acting on
  • Anemia Worth acting on
  • A low white blood cell count Worth acting on

Showing the 10 most notable of 33 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Methyldopa. Read the label on DailyMed › Where a percentage is shown, it is the share of 4,840 voluntary FDA FAERS reports for Methyldopa that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Clary Sage’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Clary Sage side to compare — that is a limit of the record, not a statement that Clary Sage has no side effects.

From our Q&A

Questions About Clary Sage or Methyldopa

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Clary Sage or Methyldopa, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Methyldopa

This page covers Clary Sage only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methyldopa page lists 173 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Beer (major) and Cowhage (major).

By severity: 8 major · 144 moderate · 21 minor.

From our pharmacist’s overview on the Methyldopa page

“Alcohol is the entry I would read first. Methyldopa (Aldomet) can be hard on the liver by itself, and 38 of the 173 supplement and herbal ingredients here, beer and wine included, carry liver risks that could stack on top of that.”

Reviewed by 2 · Jul 18, 2026

Open the Methyldopa interaction page

One more smart check

Taking Clary Sage as Part of a Dietary Supplement Product? Check It for Interactions

We hold 31 real supplement products containing Clary Sage, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Clary Sage. Even though Clary Sage itself has no known interaction with Methyldopa, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Clary Sage and Methyldopa Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Clary Sage
Steady interest

#1,288 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methyldopa
Top half

#943 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Clary Sage reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Clary Sage and Methyldopa records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Clary Sage

What is Clary Sage?

  • Stress and anxiety
  • Menstrual cramps
  • Menopause symptoms
  • Aromatherapy and relaxation
  • Skin care

Clary sage is a Mediterranean herb most often used as an essential oil for aromatherapy and to ease stress or menstrual discomfort. Evidence for these uses is limited and mostly from small studies, and the oil should never be swallowed and should always be diluted before skin contact.

Salvia sclarea · Lamiaceae · Flowering tops and leaves (essential oil) · Essential oil, aromatherapy blends, diluted topical oils

An interaction check asks whether these two react with each other — it does not ask whether Clary Sage is a good idea for someone in your situation. Here is what our Clary Sage record says about it on its own.

Clary Sage: dosing

There is no official or standardized dose for clary sage, and it is not meant to be taken by mouth as a supplement.For aromatherapy, people typically add a few drops to a diffuser or dilute a small amount in a carrier oil before applying it to the skin.

From our Clary Sage monograph — the full record covers uses, side effects and every documented interaction.

Read the full Clary Sage monograph & all interactions
Medication

About Methyldopa

What Is Methyldopa Used For?

Brand names: Aldomet, Methyldopa

Methyldopa tablets are used to treat high blood pressure (hypertension) in adults and children. Lowering blood pressure reduces the risk of complications that come with uncontrolled hypertension.

Most-Reported Side Effects for Methyldopa

From FAERS, the FDA’s public side-effect reporting system (4,840 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Foetal exposure during pregnancy 1,326 reports
Premature baby 913 reports
Premature delivery 577 reports
Low birth weight baby 382 reports
Hypertension 258 reports
See full Methyldopa drug information
Keep checking

Other Drugs & Clary Sage

Browse every other medication we’ve checked against Clary Sage — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Clary Sage against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Clary Sage list.

See the full Clary Sage interactions page
See every supplement checked against Methyldopa, ranked by severity
Evidence & sources

Clary Sage References

The 2 references that drive our Clary Sage monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ou, M. C., Hsu, T. F., Lai, A. C., Lin, Y. T., and Lin, C. C. Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial. J Obstet.Gynaecol.Res 2012;38(5):817-822. PubMed
  2. Amirhosseini M, Dehghan M, Mangolian Shahrbabaki P, Pakmanesh H. Effectiveness of aromatherapy for relief of pain, nausea, and vomiting after percutaneous nephrolithotomy: a randomized controlled trial. Complement Med Res 2020:1-9. Online ahead of print. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Clary Sage and Methyldopa Together: Common Questions

Is it safe to take Clary Sage with Methyldopa?
We do not list a known interaction between Clary Sage and Methyldopa. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Methyldopa interact with any supplements?
Yes. Methyldopa has documented interactions with 173 supplements in our database — Clary Sage is not one of them. The Methyldopa interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Clary Sage monograph Uses, safety profile, and every drug interaction in one place Methyldopa drug information The full plain-English guide to this medication Methyldopa supplement interactions Every supplement checked against Methyldopa, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Methyldopa and Clary Sage?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.