Drug & supplement interaction

Coleus + Liraglutide Recombinant

Liraglutide Recombinant brand name: Saxenda.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Coleus and Liraglutide Recombinant in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Coleus and Liraglutide Recombinant

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Liraglutide Recombinant and Coleus in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Coleus safety at a glance

Coleus overall Use caution May lower blood pressure and is not well studied for long-term use, so use with care and professional guidance.
Pregnancy Possibly Unsafe When used orally. Evidence from animal research suggests that high doses of coleus can inhibit embryo implantation and/or delay fetal development; avoid using. Read the full pregnancy detail
Breastfeeding Avoid Not enough safety data; avoid use while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Liraglutide Recombinant and Coleus? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Liraglutide Recombinant

Interactions in our licensed database are recorded against drug classes, not just single drug names. Liraglutide Recombinant is filed under a single classification — antidiabetes drugs. Coleus has documented interactions with 7 drug classes — the most serious being calcium channel blockers (major), nitrates (major) and anticoagulant/antiplatelet drugs (moderate) — and none of Liraglutide Recombinant’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Coleus Does Interact With Other Medications

Coleus has 29 major, 886 moderate known drug interactions in our database — Liraglutide Recombinant isn’t one of them. If you take anything else, check it against the full list below.

Major 29 Moderate 886 No known interaction 1,915 (incl. Liraglutide Recombinant)
Taking anything else?

Check Another of Your Medications Against Coleus

Covers the 2,830 medications we’ve checked against Coleus. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Coleus and Liraglutide Recombinant May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Cough Additional detail

    Coleus

    “Inhalation of forskolin, a constituent of coleus, can cause throat and upper respiratory tract irritation, and mild to moderate cough.”

    Coleus · Natural Medicines adverse-effect record, reported in cough.

    1 source cited
    1. 7281. Bauer K, Dietersdorfer F, Kaspar S, et al. Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma. Clin Pharmacol Ther 1993;53:76-83. PubMed

    Liraglutide Recombinant

    Listed in the ADVERSE REACTIONS section of the FDA label for Liraglutide Recombinant. Read the label on DailyMed ›

  • Anxiety or restlessness Additional detail

    Coleus

    “Orally, intravenously, ophthalmologically, and by inhalation, coleus seems to be well tolerated.

    Most Common Adverse Effects:

    Orally: Constipation, diarrhea, nausea, vomiting.

    Intravenously: Flushing, hypotension, tachycardia.

    Ophthalmologically: Conjunctival hyperemia, stinging eyes.

    Inhalation: Irritation of the respiratory tract, restlessness, tremor.”

    Coleus · Natural Medicines adverse-effect record, reported in constipation.

    Liraglutide Recombinant

    Listed in the ADVERSE REACTIONS section of the FDA label for Liraglutide Recombinant. Read the label on DailyMed ›

  • Constipation / Diarrhea / Vomiting / Nausea Additional detail

    Coleus

    “Orally, coleus can cause dose-related diarrhea and other gastrointestinal symptoms. Increased bowel movements and loose stools have been reported in 1 of 15 patients taking coleus extract in a clinical trial. Some retrospective evidence reports about a 10% rate of gastrointestinal adverse effects from oral coleus use; 81% of these adverse effects were related to diarrhea.”

    Coleus · Natural Medicines adverse-effect record, reported in constipation.

    2 sources cited
    1. 91885. Loftus HL, Astell KJ, Mathai ML, et al. Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial. Nutrients. 2015;7(11): PubMed
    2. 100851. Nishijima C, Chiba T, Sato Y, Umegaki K. Nationwide Online Survey Enables the Reevaluation of the Safety of Coleus forskohlii Extract Intake Based on the Adverse Event Frequencies. Nutrients. 2019;11(4). pii: E866. PubMed

    Liraglutide Recombinant

    Listed in the ADVERSE REACTIONS section of the FDA label for Liraglutide Recombinant. Read the label on DailyMed ›

  • A skin rash Additional detail

    Coleus

    “Two cases of contact dermatitis have been reported following airborne exposure to coleus.”

    Coleus · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 44426. Dooms-Goossens, A., Borghijs, A., Degreef, H., Devriese, E. G., and Geuns, J. M. Airborne contact dermatitis to Coleus. Contact Dermatitis 1987;17(2):109-110. PubMed
    2. 44418. van Hecke, E., Hindryckx, P., Geuns, J. M., and Devriese, E. Airborne contact dermatitis from coleus in a housewife. Contact Dermatitis 1991;25(2):128-129. PubMed

    Liraglutide Recombinant

    Listed in the ADVERSE REACTIONS section of the FDA label for Liraglutide Recombinant. Read the label on DailyMed ›

Reported for Coleus but not commonly for Liraglutide Recombinant: eye irritation or redness, a fast or pounding heartbeat, low blood pressure and flushing.

Effects for Liraglutide Recombinant come from the ADVERSE REACTIONS section of its FDA label; effects for Coleus come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Coleus in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. Evidence from animal research suggests that high doses of coleus can inhibit embryo implantation and/or delay fetal development; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Liraglutide Recombinant Is Prescribed For, and What Coleus Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Liraglutide Recombinant is a prescription medicine with approved uses on its FDA label. Coleus is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Liraglutide Recombinant is prescribed for: Saxenda is used alongside a reduced-calorie diet and increased physical activity for chronic weight management. It is approved for adults with a BMI of 30 or higher, or a BMI of 27 or higher if they also have at least one weight-related condition such as high blood pressure, type 2 diabetes, or dyslipidemia (abnormal cholesterol or fat levels). It is also approved for adolescents aged 12 and older who weigh more than 60 kg and meet certain BMI thresholds for obesity. Saxenda should not be used together with other liraglutide-containing products or any other GLP-1 receptor agonist.

Read the rest of what Liraglutide Recombinant is prescribed for

Its safety and effectiveness in combination with other prescription or over-the-counter weight-loss products have not been established.

Coleus has been studied for:

  • Obesity studied, not established Coleus has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Coleus for obesity

    It is unclear if oral coleus is beneficial in patients with obesity.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Liraglutide Recombinant on your own; if you are taking Coleus for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Liraglutide Recombinant

This page covers Coleus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Liraglutide Recombinant page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Liraglutide Recombinant page

“If you take liraglutide (Saxenda), handle this page with real care, because all 239 ingredients on it act on the same thing the drug does, your blood sugar. The one major entry, Siberian cocklebur, has caused severe hypoglycemia, dangerously low blood sugar, in people and should never be combined with a glucose-lowering medicine.”

Reviewed by 2 · Jul 18, 2026

Open the Liraglutide Recombinant interaction page

One more smart check

Taking Coleus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 803 real supplement products containing Coleus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coleus. Even though Coleus itself has no known interaction with Liraglutide Recombinant, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coleus and Liraglutide Recombinant Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coleus
Top 25%

#235 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Liraglutide Recombinant
Top 25%

#426 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Coleus reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Coleus and Liraglutide Recombinant records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Coleus

What is Coleus?

Coleus
  • Weight management
  • Asthma and breathing
  • High blood pressure
  • Heart conditions
  • Glaucoma (eye pressure)
  • Exercise and body composition

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. While early lab and small human studies are interesting, solid proof that Coleus supplements help any of these conditions is limited. Talk to your pharmacist or doctor before using it, especially if you have heart problems or low blood pressure.

Coleus forskohlii · Lamiaceae · Roots (source of forskolin) · Capsules, tablets, standardized extracts (often standardized to forskolin), powders

An interaction check asks whether these two react with each other — it does not ask whether Coleus is a good idea for someone in your situation. Here is what our Coleus record says about it on its own.

Coleus: dosing

There is no official, well-established dose for Coleus. Products vary widely in strength and are often standardized to a certain percentage of forskolin, but the best dose for any health goal has not been proven.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Coleus monograph — the full record covers uses, side effects and every documented interaction.

Read the full Coleus monograph & all interactions
Medication

About Liraglutide Injection

What Is Liraglutide Injection Used For?

Brand name: Saxenda

Saxenda is used alongside a reduced-calorie diet and increased physical activity for chronic weight management. It is approved for adults with a BMI of 30 or higher, or a BMI of 27 or higher if they also have at least one weight-related condition such as high blood pressure, type 2 diabetes, or dyslipidemia (abnormal cholesterol or fat levels). It is also approved for adolescents aged 12 and older who weigh more than 60 kg and meet certain BMI thresholds for obesity.

Saxenda should not be used together with other liraglutide-containing products or any other GLP-1 receptor agonist. Its safety and effectiveness in combination with other prescription or over-the-counter weight-loss products have not been established.

See full Liraglutide Injection drug information
Keep checking

Other Drugs & Coleus

Browse every other medication we’ve checked against Coleus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

29Major
886Moderate
0Minor
1,914No known interaction
29 Major 886 Moderate 1,914 No interaction
Major

29 interactions

Moderate

886 interactions

Showing 60 of 886 moderate interactions — see all 886 on the Coleus page.

No interaction 1,914 drugs checked — show the list

We also checked Coleus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,914 medications checked with no known interaction — see the full Coleus list.

See the full Coleus interactions page
See every supplement checked against Liraglutide Recombinant, ranked by severity
Evidence & sources

Coleus References

The 16 references that drive our Coleus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Baumann G, Felix S, Sattelberger U, Klein G. Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestiv cardiomyopathy. A comparative study with dobutamine and sodium nitroprusside. J Cardiovasc Pharmacol 1990;16:93-100.
  2. Kramer W, Thormann J, Kindler M, Schlepper M. Effects of forskolin on left ventricular function in dilated cardiomyopathy. Arzneimittelforschung 1987;37:364-7.
  3. Bauer K, Dietersdorfer F, Kaspar S, et al. Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma. Clin Pharmacol Ther 1993;53:76-83. PubMed
  4. Christenson JT, Thulesius O, Nazzal MM. The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release. Vasa 1995;24:56-61.
  5. Agarwal KC, Zielinski BA, Maitra RS. Significance of plasma adenosine in the antiplatelet activity of forskolin: potentiation by dipyridamole and dilazep. Thromb Haemost 1989;61:106-10. DOI
  6. Agarwal KC, Parks RE. Forskolin: a potential antimetastatic agent. Int J Cancer 1983;32:801-4. PubMed
  7. Almeida, F. C. and Lemonica, I. P. The toxic effects of Coleus barbatus B. on the different periods of pregnancy in rats. J Ethnopharmacol 2000;73(1-2):53-60. PubMed
  8. Ding, X. and Staudinger, J. L. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway. J Pharmacol Exp Ther 2005;312(2):849-856. PubMed
  9. Staudinger, J. L., Ding, X., and Lichti, K. Pregnane X receptor and natural products: beyond drug-drug interactions. Expert.Opin Drug Metab Toxicol 2006;2(6):847-857. PubMed
  10. van Hecke, E., Hindryckx, P., Geuns, J. M., and Devriese, E. Airborne contact dermatitis from coleus in a housewife. Contact Dermatitis 1991;25(2):128-129. PubMed
  11. Schlepper, M., Thormann, J., and Mitrovic, V. Cardiovascular effects of forskolin and phosphodiesterase-III inhibitors. Basic Res Cardiol 1989;84 Suppl 1:197-212. PubMed
  12. Dooms-Goossens, A., Borghijs, A., Degreef, H., Devriese, E. G., and Geuns, J. M. Airborne contact dermatitis to Coleus. Contact Dermatitis 1987;17(2):109-110. PubMed
  13. Lindner, E., Dohadwalla, A. N., and Bhattacharya, B. K. Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohli: Forskolin. Arzneimittelforschung 1978;28(2):284-289.
  14. Loftus HL, Astell KJ, Mathai ML, et al. Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial. Nutrients. 2015;7(11): PubMed
  15. Yokotani K, Chiba T, Sato Y, et al. Hepatic cytochrome P450 mediates interaction between warfarin and Coleus forskohlii extract in vivo and in vitro. J Pharm Pharmacol. 2012;64(12):1793-801.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Coleus and Liraglutide Recombinant Together: Common Questions

Is it safe to take Coleus with Liraglutide Recombinant?
We do not list a known interaction between Coleus and Liraglutide Recombinant. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Coleus and Liraglutide Recombinant have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Coleus and Liraglutide Recombinant used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Coleus in each. That is a conversation for your prescriber, especially if Liraglutide Recombinant is being adjusted to a target.
How was the Coleus and Liraglutide Recombinant combination checked?
Interactions in our licensed database are recorded against drug classes. Liraglutide Recombinant is filed under 1 classification, and Coleus has documented interactions with 7 drug classes — none of Liraglutide Recombinant's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Coleus interact with any other medications?
Yes. Coleus has 915 documented drug interactions in our database — Liraglutide Recombinant is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Liraglutide Recombinant interact with any supplements?
Yes. Liraglutide Recombinant has documented interactions with 239 supplements in our database — Coleus is not one of them. The Liraglutide Recombinant interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Coleus monograph Uses, safety profile, and every drug interaction in one place Liraglutide Injection drug information The full plain-English guide to this medication Liraglutide Recombinant supplement interactions Every supplement checked against Liraglutide Recombinant, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 16 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Liraglutide Recombinant and Coleus?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.