Drug & supplement interaction

Copaiba Balsam + Cefaclor

Cefaclor brand names: Ceclor CD, Ceclor.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Copaiba Balsam and Cefaclor in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Cefaclor states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Copaiba Balsam and Cefaclor

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cefaclor and Copaiba Balsam in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Copaiba Balsam at all — not against Cefaclor, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Copaiba Balsam safety at a glance

Copaiba Balsam overall Use caution Generally tolerated in small amounts but human safety data are limited, especially for concentrated oral oil.
Pregnancy Possibly Unsafe When used orally in medicinal amounts; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally in medicinal amounts; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cefaclor and Copaiba Balsam? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Copaiba Balsam and Cefaclor May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Hives Worth acting on Additional detail

    Copaiba Balsam

    “When applied topically, copaiba balsam can cause contact dermatitis with erythema, a papular or vesicular rash, urticaria, and petechiae. The rash may leave brown spots after healing (18).”

    Copaiba Balsam · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Chills / Trouble sleeping Additional detail

    Copaiba Balsam

    “Orally, copaiba balsam in repeated doses of 5 grams or more has been reported to cause shivering, tremor, and insomnia (18).”

    Copaiba Balsam · Natural Medicines adverse-effect record, reported in insomnia.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Tremor or shakiness Additional detail

    Copaiba Balsam

    “Orally, copaiba balsam is well tolerated when used as a food additive. In doses of 5 grams or greater, copaiba balsam can cause serious adverse effects.

    Most Common Adverse Effects:

    Topically: Contact dermatitis.

    Serious Adverse Effects (Rare):

    Orally: Doses of 5 grams or more have been reported to cause diarrhea, shivers, stomach pain, tremor, and vomiting.”

    Copaiba Balsam · Natural Medicines adverse-effect record, reported in dermatitis.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Stomach pain / Diarrhea / Vomiting Additional detail

    Copaiba Balsam

    “Orally, copaiba balsam in single doses of 5 grams or more has been reported to cause stomach pain, vomiting, and diarrhea (11,18).”

    Copaiba Balsam · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • A skin rash Additional detail

    Copaiba Balsam

    Recorded for Copaiba Balsam in the same Natural Medicines adverse-effect record shown under Tremor or shakiness above.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

Reported for Copaiba Balsam but not commonly for Cefaclor: bleeding or bruising.

Effects for Cefaclor come from the ADVERSE REACTIONS section of its FDA label; effects for Copaiba Balsam come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Copaiba Balsam in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally in medicinal amounts; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Cefaclor Products Have a Food Rule — Copaiba Balsam Should Not Break It

At least one FDA label for a product containing Cefaclor says to take it with food. If you take Copaiba Balsam on an empty stomach out of habit, keep them separate — and take Cefaclor with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Cefaclor products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION The absorption of cefaclor extended-release tablets is enhanced when it is administered with food.

From the Dosage and Administration section of the FDA label we read for Cefaclor — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Cefaclor

This page covers Copaiba Balsam only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cefaclor page lists 60 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), African Wild Potato (moderate) and Aristolochia (moderate).

By severity: 3 major · 46 moderate · 11 minor.

From our pharmacist’s overview on the Cefaclor page

“The entries worth understanding before any others on this cefaclor (Ceclor) page are the kidney risks and charcoal. Cefaclor is a cephalosporin antibiotic, typically a short course for ear, sinus, throat, or skin infections, and two herbs here, Siberian cocklebur and asarabacca, can damage the kidneys on their own, so pairing either wi…”

Reviewed by 2 · Jul 18, 2026

Open the Cefaclor interaction page

One more smart check

Taking Copaiba Balsam as Part of a Dietary Supplement Product? Check It for Interactions

We hold 9 real supplement products containing Copaiba Balsam, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Copaiba Balsam. Even though Copaiba Balsam itself has no known interaction with Cefaclor, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Copaiba Balsam and Cefaclor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Copaiba Balsam
Steady interest

#1,080 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cefaclor
Top 10%

#241 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Copaiba Balsam reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Copaiba Balsam and Cefaclor records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Copaiba Balsam

What is Copaiba Balsam?

  • Inflammation and joint pain
  • Skin wounds and irritation
  • Antimicrobial and antifungal support
  • Sore throat and respiratory comfort
  • Digestive complaints

Copaiba balsam is a resin from South American Copaifera trees, valued in traditional medicine and now popular as an essential oil and supplement, mainly for inflammation and skin concerns. Human evidence is limited, so its benefits are not well proven. Talk to a pharmacist or doctor before using it, and avoid undiluted oral use of the essential oil.

Copaifera officinalis · Fabaceae · Oleoresin (balsam) tapped from the trunk; essential oil distilled from the resin · Essential oil, oral softgels/capsules, topical creams and ointments, tinctures

An interaction check asks whether these two react with each other — it does not ask whether Copaiba Balsam is a good idea for someone in your situation. Here is what our Copaiba Balsam record says about it on its own.

Copaiba Balsam: dosing

There is no well-established, standardized dose for copaiba balsam. The amount in products varies widely depending on whether it is a topical cream, an oral softgel, or a pure essential oil.The safest approach is to follow the directions on the product label and not exceed them. For topical use, dilute the essential oil in a carrier oil and patch test first. Avoid taking concentrated essential oil by mouth unless a knowledgeable healthcare professional directs you to.

From our Copaiba Balsam monograph — the full record covers uses, side effects and every documented interaction.

Read the full Copaiba Balsam monograph & all interactions
Medication

About Cefaclor

What Is Cefaclor Used For?

Brand names: Ceclor CD, Ceclor

Cefaclor treats a range of bacterial infections. The capsule and oral suspension forms are used for ear infections (otitis media), lower respiratory tract infections including pneumonia, strep throat and tonsillitis, urinary tract infections (including kidney infections and bladder infections), and skin and skin structure infections.

The extended-release tablet form of Cefaclor is approved for a narrower set of uses: acute bacterial flare-ups of chronic bronchitis, strep throat and tonsillitis, and uncomplicated skin infections. Not all infections approved for the capsule or suspension are approved for the extended-release tablet — your prescriber will choose the right form for your infection.

Most-Reported Side Effects for Cefaclor

From FAERS, the FDA’s public side-effect reporting system (1,535 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug hypersensitivity 252 reports
Nausea 159 reports
Vomiting 159 reports
Fatigue 137 reports
Fever 121 reports
See full Cefaclor drug information
Keep checking

Other Drugs & Copaiba Balsam

Browse every other medication we’ve checked against Copaiba Balsam — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Copaiba Balsam References

The 2 references that drive our Copaiba Balsam monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Copaiba Balsam and Cefaclor Together: Common Questions

Is it safe to take Copaiba Balsam with Cefaclor?
We do not list a known interaction between Copaiba Balsam and Cefaclor. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Copaiba Balsam and Cefaclor have any of the same side effects?
Yes — our sources link each of them separately to 8 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Copaiba Balsam and Cefaclor at the same time of day?
At least one FDA label for a product containing Cefaclor says to take it with food. If you take Copaiba Balsam on an empty stomach out of habit, keep them separate and take Cefaclor with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Cefaclor products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Cefaclor interact with any supplements?
Yes. Cefaclor has documented interactions with 60 supplements in our database — Copaiba Balsam is not one of them. The Cefaclor interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Cefaclor and Copaiba Balsam?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.