Cramp Bark + Glutethimide
Glutethimide brand name: Doriden.
We found no known interaction between Cramp Bark and Glutethimide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Cramp Bark and Glutethimide
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Glutethimide and Cramp Bark in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Cramp Bark at all — not against Glutethimide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Cramp Bark safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Glutethimide
This page covers Cramp Bark only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glutethimide page lists 134 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Henbane (major).
By severity: 9 major · 108 moderate · 17 minor.
From our pharmacist’s overview on the Glutethimide page
“Picture the person prescribed glutethimide (Doriden), an old sedative sleeping pill, adding kava or a glass of wine to get through a restless night. That is exactly the pairing this list warns hardest against.”
Reviewed by 2 · Jul 18, 2026
Taking Cramp Bark as Part of a Dietary Supplement Product? Check It for Interactions
We hold 256 real supplement products containing Cramp Bark, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cramp Bark. Even though Cramp Bark itself has no known interaction with Glutethimide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Cramp Bark and Glutethimide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#504 of 1,452 supplements looked up here in the last 7 days
#1,207 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
- Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Cramp Bark and Glutethimide records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Cramp Bark
What is Cramp Bark?
- Menstrual cramps
- Muscle spasms
- General cramping pain
- Stomach or digestive cramps
- Easing tension
Cramp Bark is the dried bark of Viburnum opulus, traditionally used to ease muscle and menstrual cramps. Modern, high-quality human studies are very limited, so its effectiveness is not well proven. If you want to try it, talk with your pharmacist or doctor first, and avoid it during pregnancy because safety is unclear.
Viburnum opulus · Adoxaceae · Dried bark · Tea (decoction), tincture, liquid extract, capsules
An interaction check asks whether these two react with each other — it does not ask whether Cramp Bark is a good idea for someone in your situation. Here is what our Cramp Bark record says about it on its own.
Cramp Bark: dosing
There is no well-established or standardized dose for Cramp Bark. Products vary widely in strength, especially between teas, tinctures, and capsules.The safest approach is to follow the directions on the product label and not exceed them. Because quality and concentration differ between brands, and because little is known about safe long-term use, it is a good idea to review the product with your pharmacist before starting.
From our Cramp Bark monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Cramp Bark
Browse every other medication we’ve checked against Cramp Bark — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Cramp Bark against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Losartan Potassium ›
- Sertraline ›
- Rosuvastatin ›
- Acetaminophen ›
- Aspirin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Levothyroxine, Liothyronine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Amlodipine Besylate ›
- Docusate ›
- Metformin ›
- Prednisone ›
- Methamphetamine ›
- Amitriptyline ›
- Tadalafil ›
- Lisdexamfetamine ›
- Semaglutide ›
- Amphetamine ›
- Hydroxyurea ›
- Valacyclovir ›
- Propranolol ›
- Sumatriptan ›
- Lisinopril ›
- Amoxicillin ›
- Methotrexate ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Doxycycline ›
- Acetaminophen, Aspirin, Caffeine ›
- Pregabalin ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Naproxen ›
- Bendamustine ›
- Quetiapine ›
- Clonazepam ›
- Acyclovir ›
- Buspirone ›
- Duloxetine ›
- Omeprazole ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Cramp Bark list.
Sources & How We Checked
We checked Cramp Bark against Glutethimide in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking Cramp Bark and Glutethimide Together: Common Questions
Is it safe to take Cramp Bark with Glutethimide?
Does Glutethimide interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Glutethimide and Cramp Bark?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.