Drug & supplement interaction

Dyer's Broom + Pentoxifylline

Pentoxifylline brand name: Trental.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Dyer's Broom and Pentoxifylline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Pentoxifylline states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Dyer's Broom and Pentoxifylline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pentoxifylline and Dyer's Broom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Dyer's Broom safety at a glance

Dyer's Broom overall Use caution It contains potentially toxic alkaloids and has little safety data, so caution is advised.
Pregnancy Possibly Unsafe When used orally. Dyer's broom may have uterine stimulant activity. Read the full pregnancy detail
Breastfeeding Avoid Avoid while breastfeeding due to a lack of safety information.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pentoxifylline and Dyer's Broom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pentoxifylline

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pentoxifylline is filed under 2 classifications — anticoagulant/antiplatelet drugs, oral drugs. Dyer's Broom has documented interactions with 1 drug class — the most serious being caffeine (moderate) — and none of Pentoxifylline’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Dyer's Broom Does Interact With Other Medications

Dyer's Broom has 29 moderate known drug interactions in our database — Pentoxifylline isn’t one of them. If you take anything else, check it against the full list below.

Moderate 29 No known interaction 2,801 (incl. Pentoxifylline)
Taking anything else?

Check Another of Your Medications Against Dyer's Broom

Covers the 2,830 medications we’ve checked against Dyer's Broom. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Dyer's Broom and Pentoxifylline May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea / Nausea / Vomiting reported in 10.1% of FDA reports for Pentoxifylline Additional detail

    Dyer's Broom

    “Orally, dyer's broom may cause nausea and vomiting (12). Overuse of dyer's broom can lead to diarrhea (12,18).”

    Dyer's Broom · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Pentoxifylline

    Listed in the ADVERSE REACTIONS section of the FDA label for Pentoxifylline, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Pentoxifylline come from the ADVERSE REACTIONS section of its FDA label; effects for Dyer's Broom come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 4,245 voluntary FDA FAERS reports for Pentoxifylline that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Dyer's Broom in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. Dyer's broom may have uterine stimulant activity.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Pentoxifylline Products Have a Food Rule — Dyer's Broom Should Not Break It

At least one FDA label for a product containing Pentoxifylline says to take it with food. If you take Dyer's Broom on an empty stomach out of habit, keep them separate — and take Pentoxifylline with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Pentoxifylline products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION The usual dosage of pentoxifylline in extended-release tablet form is one tablet (400 mg) three times a day with meals.

From the Dosage and Administration section of the FDA label we read for Pentoxifylline — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Pentoxifylline

This page covers Dyer's Broom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pentoxifylline page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Piracetam (major), Aconite (moderate) and Allspice (moderate).

By severity: 3 major · 190 moderate · 25 minor.

From our pharmacist’s overview on the Pentoxifylline page

“Pentoxifylline (Trental) improves blood flow in people with poor leg circulation partly by making platelets less sticky, so treat this list as one to read carefully rather than skim. Of the 218 supplements on file, 202 can also slow clotting, which means adding them stacks bleeding risk on bleeding risk.”

Reviewed by 2 · Jul 18, 2026

Open the Pentoxifylline interaction page

One more smart check

Taking Dyer's Broom as Part of a Dietary Supplement Product? Check It for Interactions

We hold 8 real supplement products containing Dyer's Broom, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dyer's Broom. Even though Dyer's Broom itself has no known interaction with Pentoxifylline, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dyer's Broom and Pentoxifylline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dyer's Broom
Steady interest

#990 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pentoxifylline
Top half

#1,342 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dyer's Broom reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Dyer's Broom and Pentoxifylline records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Dyer's Broom

What is Dyer's Broom?

Dyer's Broom
  • Skin irritation
  • Respiratory complaints
  • Gout
  • Lower back and pelvic pain
  • Digestive upset
  • As a natural yellow dye

Dyer's broom is a European flowering plant best known historically as a source of yellow textile dye, with some traditional medicinal uses. There is very little reliable human research to support any health benefit, and it contains compounds that can be toxic in larger amounts, so it should be used cautiously, if at all. Talk to your pharmacist or doctor before trying it.

Genista tinctoria · Fabaceae · Flowering tops, stems, and sometimes roots · Tea, dried herb, tincture, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Dyer's Broom is a good idea for someone in your situation. Here is what our Dyer's Broom record says about it on its own.

Dyer's Broom: dosing

There is no established standard dose for dyer's broom, and no reliable human research to guide safe amounts. The concentration of active compounds can vary widely between products and plant batches.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Dyer's Broom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Dyer's Broom monograph & all interactions
Medication

About Pentoxifylline

What Is Pentoxifylline Used For?

Brand name: Trental

Pentoxifylline Extended-Release Tablets are used to treat intermittent claudication — leg pain, cramping, or fatigue that happens during walking because narrowed arteries aren't delivering enough blood to the muscles. The underlying cause is chronic occlusive arterial disease, a condition where the arteries in the limbs become blocked or narrowed over time.

Pentoxifylline can help improve walking distance and reduce symptoms, but it is not a substitute for procedures that physically open or bypass blocked arteries when those treatments are needed.

Most-Reported Side Effects for Pentoxifylline

From FAERS, the FDA’s public side-effect reporting system (4,300 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 457 reports
Diarrhea 431 reports
Dyspnea 405 reports
Fall 376 reports
Dizziness 371 reports
See full Pentoxifylline drug information
Keep checking

Other Drugs & Dyer's Broom

Browse every other medication we’ve checked against Dyer's Broom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
29Moderate
0Minor
2,800No known interaction
29 Moderate 2,800 No interaction
Moderate

29 interactions

No interaction 2,800 drugs checked — show the list

We also checked Dyer's Broom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,800 medications checked with no known interaction — see the full Dyer's Broom list.

See the full Dyer's Broom interactions page
See every supplement checked against Pentoxifylline, ranked by severity
Evidence & sources

Dyer's Broom References

The 3 references that drive our Dyer's Broom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Dyer's Broom and Pentoxifylline Together: Common Questions

Is it safe to take Dyer's Broom with Pentoxifylline?
We do not list a known interaction between Dyer's Broom and Pentoxifylline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Dyer's Broom and Pentoxifylline have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Dyer's Broom and Pentoxifylline at the same time of day?
At least one FDA label for a product containing Pentoxifylline says to take it with food. If you take Dyer's Broom on an empty stomach out of habit, keep them separate and take Pentoxifylline with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Pentoxifylline products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Dyer's Broom and Pentoxifylline combination checked?
Interactions in our licensed database are recorded against drug classes. Pentoxifylline is filed under 2 classifications, and Dyer's Broom has documented interactions with 1 drug class — none of Pentoxifylline's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Dyer's Broom interact with any other medications?
Yes. Dyer's Broom has 29 documented drug interactions in our database — Pentoxifylline is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pentoxifylline interact with any supplements?
Yes. Pentoxifylline has documented interactions with 218 supplements in our database — Dyer's Broom is not one of them. The Pentoxifylline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Dyer's Broom monograph Uses, safety profile, and every drug interaction in one place Pentoxifylline drug information The full plain-English guide to this medication Pentoxifylline supplement interactions Every supplement checked against Pentoxifylline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pentoxifylline and Dyer's Broom?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.