Fasting + Duloxetine
Duloxetine brand names: Cymbalta, Drizalma Sprinkle, Irenka.
We found no known interaction between Fasting and Duloxetine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Fasting and Duloxetine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Duloxetine and Fasting in our sources. This does not guarantee that the combination is completely free of risk — research on Fasting alongside specific medications may be limited.
Fasting is an eating pattern rather than something you take. Ask your pharmacist or doctor before changing how you eat while on a prescribed medicine: some medicines are dosed around meals, and a change in diet can change how they work. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Fasting safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Duloxetine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Duloxetine is filed under 8 classifications — including antidepressant drugs, cytochrome p450 2d6 (cyp2d6) inhibitors, serotonergic drugs. Fasting has documented interactions with 4 drug classes — the most serious being warfarin (coumadin) (major), anticoagulant/antiplatelet drugs (moderate) and antidiabetes drugs (moderate) — and none of Duloxetine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Fasting Does Interact With Other Medications
Fasting has 2 major, 206 moderate known drug interactions in our database — Duloxetine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Fasting
We haven’t checked that one against Fasting yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Fasting. Pick one to open its full report.
What Duloxetine Is Prescribed For, and What Fasting Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Duloxetine is a prescription medicine with approved uses on its FDA label. Fasting is an eating pattern: what follows is what researchers have looked at it for, and how strong that evidence is.
Duloxetine is prescribed for: Duloxetine delayed-release capsules treat major depressive disorder (MDD) and generalized anxiety disorder (GAD) in adults. They also manage diabetic peripheral neuropathic pain (nerve pain from diabetes), fibromyalgia, and chronic musculoskeletal pain (such as chronic low back pain and pain from osteoarthritis) in adults. GAD is also approved in pediatric patients 7 years and older for Cymbalta, Drizalma Sprinkle, and certain duloxetine delayed-release capsule products. Fibromyalgia is approved in patients 13 years and older for Cymbalta and some duloxetine delayed-release capsule products.
Read the rest of what Duloxetine is prescribed for
Age-specific approvals vary by product — follow your prescriber's guidance on which product is right for your age group.
Fasting has been studied for:
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Fibromyalgia studied, not established Fasting has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Fasting for fibromyalgia
Although there is interest in using fasting for fibromyalgia, there is insufficient reliable information about the clinical effects of fasting for this condition.
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Diabetes studied, not established Fasting has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Fasting for diabetes
It is unclear if fasting is beneficial for diabetes.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Duloxetine on your own; if you are taking Fasting for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Fasting or Duloxetine
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Fasting or Duloxetine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Is It Safe To Take Ignatia Amara (Ignatius Bean) With Cymbalta? ›
- Does Cymbalta (Duloxetine) Interact With Berberine? ›
- Does Apple Cider Vinegar Interact With Cymbalta? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Duloxetine
This page covers Fasting only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Duloxetine page lists 132 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Lithium (major), Siberian Cocklebur (major) and Wine (major).
By severity: 5 major · 107 moderate · 20 minor.
Where Fasting and Duloxetine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#685 of 1,452 supplements looked up here in the last 7 days
#47 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fasting reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Fasting and Duloxetine records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Fasting
What is Fasting?
- Weight loss
- Blood sugar control
- Heart health
- Religious or spiritual practice
- General wellness and longevity
Fasting means voluntarily going without food (and sometimes drink) for set periods. Some research suggests it may help with weight loss and blood sugar in certain people, but results vary and quality of evidence is mixed. It is not safe for everyone, so check with your doctor or pharmacist before starting—especially if you take medication or have a health condition.
Not applicable (a dietary practice, not a substance) · Time-restricted eating, alternate-day fasting, periodic multi-day fasts, intermittent fasting (e.g., 16:8 or 5:2), religious fasting
An interaction check asks whether these two react with each other — it does not ask whether Fasting is a good idea for someone in your situation. Here is what our Fasting record says about it on its own.
Fasting: dosing
There is no single "correct" fasting schedule, and no standardized dose. Popular approaches include daily time-restricted eating (such as a 16:8 pattern), the 5:2 plan, and alternate-day fasting. The best choice depends on your health, lifestyle, and goals.If you are new to fasting, it's wise to start gently—such as a slightly shorter eating window—and to drink plenty of water during fasting periods (unless your fast restricts fluids for religious reasons).
From our Fasting monograph — the full record covers uses, side effects and every documented interaction.
About Duloxetine
What Is Duloxetine Used For?
Brand names: Cymbalta, Drizalma Sprinkle, Irenka
Duloxetine delayed-release capsules treat major depressive disorder (MDD) and generalized anxiety disorder (GAD) in adults. They also manage diabetic peripheral neuropathic pain (nerve pain from diabetes), fibromyalgia, and chronic musculoskeletal pain (such as chronic low back pain and pain from osteoarthritis) in adults.
GAD is also approved in pediatric patients 7 years and older for Cymbalta, Drizalma Sprinkle, and certain duloxetine delayed-release capsule products. Fibromyalgia is approved in patients 13 years and older for Cymbalta and some duloxetine delayed-release capsule products. Age-specific approvals vary by product — follow your prescriber's guidance on which product is right for your age group.
Other Drugs & Fasting
Browse every other medication we’ve checked against Fasting — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
2 interactions
206 interactions
- Diclofenac Sodium ›
- Ibuprofen ›
- Aspirin ›
- Insulin (rdna) ›
- Naproxen ›
- Minocycline ›
- Glyburide ›
- Insulin (pork) ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Insulin (human) ›
- Ketoprofen ›
- Acarbose ›
- Bivalirudin ›
- Insulin Glargine ›
- Semaglutide ›
- Bromfenac Sodium ›
- Chlorpropamide ›
- Dabigatran ›
- Diclofenac Epolamine ›
- Exenatide ›
- Glipizide ›
- Glucagon ›
- Iloprost ›
- Insulin Lispro ›
- Metformin ›
- Piroxicam ›
- Repaglinide ›
- Sitagliptin ›
- Streptokinase ›
- Ticlopidine ›
- Tirzepatide ›
- Treprostinil (oral) ›
- Abciximab ›
- Abrocitinib ›
- Acenocoumarol ›
- Acetohexamide ›
- Acetylsalicylic Acid ›
- Albiglutide ›
- Alogliptin ›
- Anacaulase-bcdb ›
- Anagrelide ›
- Anisindione ›
- Antithrombin Iii ›
- Apixaban ›
- Argatroban ›
- Betrixaban ›
- Cablivi ›
- Canagliflozin ›
- Cangrelor ›
- Cilostazol ›
- Clopidogrel ›
- Dalteparin ›
- Danaparoid ›
- Dapagliflozin ›
- Dasiglucagon Hydrochloride ›
- Defibrotide Sodium ›
- Diclofenac ›
- Dicumarol ›
- Dulaglutide ›
Showing 60 of 206 moderate interactions — see all 206 on the Fasting page.
No interaction 2,621 drugs checked — show the list
We also checked Fasting against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Ivermectin ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Dapsone ›
- Diazepam ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Mannitol ›
- Cephalexin ›
- Roxithromycin ›
- Pegunigalsidase Alfa-iwxj ›
- Atorvastatin Calcium ›
Showing the 60 most looked-up of 2,621 medications checked with no known interaction — see the full Fasting list.
Fasting References
The 23 references that drive our Fasting monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Carter S, Clifton PM, Keogh JB. Effect of intermittent compared with continuous energy restricted diet on glycemic control in patients with Type 2 diabetes: A randomized noninferiority trial. JAMA Netw Open. 2018;1(3):e180756. PubMed
- Tinsley GM, Moore ML, Graybeal AJ, et al. Time-restricted feeding plus resistance training in active females: a randomized trial. Am J Clin Nutr. 2019;110(3):628-640. PubMed
- Cioffi I, Evangelista A, Ponzo V, et al. Intermittent versus continuous energy restriction on weight loss and cardiometabolic outcomes: a systematic review and meta-analysis of randomized controlled trials. J Transl Med. 2018;16(1):371. PubMed
- Schübel R, Nattenmüller J, Sookthai D, et al. Effects of intermittent and continuous calorie restriction on body weight and metabolism over 50 wk: a randomized controlled trial. Am J Clin Nutr. 2018;108(5):933-945. PubMed
- Sundfør TM, Svendsen M, Tonstad S. Effect of intermittent versus continuous energy restriction on weight loss, maintenance and cardiometabolic risk: A randomized 1-year trial. Nutr Metab Cardiovasc Dis. 2018;28(7):698-706. PubMed
- Harris L, Hamilton S, Azevedo LB, et al. Intermittent fasting interventions for treatment of overweight and obesity in adults: a systematic review and meta-analysis. JBI Database System Rev Implement Rep. 2018;16(2):507-547. PubMed
- Harris L, McGarty A, Hutchison L, Ells L, Hankey C. Short-term intermittent energy restriction interventions for weight management: a systematic review and meta-analysis. Obes Rev. 2018;19(1):1-13. PubMed
- Conley M, Le Fevre L, Haywood C, Proietto J. Is two days of intermittent energy restriction per week a feasible weight loss approach in obese males? A randomised pilot study. Nutr Diet. 2018;75(1):65-72. PubMed
- Chowdhury A, Khan H, Lasker SS, Chowdhury TA. Fasting outcomes in people with diabetes and chronic kidney disease in East London during Ramadan 2018: The East London diabetes in Ramadan survey. Diabetes Res Clin Pract. 2019;152:166-170. PubMed
- Wilhelmi de Toledo F, Grundler F, Bergouignan A, Drinda S, Michalsen A. Safety, health improvement and well-being during a 4 to 21-day fasting period in an observational study including 1422 subjects. PLoS One. 2019;14(1):e0209353. PubMed
- Finnell JS, Saul BC, Goldhamer AC, Myers TR. Is fasting safe? A chart review of adverse events during medically supervised, water-only fasting. BMC Complement Altern Med. 2018;18(1):67. PubMed
- Katada Y, Nakagawa S, Nishimura A, et al. Effects of fasting on warfarin sensitivity index in patients undergoing cardiovascular surgery. Eur J Clin Pharmacol. 2019;75(4):561-568. PubMed
- Lai YF, Cheen MHH, Lim SH, et al. The effects of fasting in Muslim patients taking warfarin. J Thromb Haemost. 2014;12(3):349-54. PubMed
- Grajower MM, Horne BD. Clinical management of intermittent fasting in patients with diabetes mellitus. Nutrients. 2019;11(4):873. PubMed
- Ibrahim M, Davies MJ, Ahmad E, et al. Recommendations for management of diabetes during Ramadan: update 2020, applying the principles of the ADA/EASD consensus. BMJ Open Diabetes Res Care. 2020;8(1):e001248. PubMed
- Jamshed H, Steger FL, Bryan DR, et al. Effectiveness of early time-restricted eating for weight loss, fat loss, and cardiometabolic health in adults with obesity: A randomized clinical trial. JAMA Intern Med. 2022;182(9):953-962. PubMed
- Li C, Xing C, Zhang J, Zhao H, Shi W, He B. Eight-hour time-restricted feeding improves endocrine and metabolic profiles in women with anovulatory polycystic ovary syndrome. J Transl Med 2021;19(1):148. PubMed
- Wang X, Li Q, Liu Y, Jiang H, Chen W. Intermittent fasting versus continuous energy-restricted diet for patients with type 2 diabetes mellitus and metabolic syndrome for glycemic control: A systematic review and meta-analysis of randomized controlled tria
- Peos JJ, Helms ER, Fournier PA, et al. Continuous versus intermittent dieting for fat loss and fat-free mass retention in resistance-trained adults: The ICECAP trial. Med Sci Sports Exerc 2021;53(8):1685-1698. PubMed
- Teong XT, Hutchison AT, Liu B, et al. Eight weeks of intermittent fasting versus calorie restriction does not alter eating behaviors, mood, sleep quality, quality of life and cognitive performance in women with overweight. Nutr Res 2021;92:32-39. PubMed
- He S, Wang J, Zhang J, Xu J. Intermittent versus continuous energy restriction for weight loss and metabolic improvement: A meta-analysis and systematic review. Obesity (Silver Spring) 2021;29(1):108-115. PubMed
- Almutairi N, Shaaban D. Clinical implications of intermittent Ramadan fasting on stable plaque psoriasis: a prospective observational study. Postepy Dermatol Alergol. 2022;39(2):368-374. PubMed
- Lao BN, Luo JH, Xu XY, et al. Time-restricted feeding's effect on overweight and obese patients with chronic kidney disease stages 3-4: A prospective non-randomized control pilot study. Front Endocrinol (Lausanne) 2023;14:1096093. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Duloxetine Is Linked to Lower Levels of One Nutrient
Natural Medicines records Duloxetine as a medicine that can lower these. This is not an interaction with Fasting — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Duloxetine nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Following Fasting While Taking Duloxetine: Common Questions
Is it safe to follow Fasting while taking Duloxetine?
Do Fasting and Duloxetine have any of the same side effects?
Are Fasting and Duloxetine used for the same thing?
How was the Fasting and Duloxetine combination checked?
Does Fasting interact with any other medications?
Does Duloxetine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.