Drug & supplement interaction

Frankincense + Metformin, Linagliptin

Metformin, Linagliptin brand name: Jentadueto.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Frankincense and Metformin, Linagliptin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Metformin, Linagliptin states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Frankincense and Metformin, Linagliptin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Metformin, Linagliptin and Frankincense in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Frankincense at all — not against Metformin, Linagliptin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Frankincense safety at a glance

Frankincense overall Use caution Generally well tolerated short-term, but quality and dosing vary widely between products.
Pregnancy Avoid Not enough safety information; avoid use during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Metformin, Linagliptin and Frankincense? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Frankincense and Metformin, Linagliptin May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Itching Additional detail

    Frankincense

    “Topically and by inhalation, frankincense essential oil seems to be well tolerated. For information on the safety of frankincense when used orally, see the Boswellia serrata monograph.

    Most Common Adverse Effects:

    Topically: Dermatitis, irritation, itching.”

    Frankincense · Natural Medicines adverse-effect record, reported in dermatitis.

    Metformin, Linagliptin

    Listed in the ADVERSE REACTIONS section of the FDA label for Metformin, Linagliptin. Read the label on DailyMed ›

Reported for Frankincense but not commonly for Metformin, Linagliptin: a skin rash.

Effects for Metformin, Linagliptin come from the ADVERSE REACTIONS section of its FDA label; effects for Frankincense come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Metformin, Linagliptin Products Have a Food Rule — Frankincense Should Not Break It

At least one FDA label for a product containing Metformin, Linagliptin says to take it with food. If you take Frankincense on an empty stomach out of habit, keep them separate — and take Metformin, Linagliptin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Metformin, Linagliptin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Individualize the starting dosage of JENTADUETO XR based on the patient's current regimen ( 2.1 ) The maximum recommended dosage is 5 mg linagliptin/2,000 mg metformin HCl once daily ( 2.1 ) Take orally once daily with a meal, with gradual dose escalation to reduce the gastrointestinal effects due to metformin ( 2.1 ) Swallow whole; do not split, crush, dissolve, or che

From the Dosage and Administration section of the FDA label we read for Metformin, Linagliptin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Metformin, Linagliptin

This page covers Frankincense only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metformin, Linagliptin page lists 285 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), St. John's Wort (major), Acai (moderate) and Adrafinil (moderate).

By severity: 3 major · 242 moderate · 40 minor.

From our pharmacist’s overview on the Metformin, Linagliptin page

“Siberian cocklebur is the risk anyone taking metformin and linagliptin (Jentadueto) should understand first, since it has caused severe hypoglycemia in people who consumed it. The wider picture deserves real care too.”

Reviewed by 2 · Jul 18, 2026

Open the Metformin, Linagliptin interaction page

One more smart check

Taking Frankincense as Part of a Dietary Supplement Product? Check It for Interactions

We hold 56 real supplement products containing Frankincense, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Frankincense. Even though Frankincense itself has no known interaction with Metformin, Linagliptin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Frankincense and Metformin, Linagliptin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Frankincense
Top half

#380 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Metformin, Linagliptin
Steady interest

#1,615 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Frankincense reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Frankincense and Metformin, Linagliptin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Frankincense

What is Frankincense?

Frankincense
  • Joint pain and osteoarthritis
  • Inflammation
  • Digestive complaints
  • Asthma and breathing problems
  • Calming aromatherapy

Frankincense is the aromatic resin of the Boswellia tree and is best known for its boswellic acids, which may help with inflammation and joint pain. Early research is promising for conditions like osteoarthritis, but the evidence is still limited and dosing is not standardized. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Boswellia serrata · Burseraceae · Oleo-gum-resin from the tree bark; essential oil distilled from the resin · Capsules and tablets (often standardized Boswellia extract), resin, essential oil for aromatherapy, topical creams

An interaction check asks whether these two react with each other — it does not ask whether Frankincense is a good idea for someone in your situation. Here is what our Frankincense record says about it on its own.

Frankincense: dosing

There is no official, standardized dose of frankincense. Studies have used different Boswellia extracts standardized to varying amounts of boswellic acids, so it is hard to compare products directly.The safest approach is to follow the directions on the product label and choose a reputable brand that lists its boswellic acid content. Essential oils are for inhalation or diluted topical use only and should never be taken by mouth.

From our Frankincense monograph — the full record covers uses, side effects and every documented interaction.

Read the full Frankincense monograph & all interactions
Keep checking

Other Drugs & Frankincense

Browse every other medication we’ve checked against Frankincense — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Frankincense against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Frankincense list.

See the full Frankincense interactions page
See every supplement checked against Metformin, Linagliptin, ranked by severity
Evidence & sources

Frankincense References

The 2 references that drive our Frankincense monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Acebo, E., Raton, J. A., Sautua, S., Eizaguirre, X., Trebol, I., and Perez, J. L. Allergic contact dermatitis from Boswellia serrata extract in a naturopathic cream. Contact Dermatitis 2004;51(2):91-92.
  2. Buonomo M, Hylwa S. Allergic contact dermatitis from Boswellia carterii (frankincense) oil. Contact Dermatitis 2021;85(4):465-467.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Frankincense and Metformin, Linagliptin Together: Common Questions

Is it safe to take Frankincense with Metformin, Linagliptin?
We do not list a known interaction between Frankincense and Metformin, Linagliptin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Frankincense and Metformin, Linagliptin have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Frankincense and Metformin, Linagliptin at the same time of day?
At least one FDA label for a product containing Metformin, Linagliptin says to take it with food. If you take Frankincense on an empty stomach out of habit, keep them separate and take Metformin, Linagliptin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Metformin, Linagliptin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Metformin, Linagliptin interact with any supplements?
Yes. Metformin, Linagliptin has documented interactions with 285 supplements in our database — Frankincense is not one of them. The Metformin, Linagliptin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Frankincense monograph Uses, safety profile, and every drug interaction in one place Metformin, Linagliptin supplement interactions Every supplement checked against Metformin, Linagliptin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Metformin, Linagliptin and Frankincense?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.