Medication interaction hub

What Supplements Interact with Metformin, Linagliptin?

Metformin, Linagliptin brand name: Jentadueto. Every interaction below applies to the brands too.

285 Interactions 3 Major 242 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Metformin, Linagliptin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Metformin, Linagliptin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Siberian cocklebur is the risk anyone taking metformin and linagliptin (Jentadueto) should understand first, since it has caused severe hypoglycemia in people who consumed it. The wider picture deserves real care too. Jentadueto lowers blood sugar on two fronts, and 239 of the 285 supplements and herbs on this page can push that effect further, meaning most of this list is about the danger of dropping too low.

Only 3 entries rate major, and the other two leave you with less medicine rather than more. Activated charcoal soaks up drugs in the gut, and St. John's wort switches on a transport protein that clears linagliptin faster. Fiber supplements can slow absorption as well, so keep them well apart from your dose. The remaining 242 moderate and 40 minor entries mostly add modest glucose-lowering effects of their own, which makes extra blood sugar checks worthwhile whenever you start a new herb.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 242 Minor 40 No known interaction 1,167

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Metformin, Linagliptin: Top Interactions at a Glance

The Metformin, Linagliptin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 285 interacting ingredients — plus 1,167 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Metformin, Linagliptin Combinations Today

The Metformin, Linagliptin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Ginger + Metformin, Linagliptini

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.

Read the full interaction Moderate Likelihood Possible Sweet Orange + Metformin, Linagliptini

Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.

Read the full interaction Moderate Likelihood Possible Milk Thistle + Metformin, Linagliptini

Taking milk thistle with antidiabetes drugs may increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Oats + Metformin, Linagliptini

Theoretically, oats may have additive effects with antidiabetic agents and might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Tribulus + Metformin, Linagliptini

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Ash + Metformin, Linagliptini

Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.

Read the full interaction
The complete list

Every Supplement Checked Against Metformin, Linagliptin

All 1,452 ingredients in our database, ranked by severity — 285 with a Metformin, Linagliptin interaction on file and 1,167 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Metformin, Linagliptin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ginger with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.

Full Ginger + Metformin, Linagliptin answer

Can you take Sweet Orange with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.

Full Sweet Orange + Metformin, Linagliptin answer

Can you take Milk Thistle with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking milk thistle with antidiabetes drugs may increase the risk of hypoglycemia.

Full Milk Thistle + Metformin, Linagliptin answer

Can you take Oats with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oats may have additive effects with antidiabetic agents and might increase the risk of hypoglycemia.

Full Oats + Metformin, Linagliptin answer

Can you take Tribulus with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.

Full Tribulus + Metformin, Linagliptin answer

Can you take Stereospermum with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that stereospermum can have hypoglycemic effects.

Full Stereospermum + Metformin, Linagliptin answer

Can you take Stinging Nettle with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, stinging nettle might have additive effects with antidiabetes drugs.

Full Stinging Nettle + Metformin, Linagliptin answer

Can you take Strawberry with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.

Full Strawberry + Metformin, Linagliptin answer

Can you take Sunflower Oil with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.

Full Sunflower Oil + Metformin, Linagliptin answer

Can you take Tamarind with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tamarind seed extract might have additive effects when used with antidiabetes drugs.

Full Tamarind + Metformin, Linagliptin answer

Can you take Terminalia with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and in...

Full Terminalia + Metformin, Linagliptin answer

Can you take Terminalia Bellirica with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia bellirica with antidiabetes drugs could affect blood sugar control and increase the risk of hyp...

Full Terminalia Bellirica + Metformin, Linagliptin answer

Can you take Terminalia Chebula with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypog...

Full Terminalia Chebula + Metformin, Linagliptin answer

Can you take Theaflavin with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In an animal diabetic model, giving theaflavin reduced fasting blood glucose, with an effect comparable to metformin.

Full Theaflavin + Metformin, Linagliptin answer

Can you take Thunder God Vine with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of thunder god vine constituents.

Full Thunder God Vine + Metformin, Linagliptin answer

Can you take Tinospora Cordifolia with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Tinospora Cordifolia + Metformin, Linagliptin answer

Can you take Tiratricol with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tiratricol might interfere with blood glucose control.

Full Tiratricol + Metformin, Linagliptin answer

Can you take Tragacanth with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Metformin, Linagliptin answer

Can you take Tronadora with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of tronadora and antidiabetes drugs might increase the risk of hypoglycemia.

Full Tronadora + Metformin, Linagliptin answer

Can you take Turkey Tail Mushroom with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Turkey Tail Mushroom + Metformin, Linagliptin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Metformin, Linagliptin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Metformin, Linagliptin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Metformin, Linagliptin sits in 6 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Metformin, Linagliptin through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Metformin, Linagliptin through this category.

Metformin (Glucophage) 18 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

18 of the supplement ingredients on this page reach Metformin, Linagliptin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Metformin, Linagliptin through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Metformin, Linagliptin through this category.

Organic Cation Transporter 2 (Oct2) Substrates 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Metformin, Linagliptin through this category.

Related: does Metformin, Linagliptin deplete any nutrients?

Metformin, Linagliptin has 4 reported nutrient associations in the research literature — see the Metformin, Linagliptin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Metformin, Linagliptin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Metformin, Linagliptin.

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Pharmacist Counseling Corner

Metformin, Linagliptin & Supplements: Common Questions

What supplements interact with Metformin, Linagliptin?
Our database currently documents 285 ingredients with a known Metformin, Linagliptin interaction (3 major, 242 moderate, 40 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 285. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, St. John's Wort.
Which Metformin, Linagliptin supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Metformin, Linagliptin?
Plenty of supplements coexist fine with Metformin, Linagliptin; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Jentadueto have the same supplement interactions as Metformin, Linagliptin?
Yes — Jentadueto all contain Metformin, Linagliptin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Metformin, Linagliptin deplete any vitamins or nutrients?
It might — Metformin, Linagliptin has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Metformin, Linagliptin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Metformin, Linagliptin and my other medications?
This page covers Metformin, Linagliptin against supplements and herbal ingredients. Checking Metformin, Linagliptin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.