Medication interaction hub

What Supplements Interact with Metformin, Linagliptin?

Metformin, Linagliptin brand name: Jentadueto. Every interaction below applies to the brands too.

285 Interactions 3 Major 242 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated October 6, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Metformin, Linagliptin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Metformin, Linagliptin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Siberian cocklebur is the risk anyone taking metformin and linagliptin (Jentadueto) should understand first, since it has caused severe hypoglycemia in people who consumed it. The wider picture deserves real care too. Jentadueto lowers blood sugar on two fronts, and 239 of the 285 supplements and herbs on this page can push that effect further, meaning most of this list is about the danger of dropping too low.

Only 3 entries rate major, and the other two leave you with less medicine rather than more. Activated charcoal soaks up drugs in the gut, and St. John's wort switches on a transport protein that clears linagliptin faster. Fiber supplements can slow absorption as well, so keep them well apart from your dose. The remaining 242 moderate and 40 minor entries mostly add modest glucose-lowering effects of their own, which makes extra blood sugar checks worthwhile whenever you start a new herb.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 242 Minor 40 No known interaction 1,167

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Metformin, Linagliptin: Top Interactions at a Glance

The Metformin, Linagliptin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 285 interacting ingredients — plus 1,167 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Metformin, Linagliptin Combinations Today

The Metformin, Linagliptin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Ginger + Metformin, Linagliptini

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.

Read the full interaction Moderate Likelihood Possible Melatonin + Metformin, Linagliptini

Theoretically, taking melatonin with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Probable Sida Cordifolia + Metformin, Linagliptini

Theoretically, Sida cordifolia might reduce the effectiveness of antidiabetes drugs.

Read the full interaction Minor Likelihood Unlikely Glucosamine + Metformin, Linagliptini

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Myrrh + Metformin, Linagliptini

Theoretically, myrrh might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible European Barberry + Metformin, Linagliptini

Theoretically, taking European barberry with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction
The complete list

Every Supplement Checked Against Metformin, Linagliptin

All 1,452 ingredients in our database, ranked by severity — 285 with a Metformin, Linagliptin interaction on file and 1,167 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Metformin, Linagliptin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ginger with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.

Full Ginger + Metformin, Linagliptin answer

Can you take Melatonin with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with antidiabetes drugs might increase the risk of hypoglycemia.

Full Melatonin + Metformin, Linagliptin answer

Can you take Sida Cordifolia with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Sida cordifolia might reduce the effectiveness of antidiabetes drugs.

Full Sida Cordifolia + Metformin, Linagliptin answer

Can you take Glucosamine with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.

Full Glucosamine + Metformin, Linagliptin answer

Can you take Myrrh with Metformin, Linagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, myrrh might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Myrrh + Metformin, Linagliptin answer

Can you take Cola Nut with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, metformin might increase the levels and adverse effects of the caffeine in cola nut.

Full Cola Nut + Metformin, Linagliptin answer

Can you take Devil's Claw with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, devil's claw might increase levels of P-glycoprotein substrates.

Full Devil's Claw + Metformin, Linagliptin answer

Can you take Goji with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of goji fruit polysaccharides or goji root bark with antidiabetes drugs might have additive effects.

Full Goji + Metformin, Linagliptin answer

Can you take Goli Apple Cider Vinegar Gummies with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking apple cider vinegar, which is contained in Goli ACV, with antidiabetes drugs might increase the risk of hypoglycemia (...

Full Goli Apple Cider Vinegar Gummies + Metformin, Linagliptin answer

Can you take Grapefruit with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Grapefruit juice does not seem to affect renal P-glycoprotein (P-gp).

Full Grapefruit + Metformin, Linagliptin answer

Can you take Guarana with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, metformin might increase the levels and adverse effects of caffeine.

Full Guarana + Metformin, Linagliptin answer

Can you take Ilex Guayusa with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, metformin might increase the levels and adverse effects of caffeine.

Full Ilex Guayusa + Metformin, Linagliptin answer

Can you take Karaya Gum with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Metformin, Linagliptin answer

Can you take Maqui with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, maqui fruit extract may increase the risk of hypoglycemia when used with antidiabetes drugs.

Full Maqui + Metformin, Linagliptin answer

Can you take Marshmallow with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Metformin, Linagliptin answer

Can you take Pu-erh Tea with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, metformin might increase the levels and adverse effects of caffeine.

Full Pu-erh Tea + Metformin, Linagliptin answer

Can you take Puravive with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains quercetin.

Full Puravive + Metformin, Linagliptin answer

Can you take Stevia with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.

Full Stevia + Metformin, Linagliptin answer

Can you take Uva Ursi with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.

Full Uva Ursi + Metformin, Linagliptin answer

Can you take Vitamin B12 with Metformin, Linagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.

Full Vitamin B12 + Metformin, Linagliptin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Metformin, Linagliptin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Metformin, Linagliptin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Metformin, Linagliptin sits in 6 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Metformin, Linagliptin through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Metformin, Linagliptin through this category.

Metformin (Glucophage) 18 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

18 of the supplement ingredients on this page reach Metformin, Linagliptin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Metformin, Linagliptin through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Metformin, Linagliptin through this category.

Organic Cation Transporter 2 (Oct2) Substrates 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Metformin, Linagliptin through this category.

Related: does Metformin, Linagliptin deplete any nutrients?

Metformin, Linagliptin has 4 reported nutrient associations in the research literature — see the Metformin, Linagliptin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Metformin, Linagliptin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Metformin, Linagliptin.

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Pharmacist Counseling Corner

Metformin, Linagliptin & Supplements: Common Questions

What supplements interact with Metformin, Linagliptin?
Our database currently documents 285 ingredients with a known Metformin, Linagliptin interaction (3 major, 242 moderate, 40 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 285. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, St. John's Wort.
Which Metformin, Linagliptin supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Metformin, Linagliptin?
Plenty of supplements coexist fine with Metformin, Linagliptin; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Jentadueto have the same supplement interactions as Metformin, Linagliptin?
Yes — Jentadueto all contain Metformin, Linagliptin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Metformin, Linagliptin deplete any vitamins or nutrients?
It might — Metformin, Linagliptin has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Metformin, Linagliptin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Metformin, Linagliptin and my other medications?
This page covers Metformin, Linagliptin against supplements and herbal ingredients. Checking Metformin, Linagliptin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 6, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.