Drug & supplement interaction

Fringetree + Aspirin, Butalbital, Caffeine

Aspirin, Butalbital, Caffeine brand name: Fiorinal.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Fringetree and Aspirin, Butalbital, Caffeine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Fringetree and Aspirin, Butalbital, Caffeine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Aspirin, Butalbital, Caffeine and Fringetree in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Fringetree at all — not against Aspirin, Butalbital, Caffeine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fringetree safety at a glance

Fringetree overall Use caution Human safety data are very limited, so use cautiously and under professional guidance.
Pregnancy Avoid No reliable safety data exist, so it is best avoided during pregnancy.
Breastfeeding Avoid Lack of safety information means it should be avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Aspirin, Butalbital, Caffeine and Fringetree? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Aspirin, Butalbital, Caffeine’s Own FDA Label Lists

This is not an interaction — none of it involves Fringetree. These are the most notable effects listed in the ADVERSE REACTIONS section of Aspirin, Butalbital, Caffeine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

  • A severe skin reaction Worth acting on
  • Bloating or gas
  • Drowsiness
  • Stomach upset
  • Dizziness
  • A skin rash
  • Vomiting
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Aspirin, Butalbital, Caffeine. Read the label on DailyMed › Fringetree’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Fringetree side to compare — that is a limit of the record, not a statement that Fringetree has no side effects.

Everything else you take

See Every Supplement That Interacts With Aspirin, Butalbital, Caffeine

This page covers Fringetree only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Butalbital, Caffeine page lists 347 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Ephedra (major).

By severity: 13 major · 285 moderate · 49 minor.

From our pharmacist’s overview on the Aspirin, Butalbital, Caffeine page

“The aspirin inside Fiorinal (aspirin, butalbital, caffeine) is the reason this list deserves careful reading rather than a quick skim. More than 200 of the supplements and herbs on file can thin the blood further and raise bleeding risk on top of aspirin's own antiplatelet effect, and even ordinary alcohol, beer and wine included, carr…”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Butalbital, Caffeine interaction page

One more smart check

Taking Fringetree as Part of a Dietary Supplement Product? Check It for Interactions

We hold 77 real supplement products containing Fringetree, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Fringetree. Even though Fringetree itself has no known interaction with Aspirin, Butalbital, Caffeine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Fringetree and Aspirin, Butalbital, Caffeine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fringetree
Steady interest

#958 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Butalbital, Caffeine
Top 10%

#166 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Fringetree is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fringetree reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Fringetree and Aspirin, Butalbital, Caffeine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fringetree

What is Fringetree?

  • Liver and gallbladder support
  • Digestive complaints
  • Jaundice
  • Gallstones
  • Bitter tonic

Fringetree is a North American shrub whose root and stem bark have long been used in traditional herbal medicine, mainly for liver, gallbladder, and digestive complaints. There is very little modern human research to confirm any of these uses, so its benefits remain unproven and its safety is not well established. Talk with a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Chionanthus virginicus · Oleaceae · Dried root and stem bark · Tincture, liquid extract, capsules, dried bark for decoction

An interaction check asks whether these two react with each other — it does not ask whether Fringetree is a good idea for someone in your situation. Here is what our Fringetree record says about it on its own.

Fringetree: dosing

There is no established, standardized dose for fringetree. Traditional sources used the tincture or a decoction of the bark, but reliable modern dosing guidelines do not exist.If you choose to use a fringetree product, follow the directions on the product label and do not exceed them.

From our Fringetree monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fringetree monograph & all interactions
Medication

About Aspirin, Butalbital, and Caffeine

What Is Aspirin, Butalbital, and Caffeine Used For?

Brand name: Fiorinal

This combination is used to relieve the symptoms of tension (or muscle contraction) headache. The supported product is the oral capsule.

There is no evidence that it works or is safe for multiple recurrent headaches. Caution is needed because butalbital is habit-forming and can be abused.

See full Aspirin, Butalbital, and Caffeine drug information
Keep checking

Other Drugs & Fringetree

Browse every other medication we’ve checked against Fringetree — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Fringetree against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Fringetree list.

See the full Fringetree interactions page
See every supplement checked against Aspirin, Butalbital, Caffeine, ranked by severity
Evidence & sources

Fringetree References

The 2 sources that drive our Fringetree monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Fringetree is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH NCCIH Source
  2. Herbs and Supplements — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fringetree and Aspirin, Butalbital, Caffeine Together: Common Questions

Is it safe to take Fringetree with Aspirin, Butalbital, Caffeine?
We do not list a known interaction between Fringetree and Aspirin, Butalbital, Caffeine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Aspirin, Butalbital, Caffeine interact with any supplements?
Yes. Aspirin, Butalbital, Caffeine has documented interactions with 347 supplements in our database — Fringetree is not one of them. The Aspirin, Butalbital, Caffeine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fringetree monograph Uses, safety profile, and every drug interaction in one place Aspirin, Butalbital, and Caffeine drug information The full plain-English guide to this medication Aspirin, Butalbital, Caffeine supplement interactions Every supplement checked against Aspirin, Butalbital, Caffeine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Aspirin, Butalbital, Caffeine and Fringetree?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.