Medication interaction hub

What Supplements Interact with Aspirin, Butalbital, Caffeine?

Aspirin, Butalbital, Caffeine brand name: Fiorinal. Every interaction below applies to the brands too.

347 Interactions 13 Major 285 Moderate 49 Minor
Curated & coded by · Clinical Pharmacist · Updated September 18, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Aspirin, Butalbital, Caffeine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Aspirin, Butalbital, Caffeine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

The aspirin inside Fiorinal (aspirin, butalbital, caffeine) is the reason this list deserves careful reading rather than a quick skim. More than 200 of the supplements and herbs on file can thin the blood further and raise bleeding risk on top of aspirin's own antiplatelet effect, and even ordinary alcohol, beer and wine included, carries a major rating for gastrointestinal bleeding. A second large cluster piles onto the caffeine component, adding jitteriness, faster heart rate, and higher blood pressure, with stimulant herbs like ephedra rated major.

A third group changes how much medicine actually reaches you. St. John's wort speeds the drug's breakdown and lowers its levels, while grapefruit slows it and pushes levels up. I would learn the 13 major-rated entries first. The remaining 285 moderate and 49 minor ones are worth a scan afterward, but the majors are where the real danger sits.

— , Clinical Pharmacist · July 18, 2026

Major 13 Moderate 285 Minor 49 No known interaction 1,105

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Aspirin, Butalbital, Caffeine: Top Interactions at a Glance

The Aspirin, Butalbital, Caffeine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 347 interacting ingredients — plus 1,105 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Aspirin, Butalbital, Caffeine Combinations Today

The Aspirin, Butalbital, Caffeine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Fish Oil + Aspirin, Butalbital, Caffeinei

Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Alpha-lipoic Acid + Aspirin, Butalbital, Caffeinei

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Niacin + Aspirin, Butalbital, Caffeinei

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Bromelain + Aspirin, Butalbital, Caffeinei

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Minor Likelihood Unlikely Magnesium + Aspirin, Butalbital, Caffeinei

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Read the full interaction Moderate Likelihood Possible Dong Quai + Aspirin, Butalbital, Caffeinei

Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflicting.

Read the full interaction
The complete list

Every Supplement Checked Against Aspirin, Butalbital, Caffeine

All 1,452 ingredients in our database, ranked by severity — 347 with a Aspirin, Butalbital, Caffeine interaction on file and 1,105 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Aspirin, Butalbital, Caffeine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Fish Oil with Aspirin, Butalbital, Caffeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Fish Oil + Aspirin, Butalbital, Caffeine answer

Can you take Alpha-lipoic Acid with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplate...

Full Alpha-lipoic Acid + Aspirin, Butalbital, Caffeine answer

Can you take Niacin with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Full Niacin + Aspirin, Butalbital, Caffeine answer

Can you take Bromelain with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Bromelain + Aspirin, Butalbital, Caffeine answer

Can you take Magnesium with Aspirin, Butalbital, Caffeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Full Magnesium + Aspirin, Butalbital, Caffeine answer

Can you take Evening Primrose with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evening primrose oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Evening Primrose + Aspirin, Butalbital, Caffeine answer

Can you take False Unicorn with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + Aspirin, Butalbital, Caffeine answer

Can you take Fasting with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Fasting may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Fasting + Aspirin, Butalbital, Caffeine answer

Can you take Fennel with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Aspirin, Butalbital, Caffeine answer

Can you take Feverfew with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.

Full Feverfew + Aspirin, Butalbital, Caffeine answer

Can you take Flaxseed with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of b...

Full Flaxseed + Aspirin, Butalbital, Caffeine answer

Can you take Flaxseed Oil with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk...

Full Flaxseed Oil + Aspirin, Butalbital, Caffeine answer

Can you take Fo-ti with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase or decrease the levels and clinical effects of drugs metabolized by CYP1A2.

Full Fo-ti + Aspirin, Butalbital, Caffeine answer

Can you take Fulvic Acid with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fulvic acid may decrease the effectiveness of anticoagulant and antiplatelet drugs.

Full Fulvic Acid + Aspirin, Butalbital, Caffeine answer

Can you take Gamma-linolenic Acid (gla) with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, GLA might increase the risk of bleeding when taken with anticoagulant or antiplatelet rugs.

Full Gamma-linolenic Acid (gla) + Aspirin, Butalbital, Caffeine answer

Can you take Garcinia with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplat...

Full Garcinia + Aspirin, Butalbital, Caffeine answer

Can you take Garden Cress with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, garden cress seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Garden Cress + Aspirin, Butalbital, Caffeine answer

Can you take Garlic with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.

Full Garlic + Aspirin, Butalbital, Caffeine answer

Can you take Genistein Combined Polysaccharide with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, genistein combined polysaccharide might reduce the clearance of caffeine.

Full Genistein Combined Polysaccharide + Aspirin, Butalbital, Caffeine answer

Can you take German Chamomile with Aspirin, Butalbital, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Aspirin, Butalbital, Caffeine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Aspirin, Butalbital, Caffeine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Aspirin, Butalbital, Caffeine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Aspirin, Butalbital, Caffeine sits in 13 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Aspirin, Butalbital, Caffeine through this category.

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Aspirin, Butalbital, Caffeine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Aspirin, Butalbital, Caffeine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Aspirin, Butalbital, Caffeine through this category.

Aspirin 22 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

22 of the supplement ingredients on this page reach Aspirin, Butalbital, Caffeine through this category.

Caffeine 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Butalbital, Caffeine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Butalbital, Caffeine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Butalbital, Caffeine through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Butalbital, Caffeine through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Butalbital, Caffeine through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Butalbital, Caffeine through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Butalbital, Caffeine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Aspirin, Butalbital, Caffeine through this category.

About Aspirin, Butalbital, Caffeine

Aspirin, butalbital, and caffeine is a combination medicine used to relieve tension headaches.

Generic name: Aspirin, Butalbital, Caffeine  ·  Brand name: Fiorinal.

See the full Aspirin, Butalbital, and Caffeine drug information

Related: does Aspirin, Butalbital, Caffeine deplete any nutrients?

Aspirin, Butalbital, Caffeine has 5 reported nutrient associations in the research literature — see the Aspirin, Butalbital, Caffeine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Aspirin, Butalbital, Caffeine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Aspirin, Butalbital, Caffeine.

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Pharmacist Counseling Corner

Aspirin, Butalbital, Caffeine & Supplements: Common Questions

What supplements interact with Aspirin, Butalbital, Caffeine?
More than you might expect — 347 in total, though they are far from equal: 13 are rated major, 285 moderate, and 49 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Aspirin, Butalbital, Caffeine supplement interactions are the most serious?
Focus on the major group: Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and Danshen, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Aspirin, Butalbital, Caffeine?
Usually yes — most people on Aspirin, Butalbital, Caffeine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Fiorinal have the same supplement interactions as Aspirin, Butalbital, Caffeine?
Yes — Fiorinal all contain Aspirin, Butalbital, Caffeine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Aspirin, Butalbital, Caffeine deplete any vitamins or nutrients?
It might — Aspirin, Butalbital, Caffeine has 5 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Aspirin, Butalbital, Caffeine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Aspirin, Butalbital, Caffeine and my other medications?
This page covers Aspirin, Butalbital, Caffeine against supplements and herbal ingredients. Checking Aspirin, Butalbital, Caffeine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Aspirin, Butalbital, and Caffeine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 18, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.