Gamma Butyrolactone (gbl) - Entyvio (Vedolizumab) Interaction
Herbal: Gamma Butyrolactone (gbl)
Also Known As: 2-3 dihydro furanone
Drug: Vedolizumab
Brand names:
Entyvio
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
There were no interactions found between Vedolizumab and Gamma Butyrolactone (gbl). This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Gamma Butyrolactone (gbl) Overview
Gamma butyrolactone (GBL) is a chemical compound found in a wide range of industrial products, including cleaning solutions and nail varnish. Its main use is as a solvent and reagent. If consumed, GBL is metabolized to gamma-hydroxybutyrate (GHB), a potent sedative that can produce relaxation, euphoria and hallucinations. GHB is commonly known as the 'date-rape drug'. The use of GBL for medicinal purposes is not recommended. GBL is federally classified as a Schedule I controlled substance in the United States, making its production, sale, and possession illegal.
Vedolizumab Overview
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Vedolizumab injection is used to relieve the symptoms of certain autoimmune disorders (conditions in which the immune system attacks healthy parts of the body and causes pain, swelling, and damage) of the gastrointestinal tract including:
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Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever) that has not improved when treated with other medications.
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ulcerative colitis (condition that causes swelling and sores in the lining of the large intestine) that has not improved when treated with other medications.
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Vedolizumab injection is in a class of medications called integrin receptor antagonists. It works by blocking the action of certain cells in the body that cause inflammation.
Gamma Butyrolactone (gbl) - More Interactions
Gamma Butyrolactone (gbl) interacts with 268 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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