Drug & supplement interaction

Gentian + Uridine Triacetate

Uridine Triacetate brand names: Xuriden, Vistogard.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Gentian and Uridine Triacetate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Uridine Triacetate states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Gentian and Uridine Triacetate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Uridine Triacetate and Gentian in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Gentian safety at a glance

Gentian overall Use caution Generally tolerated in small amounts by healthy adults, but it can upset the stomach and is not well studied at high doses.
Pregnancy Avoid Not enough safety data, and traditional cautions exist, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough reliable safety information, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Uridine Triacetate and Gentian? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Uridine Triacetate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Uridine Triacetate is filed under a single classification — oral drugs. Gentian has documented interactions with 1 drug class — the most serious being antihypertensive drugs (moderate) — and none of Uridine Triacetate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Gentian Does Interact With Other Medications

Gentian has 172 moderate known drug interactions in our database — Uridine Triacetate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Uridine Triacetate)
Taking anything else?

Check Another of Your Medications Against Gentian

Covers the 2,830 medications we’ve checked against Gentian. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Gentian and Uridine Triacetate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea / Vomiting / Nausea reported in 15.2% of FDA reports for Uridine Triacetate Additional detail

    Gentian

    “Orally, gentian root, in combination with other herbs, has been reported to cause gastrointestinal adverse effects. Gastrointestinal intolerance occurred in patients with cancer-associated anorexia who took gentian tincture 1 mL three times daily, in conjunction with turmeric 1 gram and ginger 1 gram twice daily, for 14 days.”

    Gentian · Natural Medicines adverse-effect record, reported in anorexia.

    3 sources cited
    1. 374. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
    2. 379. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
    3. 96263. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

    Uridine Triacetate

    Listed in the ADVERSE REACTIONS section of the FDA label for Uridine Triacetate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Gentian but not commonly for Uridine Triacetate: bloating or gas and reduced appetite.

Effects for Uridine Triacetate come from the ADVERSE REACTIONS section of its FDA label; effects for Gentian come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 138 voluntary FDA FAERS reports for Uridine Triacetate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Uridine Triacetate Products Have a Food Rule — Gentian Should Not Break It

At least one FDA label for a product containing Uridine Triacetate says to take it with food. If you take Gentian on an empty stomach out of habit, keep them separate — and take Uridine Triacetate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Uridine Triacetate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Administer the dose with food (applesauce, pudding or yogurt) or in milk or infant formula.

From the Dosage and Administration section of the FDA label we read for Uridine Triacetate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Uridine Triacetate

This page covers Gentian only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Uridine Triacetate page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Uridine Triacetate page

“Uridine triacetate is a drug you take when absorption truly cannot fail, whether as Vistogard, the emergency antidote for fluorouracil or capecitabine overdose, or as Xuriden for hereditary orotic aciduria. That is why the 17 supplement interactions on file deserve real care rather than a shrug.”

Reviewed by 2 · Jul 18, 2026

Open the Uridine Triacetate interaction page

One more smart check

Taking Gentian as Part of a Dietary Supplement Product? Check It for Interactions

We hold 749 real supplement products containing Gentian, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Gentian. Even though Gentian itself has no known interaction with Uridine Triacetate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Gentian and Uridine Triacetate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gentian
Top 25%

#217 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Uridine Triacetate
Steady interest

#2,402 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Gentian reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Gentian and Uridine Triacetate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Gentian

What is Gentian?

  • Loss of appetite
  • Indigestion and bloating
  • Digestive bitter tonic
  • Stomach upset
  • Sluggish digestion

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and preliminary, and while short-term use of normal amounts appears generally well tolerated in healthy adults, anyone with ulcers, reflux, or who is pregnant should be cautious and check with a pharmacist or doctor first.

Gentiana lutea · Gentianaceae · Root and rhizome · Tinctures, liquid extracts, teas, bitters, capsules, dried root

An interaction check asks whether these two react with each other — it does not ask whether Gentian is a good idea for someone in your situation. Here is what our Gentian record says about it on its own.

Gentian: dosing

There is no official, standardized dose for gentian, and products vary widely in strength. Traditional use involves small amounts of a tincture, extract, or tea taken shortly before meals.Because formulations differ, the safest approach is to follow the directions on the product label and not exceed the suggested amount. A pharmacist can help you choose a reasonable product and dose, and can review it against your other medicines and health conditions.

From our Gentian monograph — the full record covers uses, side effects and every documented interaction.

Read the full Gentian monograph & all interactions
Medication

About Uridine Triacetate

What Is Uridine Triacetate Used For?

Brand names: Xuriden, Vistogard

Uridine triacetate is available as two different products for two distinct uses. Vistogard is used for emergency treatment after an overdose of the chemotherapy drugs fluorouracil or capecitabine — or when someone develops severe, early, or life-threatening side effects from those drugs (such as heart or nervous system problems, severe digestive reactions, or a dangerous drop in white blood cells) within 96 hours of their last dose.

Xuriden is used to treat hereditary orotic aciduria, a rare inherited condition in which the body cannot make enough of a building block called uridine, causing a buildup of orotic acid and problems with blood cell production and other body functions. Both products are approved for adults and children.

See full Uridine Triacetate drug information
Keep checking

Other Drugs & Gentian

Browse every other medication we’ve checked against Gentian — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Gentian page.

No interaction 2,657 drugs checked — show the list

We also checked Gentian against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Gentian list.

See the full Gentian interactions page
See every supplement checked against Uridine Triacetate, ranked by severity
Evidence & sources

Gentian References

The 5 references that drive our Gentian monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
  4. Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
  5. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Gentian and Uridine Triacetate Together: Common Questions

Is it safe to take Gentian with Uridine Triacetate?
We do not list a known interaction between Gentian and Uridine Triacetate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Gentian and Uridine Triacetate have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Gentian and Uridine Triacetate at the same time of day?
At least one FDA label for a product containing Uridine Triacetate says to take it with food. If you take Gentian on an empty stomach out of habit, keep them separate and take Uridine Triacetate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Uridine Triacetate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Gentian and Uridine Triacetate combination checked?
Interactions in our licensed database are recorded against drug classes. Uridine Triacetate is filed under 1 classification, and Gentian has documented interactions with 1 drug class — none of Uridine Triacetate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Gentian interact with any other medications?
Yes. Gentian has 172 documented drug interactions in our database — Uridine Triacetate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Uridine Triacetate interact with any supplements?
Yes. Uridine Triacetate has documented interactions with 17 supplements in our database — Gentian is not one of them. The Uridine Triacetate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Gentian monograph Uses, safety profile, and every drug interaction in one place Uridine Triacetate drug information The full plain-English guide to this medication Uridine Triacetate supplement interactions Every supplement checked against Uridine Triacetate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Uridine Triacetate and Gentian?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.