Drug & supplement interaction

Goat's Rue + Methyclothiazide, Reserpine

Methyclothiazide, Reserpine brand name: Diutensen-R.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Goat's Rue and Methyclothiazide, Reserpine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Goat's Rue and Methyclothiazide, Reserpine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methyclothiazide, Reserpine and Goat's Rue in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Goat's Rue safety at a glance

Goat's Rue overall Use caution The fresh plant can be toxic, and well-controlled human safety data on supplements are limited.
Pregnancy Avoid Not enough safety data exists, so it is best avoided during pregnancy.
Breastfeeding Use caution It is traditionally used to support milk supply, but quality and safety vary, so use only with professional guidance.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methyclothiazide, Reserpine and Goat's Rue? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Methyclothiazide, Reserpine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Methyclothiazide, Reserpine is filed under 8 classifications — including alpha-adrenergic antagonists, thiazide diuretics, diuretic drugs. Goat's Rue has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Methyclothiazide, Reserpine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Goat's Rue Does Interact With Other Medications

Goat's Rue has 122 moderate known drug interactions in our database — Methyclothiazide, Reserpine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Methyclothiazide, Reserpine)
Taking anything else?

Check Another of Your Medications Against Goat's Rue

Covers the 2,830 medications we’ve checked against Goat's Rue. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Methyclothiazide, Reserpine

This page covers Goat's Rue only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methyclothiazide, Reserpine page lists 228 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 193 moderate · 25 minor.

From our pharmacist’s overview on the Methyclothiazide, Reserpine page

“Diutensen-R pairs methyclothiazide, a thiazide diuretic, with reserpine, and both halves work to pull blood pressure down, which is why the 228 supplement and herbal interactions on file here deserve genuine vigilance. Most entries either push blood pressure lower than intended or deepen the diuretic effect, draining more fluid and pot…”

Reviewed by 2 · Jul 18, 2026

Open the Methyclothiazide, Reserpine interaction page

One more smart check

Taking Goat's Rue as Part of a Dietary Supplement Product? Check It for Interactions

We hold 80 real supplement products containing Goat's Rue, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Goat's Rue. Even though Goat's Rue itself has no known interaction with Methyclothiazide, Reserpine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Goat's Rue and Methyclothiazide, Reserpine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Goat's Rue
Steady interest

#797 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methyclothiazide, Reserpine
Steady interest

#2,308 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Goat's Rue reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Goat's Rue and Methyclothiazide, Reserpine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Goat's Rue

What is Goat's Rue?

Goat's Rue
  • Boosting breast milk supply
  • Blood sugar support
  • Traditional digestive remedy
  • General tonic

Goat's rue is a traditional herb most often used by nursing parents to try to increase milk supply, and it has a historical link to diabetes research. Solid human evidence for either use is limited, and the plant can be toxic in larger amounts, so use it only under the guidance of a pharmacist or doctor.

Galega officinalis · Fabaceae · Above-ground parts (leaves, flowering tops, and seeds) · Tea, capsules, tincture, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Goat's Rue is a good idea for someone in your situation. Here is what our Goat's Rue record says about it on its own.

Goat's Rue: dosing

There is no well-established, standardized dose for goat's rue. Do not exceed the recommended amount, and choose products from reputable brands.

From our Goat's Rue monograph — the full record covers uses, side effects and every documented interaction.

Read the full Goat's Rue monograph & all interactions
Keep checking

Other Drugs & Goat's Rue

Browse every other medication we’ve checked against Goat's Rue — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Goat's Rue page.

No interaction 2,707 drugs checked — show the list

We also checked Goat's Rue against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Goat's Rue list.

See the full Goat's Rue interactions page
See every supplement checked against Methyclothiazide, Reserpine, ranked by severity
Evidence & sources

Goat's Rue References

The 6 references that drive our Goat's Rue monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Atanasov AT. Effect of Galega officinalis L. extract on platelet aggregation in rats. J Herbs Spices Med Plants 1995;3:71-6.
  2. Atanasov, A. T. and Spasov, V. Inhibiting effect of desalted extract from Galega officinalis L. on platelet aggregation. Folia Med.(Plovdiv.) 1999;41(1):46-50.
  3. Atanasov, A. T. and Spasov, V. Inhibiting and disaggregating effect of gel-filtered Galega officinalis L. herbal extract on platelet aggregation. J.Ethnopharmacol. 2000;69(3):235-240. PubMed
  4. Atanasov, A. T. and Tchorbanov, B. Anti-platelet fraction from Galega officinalis L. inhibits platelet aggregation. J.Med.Food 2002;5(4):229-234.
  5. Atanasov, A. T. and Tchorbanov, B. J. Antiplatelet aggregation activity of a fraction isolated from Galega officinalis L. J Herbs Spices Medicinal Plant 2002;10(2):63-71.
  6. Salatino S, Giacomelli L, Carnevali I, Giacomelli E. The role of natural galactagogues during breast feeding: focus on a Galega officinalis based food supplement. Minerva Pediatr. 2017 Dec;69(6):531-537. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Goat's Rue and Methyclothiazide, Reserpine Together: Common Questions

Is it safe to take Goat's Rue with Methyclothiazide, Reserpine?
We do not list a known interaction between Goat's Rue and Methyclothiazide, Reserpine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Goat's Rue and Methyclothiazide, Reserpine combination checked?
Interactions in our licensed database are recorded against drug classes. Methyclothiazide, Reserpine is filed under 8 classifications, and Goat's Rue has documented interactions with 1 drug class — none of Methyclothiazide, Reserpine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Goat's Rue interact with any other medications?
Yes. Goat's Rue has 122 documented drug interactions in our database — Methyclothiazide, Reserpine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Methyclothiazide, Reserpine interact with any supplements?
Yes. Methyclothiazide, Reserpine has documented interactions with 228 supplements in our database — Goat's Rue is not one of them. The Methyclothiazide, Reserpine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Goat's Rue monograph Uses, safety profile, and every drug interaction in one place Methyclothiazide, Reserpine supplement interactions Every supplement checked against Methyclothiazide, Reserpine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.