Drug & supplement interaction

Goat's Rue + Ranitidine

Ranitidine brand names: Zantac 150 EFFER, Zantac 150 GEL, Zantac 150, Zantac Geldose, Zantac, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Goat's Rue and Ranitidine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Goat's Rue and Ranitidine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ranitidine and Goat's Rue in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Goat's Rue safety at a glance

Goat's Rue overall Use caution The fresh plant can be toxic, and well-controlled human safety data on supplements are limited.
Pregnancy Avoid Not enough safety data exists, so it is best avoided during pregnancy.
Breastfeeding Use caution It is traditionally used to support milk supply, but quality and safety vary, so use only with professional guidance.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ranitidine and Goat's Rue? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ranitidine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ranitidine is filed under 6 classifications — including h2-blockers, cytochrome p450 2d6 (cyp2d6) inhibitors, organic anion transporter 3 (oat3) substrates. Goat's Rue has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Ranitidine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Goat's Rue Does Interact With Other Medications

Goat's Rue has 122 moderate known drug interactions in our database — Ranitidine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Ranitidine)
Taking anything else?

Check Another of Your Medications Against Goat's Rue

Covers the 2,830 medications we’ve checked against Goat's Rue. Pick one to open its full report.

What to actually watch for

What Ranitidine’s Own FDA Label Lists

This is not an interaction — none of it involves Goat's Rue. These are the most notable effects listed in the ADVERSE REACTIONS section of Ranitidine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • A slow heartbeat Worth acting on
  • Hallucinations Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • An irregular heartbeat Worth acting on
  • Wheezing Worth acting on
  • Confusion Worth acting on
  • A severe skin reaction Worth acting on
  • Low mood Worth acting on
  • A low platelet count Worth acting on

Showing the 10 most notable of 37 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Ranitidine. Read the label on DailyMed › Where a percentage is shown, it is the share of 230,801 voluntary FDA FAERS reports for Ranitidine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Goat's Rue’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Goat's Rue side to compare — that is a limit of the record, not a statement that Goat's Rue has no side effects.

From our Q&A

Questions About Goat's Rue or Ranitidine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Goat's Rue or Ranitidine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ranitidine

This page covers Goat's Rue only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ranitidine page lists 74 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), African Wild Potato (moderate), Banderol (moderate) and Beer (moderate).

By severity: 2 major · 43 moderate · 29 minor.

From our pharmacist’s overview on the Ranitidine page

“Ranitidine (Zantac) is a heartburn and ulcer medicine gentle enough to have sold over the counter, but two of the 74 supplements and herbs on file with it earn real caution and are worth understanding first. Activated charcoal can soak up ranitidine in the gut and blunt the dose, and St.”

Reviewed by 2 · Jul 18, 2026

Open the Ranitidine interaction page

One more smart check

Taking Goat's Rue as Part of a Dietary Supplement Product? Check It for Interactions

We hold 80 real supplement products containing Goat's Rue, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Goat's Rue. Even though Goat's Rue itself has no known interaction with Ranitidine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Goat's Rue and Ranitidine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Goat's Rue
Top half

#654 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ranitidine
Top half

#1,258 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Goat's Rue reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Goat's Rue and Ranitidine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Goat's Rue

What is Goat's Rue?

Goat's Rue
  • Boosting breast milk supply
  • Blood sugar support
  • Traditional digestive remedy
  • General tonic

Goat's rue is a traditional herb most often used by nursing parents to try to increase milk supply, and it has a historical link to diabetes research. Solid human evidence for either use is limited, and the plant can be toxic in larger amounts, so use it only under the guidance of a pharmacist or doctor.

Galega officinalis · Fabaceae · Above-ground parts (leaves, flowering tops, and seeds) · Tea, capsules, tincture, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Goat's Rue is a good idea for someone in your situation. Here is what our Goat's Rue record says about it on its own.

Goat's Rue: dosing

There is no well-established, standardized dose for goat's rue. Do not exceed the recommended amount, and choose products from reputable brands.

From our Goat's Rue monograph — the full record covers uses, side effects and every documented interaction.

Read the full Goat's Rue monograph & all interactions
Medication

About Ranitidine

What Is Ranitidine Used For?

Brand names: Zantac 150 EFFER, Zantac 150 GEL, Zantac 150, Zantac Geldose, Zantac, Ranit, Zantac Efferdose, Zantac 300, Zantac 300 GEL, Ranitidine injection

Ranitidine treats a range of stomach acid–related conditions. Prescription-strength ranitidine (capsules, tablets, and oral solution) is used for active duodenal ulcers (ulcers in the small intestine), active benign gastric ulcers (stomach ulcers), GERD (acid reflux disease), erosive esophagitis (acid damage to the esophagus), and pathological hypersecretory conditions — rare disorders where the stomach makes far too much acid, such as Zollinger-Ellison syndrome. It is also used as maintenance therapy to keep duodenal and gastric ulcers from coming back after they have healed.

Over-the-counter products — including Acid Reducer and Acid Reducer 150 tablets — are approved to relieve heartburn associated with acid indigestion and sour stomach, and to prevent that heartburn when taken before eating or drinking foods that trigger it.

Most-Reported Side Effects for Ranitidine

From FAERS, the FDA’s public side-effect reporting system (230,801 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Breast cancer 29,413 reports
Prostate cancer 26,446 reports
Colorectal cancer 20,720 reports
Bladder cancer 19,207 reports
Renal cancer 19,035 reports
See full Ranitidine drug information
Keep checking

Other Drugs & Goat's Rue

Browse every other medication we’ve checked against Goat's Rue — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Goat's Rue page.

No interaction 2,707 drugs checked — show the list

We also checked Goat's Rue against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Goat's Rue list.

See the full Goat's Rue interactions page
See every supplement checked against Ranitidine, ranked by severity
Evidence & sources

Goat's Rue References

The 6 references that drive our Goat's Rue monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Atanasov AT. Effect of Galega officinalis L. extract on platelet aggregation in rats. J Herbs Spices Med Plants 1995;3:71-6.
  2. Atanasov, A. T. and Spasov, V. Inhibiting effect of desalted extract from Galega officinalis L. on platelet aggregation. Folia Med.(Plovdiv.) 1999;41(1):46-50.
  3. Atanasov, A. T. and Spasov, V. Inhibiting and disaggregating effect of gel-filtered Galega officinalis L. herbal extract on platelet aggregation. J.Ethnopharmacol. 2000;69(3):235-240. PubMed
  4. Atanasov, A. T. and Tchorbanov, B. Anti-platelet fraction from Galega officinalis L. inhibits platelet aggregation. J.Med.Food 2002;5(4):229-234.
  5. Atanasov, A. T. and Tchorbanov, B. J. Antiplatelet aggregation activity of a fraction isolated from Galega officinalis L. J Herbs Spices Medicinal Plant 2002;10(2):63-71.
  6. Salatino S, Giacomelli L, Carnevali I, Giacomelli E. The role of natural galactagogues during breast feeding: focus on a Galega officinalis based food supplement. Minerva Pediatr. 2017 Dec;69(6):531-537. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Goat's Rue and Ranitidine Together: Common Questions

Is it safe to take Goat's Rue with Ranitidine?
We do not list a known interaction between Goat's Rue and Ranitidine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Goat's Rue and Ranitidine combination checked?
Interactions in our licensed database are recorded against drug classes. Ranitidine is filed under 6 classifications, and Goat's Rue has documented interactions with 1 drug class — none of Ranitidine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Goat's Rue interact with any other medications?
Yes. Goat's Rue has 122 documented drug interactions in our database — Ranitidine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ranitidine interact with any supplements?
Yes. Ranitidine has documented interactions with 74 supplements in our database — Goat's Rue is not one of them. The Ranitidine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Goat's Rue monograph Uses, safety profile, and every drug interaction in one place Ranitidine drug information The full plain-English guide to this medication Ranitidine supplement interactions Every supplement checked against Ranitidine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ranitidine and Goat's Rue?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.