Drug & supplement interaction

Gras + Diphenhydramine Hydrochloride, Naproxen Sodium

Diphenhydramine Hydrochloride, Naproxen Sodium brand name: Aleve PM.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Gras and Diphenhydramine Hydrochloride, Naproxen Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Diphenhydramine Hydrochloride, Naproxen Sodium states a food rule worth keeping to.

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Interaction report

Gras and Diphenhydramine Hydrochloride, Naproxen Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diphenhydramine Hydrochloride, Naproxen Sodium and Gras in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Gras at all — not against Diphenhydramine Hydrochloride, Naproxen Sodium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Gras safety at a glance

Gras overall Not established We cannot confirm what "Gras" is, so its safety is unknown.
Pregnancy Avoid Because the product is unidentified, avoid it during pregnancy unless a doctor confirms it is safe.
Breastfeeding Avoid With no reliable information, avoid it while breastfeeding unless cleared by your doctor.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diphenhydramine Hydrochloride, Naproxen Sodium and Gras? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How to take them

Some Diphenhydramine Hydrochloride, Naproxen Sodium Products Have a Food Rule — Gras Should Not Break It

At least one FDA label for a product containing Diphenhydramine Hydrochloride, Naproxen Sodium says to take it with food. If you take Gras on an empty stomach out of habit, keep them separate — and take Diphenhydramine Hydrochloride, Naproxen Sodium with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Diphenhydramine Hydrochloride, Naproxen Sodium products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Directions • do not take more than directed • drink a full glass of water with each dose • adults and children 12 years and over: take 2 caplets at bedtime • do not take more than 2 caplets in 24 hours • if taken with food, this product may take longer to work

From the Dosage and Administration section of the FDA label we read for Diphenhydramine Hydrochloride, Naproxen Sodium — where that label names a specific product, the instruction is that product's.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Diphenhydramine Hydrochloride, Naproxen Sodium

This page covers Gras only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diphenhydramine Hydrochloride, Naproxen Sodium page lists 378 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 13 major · 320 moderate · 45 minor.

From our pharmacist’s overview on the Diphenhydramine Hydrochloride, Naproxen Sodium page

“Aleve PM combines naproxen, an NSAID, with the sedating antihistamine diphenhydramine, and its supplement list earns genuine care rather than a quick skim. Thirteen of the 378 ingredients on file rate major, and the two largest themes track the pill's two halves.”

Reviewed by 2 · Jul 18, 2026

Open the Diphenhydramine Hydrochloride, Naproxen Sodium interaction page

How much people look this up

Where Gras and Diphenhydramine Hydrochloride, Naproxen Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gras
Steady interest

#996 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diphenhydramine Hydrochloride, Naproxen Sodium
Top 25%

#287 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Gras is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Gras reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Gras and Diphenhydramine Hydrochloride, Naproxen Sodium records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Gras

What is Gras?

We could not find reliable information about a dietary supplement or herb called "Gras." The name may be a misspelling, a brand name, or a local/regional term, so we cannot confirm what it is, what it does, or whether it is safe. Please double-check the name with your pharmacist or the product label before using it.

An interaction check asks whether these two react with each other — it does not ask whether Gras is a good idea for someone in your situation. Here is what our Gras record says about it on its own.

Gras: dosing

There is no established or recommended dose for "Gras" because the product cannot be reliably identified. We will not guess an amount. If you have a labeled product, follow the manufacturer's instructions only after confirming the actual ingredient with a pharmacist or doctor.

From our Gras monograph — the full record covers uses, side effects and every documented interaction.

Read the full Gras monograph & all interactions
Keep checking

Other Drugs & Gras

Browse every other medication we’ve checked against Gras — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Gras against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Gras list.

See the full Gras interactions page
See every supplement checked against Diphenhydramine Hydrochloride, Naproxen Sodium, ranked by severity
Evidence & sources

Gras References

The 3 sources that drive our Gras monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Gras is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Dietary and Herbal Supplements — NIH NCCIH Source
  2. Herbs and Supplements — MedlinePlus Source
  3. Generally Recognized as Safe (GRAS) — U.S. Food and Drug Administration Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Gras and Diphenhydramine Hydrochloride, Naproxen Sodium Together: Common Questions

Is it safe to take Gras with Diphenhydramine Hydrochloride, Naproxen Sodium?
We do not list a known interaction between Gras and Diphenhydramine Hydrochloride, Naproxen Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Gras and Diphenhydramine Hydrochloride, Naproxen Sodium at the same time of day?
At least one FDA label for a product containing Diphenhydramine Hydrochloride, Naproxen Sodium says to take it with food. If you take Gras on an empty stomach out of habit, keep them separate and take Diphenhydramine Hydrochloride, Naproxen Sodium with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Diphenhydramine Hydrochloride, Naproxen Sodium products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Diphenhydramine Hydrochloride, Naproxen Sodium interact with any supplements?
Yes. Diphenhydramine Hydrochloride, Naproxen Sodium has documented interactions with 378 supplements in our database — Gras is not one of them. The Diphenhydramine Hydrochloride, Naproxen Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Gras monograph Uses, safety profile, and every drug interaction in one place Diphenhydramine Hydrochloride, Naproxen Sodium supplement interactions Every supplement checked against Diphenhydramine Hydrochloride, Naproxen Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diphenhydramine Hydrochloride, Naproxen Sodium and Gras?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.