Greater Celandine + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine
Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine brand name: Vicks NyQuil.
Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine falls into 2 drug categories that Greater Celandine can interact with; the most serious is rated moderate. Research in vitro shows that chelidonine, a constituent of greater celandine, inhibits cytochrome P450 2D6 (CYP2D6) enzyme activity.
Read the full interaction reportGreater Celandine and Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine
These two interact in 2 distinct ways. Each one is explained separately below.
Why Are There 2 Interactions?
Greater Celandine interacts with whole categories of medication. Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine falls into 2 of those categories, so it can interact with Greater Celandine in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
1 of 2Why this applies to Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine
Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES — the group Greater Celandine interacts with.
Some drugs metabolized by CYP2D6 include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and many others.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
The piece of NyQuil that matters here is the dextromethorphan (the cough suppressant). Your liver uses an enzyme called CYP2D6 to clear it. Greater celandine contains a compound (chelidonine) that may block that same enzyme, so in theory dextromethorphan could build up and hit you harder than expected. That might mean more drowsiness, dizziness, confusion, or a jittery, off feeling. The doxylamine in NyQuil already makes you sleepy, so the combo could feel stronger.
Honestly though, this is based only on lab testing, not real people, so it's a soft maybe. The bigger worry is that greater celandine itself has been tied to serious liver injury, and acetaminophen is also processed by the liver. I'd skip the celandine and check with your pharmacist first.
- Liu Y, Cui T, Peng Y, Ji M, Zheng J. Mechanism-based inactivation of cytochrome P450 2D6 by chelidonine. J Biochem Mol Toxicol. 2019;33(2):e22251. PubMed
HEPATOTOXIC DRUGS
2 of 2Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine also falls under HEPATOTOXIC DRUGS.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to focus on with NyQuil: one of its ingredients is acetaminophen (the same medicine as Tylenol), and acetaminophen is famously hard on the liver when you get too much of it. Greater celandine has its own track record of causing liver injury in some people. Stacking the two means you're asking your liver to handle two potential stressors at once, which could raise the odds of harm to it.
To be honest, this concern is based on scattered case reports rather than strong studies, so it's more of a theoretical caution than a proven danger. Still, given that greater celandine is linked to real liver damage and isn't well supported for any use, I'd avoid pairing it with acetaminophen-containing products. Please check with your pharmacist or doctor before combining them.
- Benninger J, Schneider HT, Schuppan D, et al. Acute hepatitis induced by greater celandine (Chelidonium majus). Gastroenterology 1999;117:1234-7. PubMed
- Stickel F, Poschl G, Seitz HK, et al. Acute hepatitis induced by Greater Celandine (Chelidonium majus). Scand J Gastroenterol 2003;38:565-8.
- Moro PA, Cassetti F, Giugliano G, et al. Hepatitis from greater celandine (Chelidonium majus L.): Review of literature and report of a new case. J Ethnopharmacol 2009;124:328-32. PubMed
- Stickel, F., Seitz, H. K., Hahn, E. G., and Schuppan, D. [Liver toxicity of drugs of plant origin]. Z.Gastroenterol. 2001;39(3):225-227.
- Hardeman, E., Van, Overbeke L., Ilegems, S., and Ferrante, M. Acute hepatitis induced by greater celandine (Chelidonium majus). Acta Gastroenterol.Belg. 2008;71(2):281-282.
- Gilca, M., Gaman, L., Panait, E., Stoian, I., and Atanasiu, V. Chelidonium majus--an integrative review: traditional knowledge versus modern findings. Forsch.Komplementmed. 2010;17(5):241-248. PubMed
- Teschke, R., Glass, X., and Schulze, J. Herbal hepatotoxicity by Greater Celandine (Chelidonium majus): causality assessment of 22 spontaneous reports. Regul.Toxicol.Pharmacol. 2011;61(3):282-291. PubMed
- Teschke, R., Glass, X., Schulze, J., and Eickhoff, A. Suspected Greater Celandine hepatotoxicity: liver-specific causality evaluation of published case reports from Europe. Eur.J Gastroenterol.Hepatol. 2012;24(3):270-280. PubMed
- Teschke, R., Frenzel, C., Glass, X., Schulze, J., and Eickhoff, A. Greater Celandine hepatotoxicity: a clinical review. Ann.Hepatol. 2012;11(6):838-848. DOI
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Greater Celandine Also Interacts With Other Medications
Greater Celandine has 624 moderate known drug interactions in our database — the Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Greater Celandine
We haven’t checked that one against Greater Celandine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Greater Celandine. Pick one to open its full report.
See Every Supplement That Interacts With Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine
This page covers Greater Celandine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine page lists 286 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Ephedra (major) and Grapefruit (major).
By severity: 14 major · 227 moderate · 45 minor.
Open the Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interaction page
Taking Greater Celandine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 11 real supplement products containing Greater Celandine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Greater Celandine. Your product may carry other ingredients that interact with Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine too, on top of Greater Celandine — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Greater Celandine and Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#612 of 1,452 supplements looked up here in the last 7 days
#391 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Greater Celandine
What is Greater Celandine?
- Digestive and gallbladder complaints
- Stomach cramps and bloating
- Topical use for warts and skin growths
- Liver and gallbladder 'cleansing'
- Mild pain relief
Greater celandine is a traditional herb most often promoted for digestive and gallbladder complaints, but solid human evidence for any use is lacking. More importantly, it has been linked to serious and sometimes severe liver injury, so most experts advise against taking it by mouth. If you are considering it, talk with your pharmacist or doctor first.
Other Drugs & Greater Celandine
Browse every other medication we’ve checked against Greater Celandine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
624 interactions
- Diclofenac Sodium ›
- Nifedipine ›
- Hydrocortisone ›
- Doxycycline ›
- Minocycline ›
- Propranolol ›
- Tetracycline ›
- Lidocaine ›
- Amoxicillin ›
- Testosterone ›
- Verapamil ›
- Fenofibrate ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Methyltestosterone ›
- Ciprofloxacin ›
- Fentanyl ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Triamcinolone ›
- Allopurinol ›
- Carbamazepine ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Formoterol ›
- Morphine Sulfate ›
- Acetaminophen ›
- Amphetamine ›
- Lofepramine ›
- Methotrexate ›
- Nitrofurantoin ›
- Nortriptyline ›
- Ofloxacin ›
- Propoxyphene ›
- Rifampin ›
- Selegiline ›
- Testosterone Undecanoate ›
- Acarbose ›
- Aripiprazole ›
- Betamethasone ›
- Ciclesonide ›
- Cyclobenzaprine ›
- Dapsone ›
- Desipramine ›
- Doxepin ›
- Doxycycline Hyclate ›
- Duloxetine ›
- Eltrombopag ›
- Fluphenazine ›
- Interferon Alfa-2b ›
- Interferon Beta-1b ›
- Isoniazid ›
- Itraconazole ›
- Levofloxacin ›
Showing 60 of 624 moderate interactions — see all 624 on the Greater Celandine page.
No interaction 2,205 drugs checked — show the list
We also checked Greater Celandine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Ivermectin ›
- Abemaciclib ›
- Sertraline ›
- Losartan Potassium ›
- Aspirin ›
- Escitalopram ›
- Clopidogrel ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Warfarin Sodium ›
- Ibuprofen ›
- Amlodipine Besylate ›
- Docusate ›
- Tadalafil ›
- Valacyclovir ›
- Metformin ›
- Sumatriptan ›
- Hydroxyurea ›
- Semaglutide ›
- Levothyroxine, Liothyronine ›
- Lisinopril ›
- Bupropion ›
- Azithromycin ›
- Pregabalin ›
- Bendamustine ›
- Gabapentin ›
- Lamotrigine ›
- Naproxen ›
- Acyclovir ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
- Candesartan Cilexetil ›
- Acetylsalicylic Acid ›
- Perindopril Arginine, Amlodipine ›
- Amlodipine Besilate ›
- Amlodipine Besylate, Benazepril ›
- Diazepam ›
- Aluminum Hydroxide, Aspirin, Magnesium Hydroxide ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Insulin Degludec, Liraglutide ›
- Aspirin, Caffeine, Orphenadrine ›
- Ezetimibe ›
- Cephalexin ›
- Cyclopentolate ›
- Levetiracetam ›
- Atenolol, Chlorthalidone ›
- Avatrombopag Maleate ›
- Belladonna, Ergotamine, Phenobarbital ›
- Thyroid Hormone ›
- Sacubitril, Valsartan ›
Showing the 60 most looked-up of 2,205 medications checked with no known interaction — see the full Greater Celandine list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine Is Linked to Lower Levels of One Nutrient
Natural Medicines records Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine as a medicine that can lower these. This is not an interaction with Greater Celandine — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Greater Celandine and Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine Together: Common Questions
Can you take Greater Celandine with Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine?
Why are there 2 interactions listed for Greater Celandine and Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine?
How serious is the Greater Celandine and Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.