Heart's Ease + Guselkumab
Guselkumab brand name: Tremfya.
We found no known interaction between Heart's Ease and Guselkumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Heart's Ease and Guselkumab
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Guselkumab and Heart's Ease in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Heart's Ease at all — not against Guselkumab, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Heart's Ease safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Guselkumab
This page covers Heart's Ease only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Guselkumab page lists 53 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Active Hexose Correlated Compound (ahcc) (moderate), Alfalfa (moderate), American Ginseng (moderate), Andrographis (moderate) and Ashwagandha (moderate).
By severity: 52 moderate · 1 minor.
From our pharmacist’s overview on the Guselkumab page
“Guselkumab (Tremfya) quiets an overactive branch of the immune system to control psoriasis and psoriatic arthritis, and all 53 supplements on this list interact the same way, by potentially revving that system back up. None is rated major, 52 are moderate and one is minor, so for most people this reads as a watch list rather than a sto…”
Reviewed by 2 · Jul 18, 2026
Taking Heart's Ease as Part of a Dietary Supplement Product? Check It for Interactions
We hold 35 real supplement products containing Heart's Ease, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Heart's Ease. Even though Heart's Ease itself has no known interaction with Guselkumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Heart's Ease and Guselkumab Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#876 of 1,452 supplements looked up here in the last 7 days
#2,524 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Heart's Ease reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Heart's Ease and Guselkumab records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Heart's Ease
What is Heart's Ease?
- Skin conditions like eczema and cradle cap
- Mild respiratory complaints (cough)
- Mild inflammation
- Diuretic (increasing urine flow)
- General 'blood cleansing' tonic
Heart's Ease (Viola tricolor) is a traditional European herb used mostly for skin problems and mild coughs. Modern human evidence for these uses is very limited, so it should be seen as a gentle traditional remedy rather than a proven treatment. Talk to your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or giving it to a child.
Viola tricolor · Violaceae · Above-ground flowering parts (herb) · Tea, dried herb, tincture, topical preparations, capsules
An interaction check asks whether these two react with each other — it does not ask whether Heart's Ease is a good idea for someone in your situation. Here is what our Heart's Ease record says about it on its own.
Heart's Ease: dosing
There is no well-established, standardized dose for Heart's Ease. Traditional use varies widely depending on whether it is taken as a tea, tincture, or applied to the skin.The safest approach is to follow the directions on the product label and to start with the lowest suggested amount.
From our Heart's Ease monograph — the full record covers uses, side effects and every documented interaction.
About Guselkumab Injection
What Is Guselkumab Injection Used For?
Brand name: Tremfya
Tremfya (guselkumab) injection treats four conditions. For plaque psoriasis and psoriatic arthritis, Tremfya is approved for adults and children 6 years and older who weigh at least 40 kg (about 88 lbs) and who need systemic therapy or phototherapy. For ulcerative colitis and Crohn's disease, Tremfya is approved for adults with moderately to severely active disease.
For ulcerative colitis and Crohn's disease, Tremfya may be given by intravenous (IV) infusion during the initial treatment phase, then switched to subcutaneous (under-the-skin) injections for ongoing maintenance. For plaque psoriasis and psoriatic arthritis, Tremfya is given as subcutaneous injections only.
Most-Reported Side Effects for Guselkumab
From FAERS, the FDA’s public side-effect reporting system (35,559 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Heart's Ease
Browse every other medication we’ve checked against Heart's Ease — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Heart's Ease against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Abemaciclib ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Acetaminophen ›
- Losartan Potassium ›
- Aspirin ›
- Rosuvastatin ›
- Metoprolol ›
- Clopidogrel ›
- Escitalopram ›
- Rivaroxaban ›
- Atorvastatin ›
- Docusate ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Warfarin Sodium ›
- Tadalafil ›
- Valacyclovir ›
- Sumatriptan ›
- Hydroxyurea ›
- Semaglutide ›
- Prednisone ›
- Metformin ›
- Amitriptyline ›
- Propranolol ›
- Lisdexamfetamine ›
- Amoxicillin ›
- Isotretinoin ›
- Methotrexate ›
- Lisinopril ›
- Amlodipine Besylate ›
- Amphetamine ›
- Bendamustine ›
- Bupropion ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Pregabalin ›
- Acyclovir ›
- Lamotrigine ›
- Gabapentin ›
- Dextroamphetamine ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Codeine ›
- Naproxen ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Citalopram ›
- Buspirone ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Heart's Ease list.
Heart's Ease References
The 4 references that drive our Heart's Ease monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Behmanesh Y, Abdollahi M. Hemolysis after consumption of Viola tricolor. WHO Drug Inf (Iran) 2002;16:15-16.
- Klovekorn, W., Tepe, A., and Danesch, U. A randomized, double-blind, vehicle-controlled, half-side comparison with a herbal ointment containing Mahonia aquifolium, Viola tricolor and Centella asiatica for the treatment of mild-to-moderate atopic dermatit
- Kirichenko TV, Sobenin IA, Markina YV, et al. Clinical effectiveness of a combination of black elder berries, violet herb, and calendula flowers in chronic obstructive pulmonary disease: the results of a double-blinded placebo-controlled study. Biology (B PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Heart's Ease and Guselkumab Together: Common Questions
Is it safe to take Heart's Ease with Guselkumab?
Does Guselkumab interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.