Medication interaction hub

What Supplements Interact with Guselkumab?

Guselkumab brand name: Tremfya. Every interaction below applies to the brands too.

53 Interactions 52 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated September 25, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Guselkumab? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Guselkumab against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Guselkumab (Tremfya) quiets an overactive branch of the immune system to control psoriasis and psoriatic arthritis, and all 53 supplements on this list interact the same way, by potentially revving that system back up. None is rated major, 52 are moderate and one is minor, so for most people this reads as a watch list rather than a stop sign. The stake here is effectiveness more than danger: immune boosters like echinacea and astragalus could, in theory, blunt what the drug is doing for your skin and joints.

Nearly every entry rests on lab or animal research rather than confirmed problems in patients, which helps explain why nothing rises above moderate. Still, a product sold to strengthen immunity is, by design, pulling against a medicine built to calm it. If plaques or joint pain return after starting one of these, that flare is your cue to reassess the pairing.

— , Clinical Pharmacist · July 18, 2026

Moderate 52 Minor 1 No known interaction 1,399

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Guselkumab: Top Interactions at a Glance

The most significant Guselkumab supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 53 interacting ingredients — plus 1,399 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Guselkumab + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Possible Active Hexose Correlated Compound (ahcc) + Guselkumabi

Theoretically, taking AHCC might decrease the effects of immunosuppressant drugs.

Read the full interaction Moderate Likelihood Possible Alfalfa + Guselkumabi

Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.

Read the full interaction Moderate Likelihood Possible American Ginseng + Guselkumabi

Theoretically, American ginseng use might interfere with immunosuppressive therapy.

Read the full interaction Moderate Likelihood Possible Andrographis + Guselkumabi

Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Guselkumabi

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.

Read the full interaction Moderate Likelihood Possible Astragalus + Guselkumabi

Theoretically, astragalus might interfere with immunosuppressive therapy.

Read the full interaction
The complete list

Every Supplement Checked Against Guselkumab

All 1,452 ingredients in our database, ranked by severity — 53 with a Guselkumab interaction on file and 1,399 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Guselkumab?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ashwagandha with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.

Full Ashwagandha + Guselkumab answer

Can you take Rhodiola with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola use might interfere with immunosuppressive therapy.

Full Rhodiola + Guselkumab answer

Can you take Panax Ginseng with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng use might interfere with immunosuppressive therapy.

Full Panax Ginseng + Guselkumab answer

Can you take Rice Bran Arabinoxylan Compound with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Full Rice Bran Arabinoxylan Compound + Guselkumab answer

Can you take Selenium with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.

Full Selenium + Guselkumab answer

Can you take Shark Cartilage with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, shark cartilage might interfere with immunosuppressive therapy.

Full Shark Cartilage + Guselkumab answer

Can you take Shiitake Mushroom with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.

Full Shiitake Mushroom + Guselkumab answer

Can you take Thuja with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja might stimulate immune function.

Full Thuja + Guselkumab answer

Can you take Thunder God Vine with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might enhance the effects of immunosuppressant drugs.

Full Thunder God Vine + Guselkumab answer

Can you take Thymus Extract with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, patients taking immunosuppressants may be at an increased risk of infection from contaminated thymus extract.

Full Thymus Extract + Guselkumab answer

Can you take Tinospora Cordifolia with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might reduce the effectiveness of immunosuppressants.

Full Tinospora Cordifolia + Guselkumab answer

Can you take Trichopus Zeylanicus with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Trichopus zeylanicus might reduce the effects of immunosuppressants.

Full Trichopus Zeylanicus + Guselkumab answer

Can you take Umckaloabo with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Pelargonium sidoides might decrease the effectiveness of immunosuppressant therapy.

Full Umckaloabo + Guselkumab answer

Can you take Lychee with Guselkumab?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, lychee might reduce the effectiveness of immunosuppressant drugs.

Full Lychee + Guselkumab answer

Can you take Active Hexose Correlated Compound (ahcc) with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking AHCC might decrease the effects of immunosuppressant drugs.

Full Active Hexose Correlated Compound (ahcc) + Guselkumab answer

Can you take Alfalfa with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.

Full Alfalfa + Guselkumab answer

Can you take American Ginseng with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, American ginseng use might interfere with immunosuppressive therapy.

Full American Ginseng + Guselkumab answer

Can you take Andrographis with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.

Full Andrographis + Guselkumab answer

Can you take Astragalus with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astragalus might interfere with immunosuppressive therapy.

Full Astragalus + Guselkumab answer

Can you take Bee Venom with Guselkumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bee venom might stimulate immune system activity.Theoretically, bee venom might interfere with immunosuppressant therapy.

Full Bee Venom + Guselkumab answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Guselkumab is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Guselkumab, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Guselkumab sits in 1 interaction category. Open any one to see what the group means:

Immunosuppressants 53 ingredients

Medications that damp down the immune system. Supplements that stimulate immunity can work against them.

53 of the supplement ingredients on this page reach Guselkumab through this category.

About Guselkumab

Guselkumab is an injectable biologic medication used to treat moderate-to-severe plaque psoriasis, active psoriatic arthritis, moderately to severely active ulcerative colitis, and moderately to severely active Crohn's disease.

Generic name: Guselkumab  ·  Brand name: Tremfya.

See the full Guselkumab Injection drug information
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Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Guselkumab.

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Pharmacist Counseling Corner

Guselkumab & Supplements: Common Questions

What supplements interact with Guselkumab?
More than you might expect — 53 in total, though they are far from equal: 0 are rated major, 52 moderate, and 1 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Active Hexose Correlated Compound (ahcc), Alfalfa, American Ginseng.
Which Guselkumab supplement interactions are the most serious?
None of the Guselkumab supplement interactions on file are currently rated major. The most significant are the 52 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Guselkumab?
Usually yes — most people on Guselkumab can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Tremfya have the same supplement interactions as Guselkumab?
Yes — Tremfya all contain Guselkumab, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Guselkumab and my other medications?
This page covers Guselkumab against supplements and herbal ingredients. Checking Guselkumab against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Guselkumab Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 25, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.