Heart's Ease + Lonafarnib
Lonafarnib brand name: Zokinvy.
We found no known interaction between Heart's Ease and Lonafarnib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Lonafarnib states a food rule worth keeping to.
Heart's Ease and Lonafarnib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Lonafarnib and Heart's Ease in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Heart's Ease at all — not against Lonafarnib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Heart's Ease safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Lonafarnib Products Have a Food Rule — Heart's Ease Should Not Break It
At least one FDA label for a product containing Lonafarnib says to take it with food. If you take Heart's Ease on an empty stomach out of habit, keep them separate — and take Lonafarnib with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Lonafarnib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
If a dose is missed, take the dose as soon as possible with food, up to 8 hours prior to the next scheduled dose.
From the Dosage and Administration section of the FDA label we read for Lonafarnib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Lonafarnib
This page covers Heart's Ease only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lonafarnib page lists 160 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).
By severity: 5 major · 115 moderate · 40 minor.
From our pharmacist’s overview on the Lonafarnib page
“If you or your child takes lonafarnib (Zokinvy) for progeria, treat supplements with real caution. Most of the 160 flagged ingredients cross paths with the CYP3A4 enzyme, the same one that handles lonafarnib, so the traffic runs both ways.”
Reviewed by 2 · Jul 18, 2026
Taking Heart's Ease as Part of a Dietary Supplement Product? Check It for Interactions
We hold 35 real supplement products containing Heart's Ease, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Heart's Ease. Even though Heart's Ease itself has no known interaction with Lonafarnib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Heart's Ease and Lonafarnib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#785 of 1,452 supplements looked up here in the last 7 days
#1,546 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Heart's Ease reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Heart's Ease and Lonafarnib records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Heart's Ease
What is Heart's Ease?
- Skin conditions like eczema and cradle cap
- Mild respiratory complaints (cough)
- Mild inflammation
- Diuretic (increasing urine flow)
- General 'blood cleansing' tonic
Heart's Ease (Viola tricolor) is a traditional European herb used mostly for skin problems and mild coughs. Modern human evidence for these uses is very limited, so it should be seen as a gentle traditional remedy rather than a proven treatment. Talk to your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or giving it to a child.
Viola tricolor · Violaceae · Above-ground flowering parts (herb) · Tea, dried herb, tincture, topical preparations, capsules
An interaction check asks whether these two react with each other — it does not ask whether Heart's Ease is a good idea for someone in your situation. Here is what our Heart's Ease record says about it on its own.
Heart's Ease: dosing
There is no well-established, standardized dose for Heart's Ease. Traditional use varies widely depending on whether it is taken as a tea, tincture, or applied to the skin.The safest approach is to follow the directions on the product label and to start with the lowest suggested amount.
From our Heart's Ease monograph — the full record covers uses, side effects and every documented interaction.
About Lonafarnib
What Is Lonafarnib Used For?
Brand name: Zokinvy
Zokinvy (lonafarnib) is approved for patients 12 months of age and older who have a body surface area of 0.39 m² or above. It is used to reduce the risk of mortality in Hutchinson-Gilford Progeria Syndrome (HGPS) — a rare, severe premature-aging disorder.
Zokinvy is also used to treat processing-deficient Progeroid Laminopathies — a related group of rare genetic conditions — specifically those caused by a heterozygous LMNA mutation with progerin-like protein buildup, or by homozygous or compound heterozygous ZMPSTE24 mutations. It is not indicated for other Progeroid Syndromes or processing-proficient Progeroid Laminopathies.
Most-Reported Side Effects for Lonafarnib
From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Heart's Ease
Browse every other medication we’ve checked against Heart's Ease — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Heart's Ease against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Metoprolol ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Heart's Ease list.
Heart's Ease References
The 4 references that drive our Heart's Ease monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Behmanesh Y, Abdollahi M. Hemolysis after consumption of Viola tricolor. WHO Drug Inf (Iran) 2002;16:15-16.
- Klovekorn, W., Tepe, A., and Danesch, U. A randomized, double-blind, vehicle-controlled, half-side comparison with a herbal ointment containing Mahonia aquifolium, Viola tricolor and Centella asiatica for the treatment of mild-to-moderate atopic dermatit
- Kirichenko TV, Sobenin IA, Markina YV, et al. Clinical effectiveness of a combination of black elder berries, violet herb, and calendula flowers in chronic obstructive pulmonary disease: the results of a double-blinded placebo-controlled study. Biology (B PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Heart's Ease and Lonafarnib Together: Common Questions
Is it safe to take Heart's Ease with Lonafarnib?
Should I take Heart's Ease and Lonafarnib at the same time of day?
Does Lonafarnib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.