Drug & supplement interaction

Indian Cassia + Fruquintinib

Fruquintinib brand name: Fruzaqla.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Indian Cassia and Fruquintinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Indian Cassia and Fruquintinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fruquintinib and Indian Cassia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Indian Cassia safety at a glance

Indian Cassia overall Use caution Generally safe as a food spice, but concentrated supplements and oils are not well studied.
Pregnancy Use caution Food amounts are likely fine, but avoid medicinal or concentrated doses without medical advice.
Breastfeeding Use caution Food amounts are likely fine, but safety of concentrated forms is unknown.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fruquintinib and Indian Cassia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Fruquintinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Fruquintinib is filed under 3 classifications — hepatotoxic drugs, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Indian Cassia has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and diuretic drugs (moderate) — and none of Fruquintinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Indian Cassia Does Interact With Other Medications

Indian Cassia has 161 moderate known drug interactions in our database — Fruquintinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 161 No known interaction 2,669 (incl. Fruquintinib)
Taking anything else?

Check Another of Your Medications Against Indian Cassia

Covers the 2,830 medications we’ve checked against Indian Cassia. Pick one to open its full report.

What to actually watch for

What Fruquintinib’s Own FDA Label Lists

This is not an interaction — none of it involves Indian Cassia. These are the most notable effects listed in the ADVERSE REACTIONS section of Fruquintinib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • A change in thyroid levels Worth acting on
  • Kidney problems Worth acting on
  • Raised blood pressure Worth acting on
  • Liver problems Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on
  • Mouth irritation or sores
  • Joint pain
  • Muscle pain
  • Stomach pain

Showing the 10 most notable of 13 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Fruquintinib. Read the label on DailyMed › Indian Cassia’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Indian Cassia side to compare — that is a limit of the record, not a statement that Indian Cassia has no side effects.

Everything else you take

See Every Supplement That Interacts With Fruquintinib

This page covers Indian Cassia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fruquintinib page lists 168 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 124 moderate · 38 minor.

From our pharmacist’s overview on the Fruquintinib page

“Fruquintinib (Fruzaqla) is an oral targeted therapy for advanced colorectal cancer, which means keeping its blood level steady is part of what makes it work, and I would treat this supplement list with genuine care. Of the 168 ingredients on file, the large majority interact through CYP3A4, the liver enzyme that clears the drug, so the…”

Reviewed by 2 · Jul 18, 2026

Open the Fruquintinib interaction page

One more smart check

Taking Indian Cassia as Part of a Dietary Supplement Product? Check It for Interactions

We hold 31 real supplement products containing Indian Cassia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Indian Cassia. Even though Indian Cassia itself has no known interaction with Fruquintinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Indian Cassia and Fruquintinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Indian Cassia
Steady interest

#1,011 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fruquintinib
Steady interest

#2,220 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Indian Cassia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Indian Cassia and Fruquintinib records this page draws on were last updated July 3, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Indian Cassia

What is Indian Cassia?

  • Flavoring food
  • Digestive upset
  • Blood sugar support
  • Cold and cough relief
  • Antimicrobial

Indian Cassia (Cinnamomum tamala), also known as Indian bay leaf or tejpat, is an aromatic leaf used widely as a cooking spice and in traditional medicine across South Asia. Human evidence for its health benefits is very limited, so it is best enjoyed as a culinary spice rather than relied on to treat any condition. Used as food it is generally well tolerated, but talk to your pharmacist or doctor before using concentrated supplements or oils.

Cinnamomum tamala · Lauraceae · Leaves (often called tejpat or Indian bay leaf) and bark · Whole dried leaves used in cooking, powder, tea, and essential oil

An interaction check asks whether these two react with each other — it does not ask whether Indian Cassia is a good idea for someone in your situation. Here is what our Indian Cassia record says about it on its own.

Indian Cassia: dosing

There is no established standardized medicinal dose for Indian Cassia. As a spice, people use small amounts of the dried leaf to flavor cooking, which is the most common and best-understood use.For capsules, powders, teas, or oils, follow the directions on the product label, since strength varies between products.

From our Indian Cassia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Indian Cassia monograph & all interactions
Medication

About Fruquintinib

What Is Fruquintinib Used For?

Brand name: Fruzaqla

Fruzaqla (fruquintinib) is used to treat adults with metastatic colorectal cancer (mCRC) — colorectal cancer that has spread to other parts of the body. It is specifically for patients who have already been treated with several standard chemotherapy regimens and other targeted therapies.

Fruzaqla is intended for patients who have previously received fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and — if their tumor is RAS wild-type and it is medically appropriate — an anti-EGFR therapy.

Most-Reported Side Effects for Fruquintinib

From FAERS, the FDA’s public side-effect reporting system (3,770 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 470 reports
Colorectal cancer metastatic 388 reports
Colon cancer 371 reports
Diarrhea 275 reports
Blood pressure increased 269 reports
See full Fruquintinib drug information
Keep checking

Other Drugs & Indian Cassia

Browse every other medication we’ve checked against Indian Cassia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
161Moderate
0Minor
2,668No known interaction
161 Moderate 2,668 No interaction
Moderate

161 interactions

Showing 60 of 161 moderate interactions — see all 161 on the Indian Cassia page.

No interaction 2,668 drugs checked — show the list

We also checked Indian Cassia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,668 medications checked with no known interaction — see the full Indian Cassia list.

See the full Indian Cassia interactions page
See every supplement checked against Fruquintinib, ranked by severity
Evidence & sources

Indian Cassia References

The 3 references that drive our Indian Cassia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Singh TN, Upadhyay BN, Tewari CM, Tripathi SN. Management of diabetes mellitus (prameha) with inula racemosa and cinnamomum tamala. Anc Sci Life. 1985 Jul;5(1):9-16.
  2. Rahman M, Khatun A, Islam MM, et al. Evaluation of antimicrobial, cytotoxic, thrombolytic, diuretic properties and total phenolic content of Cinnamomum tamala. International Journal of Green Pharmacy. 2013 Jul 1;7(3):236. DOI
  3. Konda MR, Alluri KV, Janardhanan PK, Trimurtulu G, Sengupta K. Combined extracts of Garcinia mangostana fruit rind and Cinnamomum tamala leaf supplementation enhances muscle strength and endurance in resistance trained males. J Int Soc Sports Nutr 2018;15

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Indian Cassia and Fruquintinib Together: Common Questions

Is it safe to take Indian Cassia with Fruquintinib?
We do not list a known interaction between Indian Cassia and Fruquintinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Indian Cassia and Fruquintinib combination checked?
Interactions in our licensed database are recorded against drug classes. Fruquintinib is filed under 3 classifications, and Indian Cassia has documented interactions with 2 drug classes — none of Fruquintinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Indian Cassia interact with any other medications?
Yes. Indian Cassia has 161 documented drug interactions in our database — Fruquintinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Fruquintinib interact with any supplements?
Yes. Fruquintinib has documented interactions with 168 supplements in our database — Indian Cassia is not one of them. The Fruquintinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Indian Cassia monograph Uses, safety profile, and every drug interaction in one place Fruquintinib drug information The full plain-English guide to this medication Fruquintinib supplement interactions Every supplement checked against Fruquintinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fruquintinib and Indian Cassia?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.