Drug & supplement interaction

Japanese Apricot + Tobramycin

Tobramycin brand names: Nebcin, Tobi Podhaler, Bethkis, Kitabis PAK.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Japanese Apricot and Tobramycin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Japanese Apricot and Tobramycin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tobramycin and Japanese Apricot in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Japanese Apricot safety at a glance

Japanese Apricot overall Use caution Generally considered safe as a food, but concentrated supplement evidence is limited and quality varies.
Pregnancy Use caution Food amounts are likely fine, but concentrated extracts have not been well studied; use caution and ask your doctor.
Breastfeeding Use caution Little safety data exists for supplement-strength products, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tobramycin and Japanese Apricot? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tobramycin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tobramycin is filed under 4 classifications — including aminoglycoside antibiotics, antibiotic drugs, nephrotoxic drugs. Japanese Apricot has documented interactions with 2 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate) and antidiabetes drugs (moderate) — and none of Tobramycin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Japanese Apricot Does Interact With Other Medications

Japanese Apricot has 208 moderate known drug interactions in our database — Tobramycin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 208 No known interaction 2,622 (incl. Tobramycin)
Taking anything else?

Check Another of Your Medications Against Japanese Apricot

Covers the 2,830 medications we’ve checked against Japanese Apricot. Pick one to open its full report.

What to actually watch for

What Japanese Apricot Itself Has Been Linked To

This is not an interaction — nothing below involves Tobramycin. It is the side-effect record for Japanese Apricot on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Japanese Apricot, this list is the first place to look.

  • Constipation Additional detail

    “Orally, Japanese apricot dried fruit extract seems to be well tolerated. Side effects reported in clinical research include gastric intolerance. Diluted Japanese apricot juice concentrate may cause constipation. Allergies to Japanese apricot are rare. The raw fruit of Japanese apricot is thought to be toxic due to the cyanogenic glycosides prunasin and amygdalin.”

    Japanese Apricot · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    4 sources cited
    1. 100027. Beretta A, Accinni R, Dellanoce C, Tonini A, Cardot JM, Bussiére A. Efficacy of a standardized extract of Prunus mume in liver protection and redox homeostasis: A randomized, double-blind, placebo-controlled study. Phytother Res. 2016;30(6):949-55.
    2. 100029. Nakajima S, Fujita K, Inoue Y, Nishio M, Seto Y. Effect of the folk remedy, Bainiku-ekisu, a concentrate of Prunus mume juice, on Helicobacter pylori infection in humans. Helicobacter. 2006;11(6):589-91.
    3. 100028. Iijima S, Ito M, Makabe K, Murakami Y, Yokooji T, Matsuo H. Case of food-dependent exercise-induced anaphylaxis due to Japanese apricot and peach: Detection of causative antigens. J Dermatol. 2015;42(9):916-7. PubMed
    4. 13198. Chuda Y, Ono H, Ohnishi-Kameyama M, et al. Mumefural, citric acid derivative improving blood fluidity from fruit-juice concentrate of Japanese apricot (Prunus mume Sieb. et Zucc).J Agric Food Chem 1999;47:828-31. .

    “Orally, Japanese apricot dried fruit extract 300 mg daily has been reported to cause gastric intolerance in one patient in one clinical study. In other clinical research, dilute Japanese apricot juice concentrate has been reported to cause constipation in one patient.”

    Japanese Apricot · Natural Medicines adverse-effect record, reported in constipation.

    2 sources cited
    1. 100027. Beretta A, Accinni R, Dellanoce C, Tonini A, Cardot JM, Bussiére A. Efficacy of a standardized extract of Prunus mume in liver protection and redox homeostasis: A randomized, double-blind, placebo-controlled study. Phytother Res. 2016;30(6):949-55.
    2. 100029. Nakajima S, Fujita K, Inoue Y, Nishio M, Seto Y. Effect of the folk remedy, Bainiku-ekisu, a concentrate of Prunus mume juice, on Helicobacter pylori infection in humans. Helicobacter. 2006;11(6):589-91.

Everything above comes from the Natural Medicines adverse-effect record for Japanese Apricot — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Tobramycin’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Tobramycin column appears here.

Everything else you take

See Every Supplement That Interacts With Tobramycin

This page covers Japanese Apricot only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tobramycin page lists 52 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), Aristolochia (moderate) and Bacillus Coagulans (moderate).

By severity: 3 major · 38 moderate · 11 minor.

From our pharmacist’s overview on the Tobramycin page

“Kidney protection is the first thing to understand with tobramycin (Nebcin, Tobi Podhaler, Bethkis, Kitabis PAK), an aminoglycoside antibiotic that can stress the kidneys even on its own, so this list warrants genuine care rather than a quick glance. The worst pairings, Siberian cocklebur and asarabacca, can injure the kidneys themselv…”

Reviewed by 2 · Jul 18, 2026

Open the Tobramycin interaction page

One more smart check

Taking Japanese Apricot as Part of a Dietary Supplement Product? Check It for Interactions

We hold 12 real supplement products containing Japanese Apricot, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Japanese Apricot. Even though Japanese Apricot itself has no known interaction with Tobramycin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Japanese Apricot and Tobramycin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Japanese Apricot
Steady interest

#925 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tobramycin
Steady interest

#2,364 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Japanese Apricot reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Japanese Apricot and Tobramycin records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Japanese Apricot

What is Japanese Apricot?

  • Digestive upset
  • Fatigue and general wellness
  • Sore throat and cough
  • Antimicrobial support
  • Liver and detox support (traditional)

Japanese Apricot (Prunus mume) is a tart fruit used widely in East Asian foods and traditional medicine, often as pickled umeboshi or a concentrated extract. It has a long history of culinary and folk use, but high-quality human studies are limited, so most health claims remain unproven. The processed fruit is generally well tolerated as a food, but talk to a pharmacist or doctor before using concentrated supplements.

Prunus mume · Rosaceae · Fruit (often unripe, smoked, or processed into extracts) · Pickled fruit (umeboshi), concentrated fruit extract, paste, juice, syrup, capsules, tea

An interaction check asks whether these two react with each other — it does not ask whether Japanese Apricot is a good idea for someone in your situation. Here is what our Japanese Apricot record says about it on its own.

Japanese Apricot: dosing

There is no well-established standard dose for Japanese Apricot supplements. The amount varies widely depending on the form, whether it is a food (like umeboshi), a syrup, a paste, or a concentrated extract.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Japanese Apricot monograph — the full record covers uses, side effects and every documented interaction.

Read the full Japanese Apricot monograph & all interactions
Medication

About Tobramycin Injection

What Is Tobramycin Injection Used For?

Brand names: Nebcin, Tobi Podhaler, Bethkis, Kitabis PAK

Tobramycin Injection is used to treat serious and life-threatening bacterial infections caused by susceptible bacteria. It is approved for adults and children for infections of the blood (septicemia), lungs and airways, brain and spinal cord (meningitis), abdomen, skin, bones, and urinary tract.

Because antibiotic resistance is a growing concern, Tobramycin Injection should only be used when there is a proven or strongly suspected bacterial infection. Your care team will use culture and lab results to confirm it is the right choice.

See full Tobramycin Injection drug information
Keep checking

Other Drugs & Japanese Apricot

Browse every other medication we’ve checked against Japanese Apricot — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
208Moderate
0Minor
2,621No known interaction
208 Moderate 2,621 No interaction
Moderate

208 interactions

Showing 60 of 208 moderate interactions — see all 208 on the Japanese Apricot page.

No interaction 2,621 drugs checked — show the list

We also checked Japanese Apricot against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,621 medications checked with no known interaction — see the full Japanese Apricot list.

See the full Japanese Apricot interactions page
See every supplement checked against Tobramycin, ranked by severity
Evidence & sources

Japanese Apricot References

The 10 references that drive our Japanese Apricot monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chuda Y, Ono H, Ohnishi-Kameyama M, et al. Mumefural, citric acid derivative improving blood fluidity from fruit-juice concentrate of Japanese apricot (Prunus mume Sieb. et Zucc).J Agric Food Chem 1999;47:828-31. .
  2. Matsuda H, Morikawa T, Ishiwada T, et al. Medicinal flowers. VIII. Radical scavenging constituents from the flowers of Prunus mume: structure of prunose III. Chem Pharm Bull (Tokyo) 2003;51:440-3.. PubMed
  3. Maekita T, Kato J, Enomoto S, et al. Japanese apricot improves symptoms of gastrointestinal dysmotility associated with gastroesophageal reflux disease. World J Gastroenterol. 2015;21(26):8170-7. PubMed
  4. Takemura S, Yoshimasu K, Fukumoto J, et al. Safety and adherence of Umezu polyphenols in the Japanese plum (Prunus mume) in a 12-week double-blind randomized placebo-controlled pilot trial to evaluate antihypertensive effects. Environ Health Prev Med. 2 PubMed
  5. Shin EJ, Hur HJ, Sung MJ, et al. Ethanol extract of the Prunus mume fruits stimulates glucose uptake by regulating PPAR-γ in C2C12 myotubes and ameliorates glucose intolerance and fat accumulation in mice fed a high-fat diet. Food Chem. 2013;141(4):
  6. Hokari A, Ishikawa T, Tajiri H, et al. Efficacy of MK615 for the treatment of patients with liver disorders. World J Gastroenterol. 2012;18(31):4118-26. PubMed
  7. Enomoto S, Yanaoka K, Utsunomiya H, et al. Inhibitory effects of Japanese apricot (Prunus mume Siebold et Zucc.; Ume) on Helicobacter pylori-related chronic gastritis. Eur J Clin Nutr. 2010;64(7):714-9. PubMed
  8. Beretta A, Accinni R, Dellanoce C, Tonini A, Cardot JM, Bussiére A. Efficacy of a standardized extract of Prunus mume in liver protection and redox homeostasis: A randomized, double-blind, placebo-controlled study. Phytother Res. 2016;30(6):949-55.
  9. Iijima S, Ito M, Makabe K, Murakami Y, Yokooji T, Matsuo H. Case of food-dependent exercise-induced anaphylaxis due to Japanese apricot and peach: Detection of causative antigens. J Dermatol. 2015;42(9):916-7. PubMed
  10. Nakajima S, Fujita K, Inoue Y, Nishio M, Seto Y. Effect of the folk remedy, Bainiku-ekisu, a concentrate of Prunus mume juice, on Helicobacter pylori infection in humans. Helicobacter. 2006;11(6):589-91.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Japanese Apricot and Tobramycin Together: Common Questions

Is it safe to take Japanese Apricot with Tobramycin?
We do not list a known interaction between Japanese Apricot and Tobramycin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Japanese Apricot and Tobramycin combination checked?
Interactions in our licensed database are recorded against drug classes. Tobramycin is filed under 4 classifications, and Japanese Apricot has documented interactions with 2 drug classes — none of Tobramycin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Japanese Apricot interact with any other medications?
Yes. Japanese Apricot has 208 documented drug interactions in our database — Tobramycin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tobramycin interact with any supplements?
Yes. Tobramycin has documented interactions with 52 supplements in our database — Japanese Apricot is not one of them. The Tobramycin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Japanese Apricot monograph Uses, safety profile, and every drug interaction in one place Tobramycin Injection drug information The full plain-English guide to this medication Tobramycin supplement interactions Every supplement checked against Tobramycin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tobramycin and Japanese Apricot?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.