Drug & supplement interaction

Java Tea + Diphenhydramine Hydrochloride, Naproxen Sodium

Diphenhydramine Hydrochloride, Naproxen Sodium brand name: Aleve PM.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Java Tea and Diphenhydramine Hydrochloride, Naproxen Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Diphenhydramine Hydrochloride, Naproxen Sodium states a food rule worth keeping to.

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Interaction report

Java Tea and Diphenhydramine Hydrochloride, Naproxen Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diphenhydramine Hydrochloride, Naproxen Sodium and Java Tea in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Java Tea safety at a glance

Java Tea overall Use caution Generally considered well tolerated short-term, but human safety data are limited.
Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid Not enough safety data, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diphenhydramine Hydrochloride, Naproxen Sodium and Java Tea? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Diphenhydramine Hydrochloride, Naproxen Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Diphenhydramine Hydrochloride, Naproxen Sodium is filed under 14 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), cytochrome p450 2c9 (cyp2c9) substrates, anticoagulant/antiplatelet drugs. Java Tea has documented interactions with 2 drug classes — the most serious being antihypertensive drugs (moderate) and lithium (moderate) — and none of Diphenhydramine Hydrochloride, Naproxen Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Java Tea Does Interact With Other Medications

Java Tea has 173 moderate known drug interactions in our database — Diphenhydramine Hydrochloride, Naproxen Sodium isn’t one of them. If you take anything else, check it against the full list below.

Moderate 173 No known interaction 2,657 (incl. Diphenhydramine Hydrochloride, Naproxen Sodium)
Taking anything else?

Check Another of Your Medications Against Java Tea

Covers the 2,830 medications we’ve checked against Java Tea. Pick one to open its full report.

How to take them

Some Diphenhydramine Hydrochloride, Naproxen Sodium Products Have a Food Rule — Java Tea Should Not Break It

At least one FDA label for a product containing Diphenhydramine Hydrochloride, Naproxen Sodium says to take it with food. If you take Java Tea on an empty stomach out of habit, keep them separate — and take Diphenhydramine Hydrochloride, Naproxen Sodium with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Diphenhydramine Hydrochloride, Naproxen Sodium products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Directions • do not take more than directed • drink a full glass of water with each dose • adults and children 12 years and over: take 2 caplets at bedtime • do not take more than 2 caplets in 24 hours • if taken with food, this product may take longer to work

From the Dosage and Administration section of the FDA label we read for Diphenhydramine Hydrochloride, Naproxen Sodium — where that label names a specific product, the instruction is that product's.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Diphenhydramine Hydrochloride, Naproxen Sodium

This page covers Java Tea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diphenhydramine Hydrochloride, Naproxen Sodium page lists 378 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 13 major · 320 moderate · 45 minor.

From our pharmacist’s overview on the Diphenhydramine Hydrochloride, Naproxen Sodium page

“Aleve PM combines naproxen, an NSAID, with the sedating antihistamine diphenhydramine, and its supplement list earns genuine care rather than a quick skim. Thirteen of the 378 ingredients on file rate major, and the two largest themes track the pill's two halves.”

Reviewed by 2 · Jul 18, 2026

Open the Diphenhydramine Hydrochloride, Naproxen Sodium interaction page

One more smart check

Taking Java Tea as Part of a Dietary Supplement Product? Check It for Interactions

We hold 64 real supplement products containing Java Tea, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Java Tea. Even though Java Tea itself has no known interaction with Diphenhydramine Hydrochloride, Naproxen Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Java Tea and Diphenhydramine Hydrochloride, Naproxen Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Java Tea
Steady interest

#1,129 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diphenhydramine Hydrochloride, Naproxen Sodium
Steady interest

#1,862 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Java Tea reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Java Tea and Diphenhydramine Hydrochloride, Naproxen Sodium records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Java Tea

What is Java Tea?

  • Urinary tract health
  • Mild fluid retention
  • Kidney and bladder support
  • Mild diuretic ('water pill') effect
  • Digestive complaints

Java Tea is a Southeast Asian herb traditionally used as a gentle diuretic and for urinary tract and kidney support. Some early lab, animal, and small human studies are encouraging, but high-quality evidence in people is limited, so it should not replace proven treatments. Talk to a pharmacist or doctor before using it, especially if you have kidney problems or take other medicines.

Orthosiphon stamineus · Lamiaceae · Leaves and stems (aerial parts) · Tea, dried herb, capsules, liquid extracts, tinctures

An interaction check asks whether these two react with each other — it does not ask whether Java Tea is a good idea for someone in your situation. Here is what our Java Tea record says about it on its own.

Java Tea: dosing

There is no well-established standardized dose for Java Tea. The right amount can vary depending on the form (tea, capsule, or extract) and the strength of the product.The safest approach is to follow the directions on the product label and not exceed the recommended amount. Because Java Tea has a diuretic effect, it is also wise to stay well hydrated.

From our Java Tea monograph — the full record covers uses, side effects and every documented interaction.

Read the full Java Tea monograph & all interactions
Keep checking

Other Drugs & Java Tea

Browse every other medication we’ve checked against Java Tea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
173Moderate
0Minor
2,656No known interaction
173 Moderate 2,656 No interaction
Moderate

173 interactions

Showing 60 of 173 moderate interactions — see all 173 on the Java Tea page.

No interaction 2,656 drugs checked — show the list

We also checked Java Tea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,656 medications checked with no known interaction — see the full Java Tea list.

See the full Java Tea interactions page
See every supplement checked against Diphenhydramine Hydrochloride, Naproxen Sodium, ranked by severity
Evidence & sources

Java Tea References

The 2 references that drive our Java Tea monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Cicero AF, De Sando V, Izzo R, Vasta A, Trimarco A, Borghi C. Effect of a combined nutraceutical containing Orthosiphon stamineus effect on blood pressure and metabolic syndrome components in hypertensive dyslipidaemic patients: a randomized clinical tria
  2. Vahlensieck W, Lorenz H, Schumacher-Stimpfl A, Fischer R, Naber KG. Effect of a herbal therapy on clinical symptoms of acute lower uncomplicated urinary tract infections in women: Secondary analysis from a randomized controlled trial. Antibiotics (Basel). PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Java Tea and Diphenhydramine Hydrochloride, Naproxen Sodium Together: Common Questions

Is it safe to take Java Tea with Diphenhydramine Hydrochloride, Naproxen Sodium?
We do not list a known interaction between Java Tea and Diphenhydramine Hydrochloride, Naproxen Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Java Tea and Diphenhydramine Hydrochloride, Naproxen Sodium at the same time of day?
At least one FDA label for a product containing Diphenhydramine Hydrochloride, Naproxen Sodium says to take it with food. If you take Java Tea on an empty stomach out of habit, keep them separate and take Diphenhydramine Hydrochloride, Naproxen Sodium with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Diphenhydramine Hydrochloride, Naproxen Sodium products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Java Tea and Diphenhydramine Hydrochloride, Naproxen Sodium combination checked?
Interactions in our licensed database are recorded against drug classes. Diphenhydramine Hydrochloride, Naproxen Sodium is filed under 14 classifications, and Java Tea has documented interactions with 2 drug classes — none of Diphenhydramine Hydrochloride, Naproxen Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Java Tea interact with any other medications?
Yes. Java Tea has 173 documented drug interactions in our database — Diphenhydramine Hydrochloride, Naproxen Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Diphenhydramine Hydrochloride, Naproxen Sodium interact with any supplements?
Yes. Diphenhydramine Hydrochloride, Naproxen Sodium has documented interactions with 378 supplements in our database — Java Tea is not one of them. The Diphenhydramine Hydrochloride, Naproxen Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Java Tea monograph Uses, safety profile, and every drug interaction in one place Diphenhydramine Hydrochloride, Naproxen Sodium supplement interactions Every supplement checked against Diphenhydramine Hydrochloride, Naproxen Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diphenhydramine Hydrochloride, Naproxen Sodium and Java Tea?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.