Drug & supplement interaction

Kousso + Insulin Glargine

Insulin Glargine brand names: Basaglar, Lusduna, Semglee.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Kousso has a moderate interaction with Insulin Glargine. Theoretically, kousso might have an additive effect with antidiabetes drugs and cause hypoglycemia.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Kousso and Insulin Glargine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Insulin Glargine

Insulin Glargine falls under ANTIDIABETES DRUGS — the group Kousso interacts with.

Theoretically, kousso might have an additive effect with antidiabetes drugs and cause hypoglycemia. Animal research shows that kousso flower extract modestly decreases blood glucose levels in diabetic mice.
Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: insulin glargine is your steady, long-acting basal insulin, and its whole job is to lower blood sugar. Kousso, an old worm remedy, appears to nudge blood sugar down on its own (at least in diabetic mice). Stack those two together and the worry is that they could add up, pushing your sugar too low. That would look like the usual low-sugar warning signs with insulin: shakiness, sweating, a fast heartbeat, confusion, or feeling lightheaded.

One important caveat: this is only a theory based on animal research, not real human studies, so I wouldn't lose sleep over it. Still, since lows can be dangerous, please loop in your pharmacist or doctor before mixing the two, and check your glucose closely if you do.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Kifle ZD, Yesuf JS, Atnafie SA. Evaluation of in vitro and in vivo Anti-Diabetic, Anti-Hyperlipidemic and Anti-Oxidant Activity of Flower Crude Extract and Solvent Fractions of Hagenia Abyssinica (Rosaceae). J Exp Pharmacol. 2020 Jun 9;12:151-167.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Kousso Also Interacts With Other Medications

Kousso has 85 moderate known drug interactions in our database — the Insulin Glargine one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Insulin Glargine)
Taking anything else?

Check Another of Your Medications Against Kousso

Covers the 2,830 medications we’ve checked against Kousso. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Insulin Glargine

This page covers Kousso only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin Glargine page lists 242 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Chelation Therapy Products (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 211 moderate · 29 minor.

Open the Insulin Glargine interaction page

How much people look this up

Where Kousso and Insulin Glargine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Kousso
Steady interest

#1,186 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Insulin Glargine
Top half

#1,394 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Kousso

What is Kousso?

  • Tapeworm infection (traditional anthelmintic)
  • Other intestinal worms
  • Traditional digestive remedies

Kousso is the dried flower of the African tree Hagenia abyssinica, used traditionally—especially in Ethiopia—to expel tapeworms. It was once listed in older pharmacopeias as a worm treatment, but it has largely been replaced by safer, more reliable modern medicines and can cause significant side effects. There is no good modern evidence supporting its use, so talk to a pharmacist or doctor before considering it.

Read the full Kousso monograph & all interactions
Medication

About Insulin Glargine (rDNA origin) Injection

What Is Insulin Glargine (rDNA origin) Injection Used For?

Brand names: Basaglar, Lusduna, Semglee

Insulin glargine is used to improve glycemic control (blood sugar management) in adults and pediatric patients with type 1 diabetes mellitus, and in adults with type 2 diabetes mellitus. It is a long-acting basal insulin, meaning it works gradually over the course of the day to keep blood sugar steady.

Insulin glargine is not recommended for treating diabetic ketoacidosis (a serious complication where the blood becomes dangerously acidic).

See full Insulin Glargine (rDNA origin) Injection drug information
Keep checking

Other Drugs & Kousso

Browse every other medication we’ve checked against Kousso — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Kousso page.

No interaction 2,744 drugs checked — show the list

We also checked Kousso against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Kousso list.

See the full Kousso interactions page
See every supplement checked against Insulin Glargine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Kousso monograph › Uses, safety, and every drug interaction in one place Insulin Glargine supplement interactions › Every supplement checked against Insulin Glargine, ranked by severity Insulin Glargine (rDNA origin) Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Kousso and Insulin Glargine Together: Common Questions

Can you take Kousso with Insulin Glargine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Kousso and Insulin Glargine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Insulin Glargine and Kousso?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.