Drug & supplement interaction

Lactobacillus Gasseri + Pyrazinamide

Pyrazinamide brand name: Tebrazid.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Lactobacillus Gasseri has a moderate interaction with Pyrazinamide. Theoretically, taking Lactobacillus gasseri with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Lactobacillus Gasseri and Pyrazinamide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIBIOTIC DRUGS

Why this applies to Pyrazinamide

Pyrazinamide falls under ANTIBIOTIC DRUGS — the group Lactobacillus Gasseri interacts with.

Theoretically, taking Lactobacillus gasseri with antibiotic drugs might decrease the effectiveness of L. gasseri.
Lactobacillus gasseri preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. gasseri preparations by at least two hours.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know about pairing a Lactobacillus gasseri probiotic with pyrazinamide: the concern runs in one direction only. Pyrazinamide is an antibiotic that kills the bacteria causing tuberculosis, but it can't tell the difference between harmful bugs and the friendly probiotic organisms you swallowed. So taking them at the same time may wipe out a chunk of the live cultures, making your probiotic less effective. It does not make pyrazinamide weaker or more toxic, and it won't change how your TB treatment works.

This is a theoretical, pharmacology-based concern rather than something proven in studies, so don't panic. A simple fix helps: just separate the two by at least two hours. And please keep taking your TB medicine exactly as prescribed, checking with your pharmacist if you have questions.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Lactobacillus Gasseri Also Interacts With Other Medications

Lactobacillus Gasseri has 181 moderate known drug interactions in our database — the Pyrazinamide one above is one of them. If you take anything else, check it against the full list below.

Moderate 181 No known interaction 2,649 (incl. Pyrazinamide)
Taking anything else?

Check Another of Your Medications Against Lactobacillus Gasseri

Covers the 2,830 medications we’ve checked against Lactobacillus Gasseri. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Pyrazinamide

This page covers Lactobacillus Gasseri only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pyrazinamide page lists 102 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Alfalfa (moderate).

By severity: 4 major · 86 moderate · 12 minor.

From our pharmacist’s overview on the Pyrazinamide page

“Pyrazinamide is one of the core tuberculosis drugs, and because treatment runs for months while the liver already carries the drug's own strain, the 102 supplements and herbs on file here warrant real caution. Thirty-eight of them add their own liver stress, and three of the four major-rated entries sit in that group, including somethi…”

Reviewed by 2 · Jul 18, 2026

Open the Pyrazinamide interaction page

One more smart check

Taking Lactobacillus Gasseri as Part of a Dietary Supplement Product? Check It for Interactions

We hold 852 real supplement products containing Lactobacillus Gasseri, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lactobacillus Gasseri. Your product may carry other ingredients that interact with Pyrazinamide too, on top of Lactobacillus Gasseri — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lactobacillus Gasseri and Pyrazinamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lactobacillus Gasseri
Top 25%

#277 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pyrazinamide
Top half

#1,122 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Lactobacillus Gasseri

What is Lactobacillus Gasseri?

  • Digestive health
  • Weight and belly fat management
  • Vaginal and urinary health
  • Bloating and gut discomfort
  • General immune support

Lactobacillus gasseri is a 'friendly' probiotic bacterium found naturally in the human gut, mouth, and vaginal tract, and in some fermented foods. Early research suggests it may help with digestion, weight management, and vaginal health, but the evidence is limited and far from conclusive. It is generally well tolerated in healthy people, but anyone who is pregnant, breastfeeding, or has a weakened immune system should talk to a pharmacist or doctor first.

Read the full Lactobacillus Gasseri monograph & all interactions
Medication

About Pyrazinamide

What Is Pyrazinamide Used For?

Brand name: Tebrazid

Pyrazinamide tablets are used to treat active tuberculosis (TB) in adults and children. It is always used in combination with other anti-TB medicines — never alone. The standard CDC-recommended approach uses pyrazinamide as part of a 6-month regimen, typically for the first 2 months.

It is also used when initial TB treatment with other drugs has failed. People with drug-resistant TB or with HIV infection may need a treatment plan specifically tailored to their situation, which can include pyrazinamide as a key part of the regimen.

See full Pyrazinamide drug information
Keep checking

Other Drugs & Lactobacillus Gasseri

Browse every other medication we’ve checked against Lactobacillus Gasseri — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
181Moderate
0Minor
2,648No known interaction
181 Moderate 2,648 No interaction
Moderate

181 interactions

Showing 60 of 181 moderate interactions — see all 181 on the Lactobacillus Gasseri page.

No interaction 2,648 drugs checked — show the list

We also checked Lactobacillus Gasseri against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,648 medications checked with no known interaction — see the full Lactobacillus Gasseri list.

See the full Lactobacillus Gasseri interactions page
See every supplement checked against Pyrazinamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Lactobacillus Gasseri monograph › Uses, safety, and every drug interaction in one place Pyrazinamide supplement interactions › Every supplement checked against Pyrazinamide, ranked by severity Pyrazinamide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Lactobacillus Gasseri and Pyrazinamide Together: Common Questions

Can you take Lactobacillus Gasseri with Pyrazinamide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Lactobacillus Gasseri and Pyrazinamide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Pyrazinamide and Lactobacillus Gasseri?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.