Drug & supplement interaction

Ligandrol + Botulinum Toxin Type A

Botulinum Toxin Type A brand name: Botox.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Ligandrol and Botulinum Toxin Type A in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Ligandrol and Botulinum Toxin Type A

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Botulinum Toxin Type A and Ligandrol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ligandrol safety at a glance

Ligandrol overall Avoid Ligandrol is an unapproved investigational drug with real safety concerns and is not a legal dietary supplement.
Pregnancy Possibly Unsafe When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androge... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androge... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Botulinum Toxin Type A and Ligandrol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Ligandrol Does Interact With Other Medications

Ligandrol has 370 moderate known drug interactions in our database — Botulinum Toxin Type A isn’t one of them. If you take anything else, check it against the full list below.

Moderate 370 No known interaction 2,460 (incl. Botulinum Toxin Type A)
Taking anything else?

Check Another of Your Medications Against Ligandrol

Covers the 2,830 medications we’ve checked against Ligandrol. Pick one to open its full report.

What to actually watch for

What Ligandrol Itself Has Been Linked To

This is not an interaction — nothing below involves Botulinum Toxin Type A. It is the side-effect record for Ligandrol on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Ligandrol, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Yellowing of the skin or eyes / Liver problems Worth acting on Additional detail

    “There are cases of liver injury thought to be related to the use of ligandrol alone or in combination with other SARMs. The U.S. Food and Drug Administration (FDA) has warned that supplements containing SARMs, such as ligandrol, have been associated with liver toxicity.

    There are at least 3 cases of liver injury thought to be related to the use of ligandrol alone.”

    Ligandrol · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 94879. Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
    2. 94880. Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
    3. 94881. Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
    4. 112650. Barbara M, Dhingra S, Mindikoglu AL. Ligandrol (LGD-4033)-Induced Liver Injury. ACG Case Rep J 2020;7(6):e00370. PubMed
    5. 112682. Koller T, Vrbova P, Meciarova I, et al. Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and literature review. World J Clin Cases 2021;9(16):4062-4071. PubMed
    6. 112683. Flores JE, Chitturi S, Walker S. Drug-induced liver injury by selective androgenic receptor modulators. Hepatol Commun. 2020;4(3):450-452. PubMed
  • Weight loss / Itching / Stomach pain / Tiredness / Diarrhea / Nausea Additional detail

    Recorded for Ligandrol in the same Natural Medicines adverse-effect record shown under Yellowing of the skin or eyes / Liver problems above.

Everything above comes from the Natural Medicines adverse-effect record for Ligandrol — expand a row for the licensed statement it rests on. We haven’t matched Botulinum Toxin Type A to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Botulinum Toxin Type A.

Special populations

Ligandrol in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androgen receptor modulators (SARMs) are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Botulinum Toxin Type A Is Prescribed For, and What Ligandrol Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Botulinum Toxin Type A is a prescription medicine with approved uses on its FDA label. Ligandrol is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Botulinum Toxin Type A is prescribed for: Botox is approved to treat a wide range of conditions in adults and some children. These include overactive bladder (OAB) with urge incontinence, urinary incontinence caused by nerve-related bladder overactivity (in adults and in children aged 5 and older), prevention of headaches in adults with chronic migraine (15 or more headache days per month), muscle stiffness (spasticity) in patients aged 2 and older, cervical dystonia (abnormal head position and neck pain), severe underarm sweating (primary axillary hyperhidrosis) when topical treatments haven't worked, eyelid spasms (blepharospasm) in patients aged 12 and older, and crossed eyes (strabismus) in patients aged 12 and older. BOTOX Cosmetic is a separate product containing the same active ingredient but with its own approved cosmetic uses. Both products are given by injection and are not interchangeable with other botulinum toxin products.

Read the rest of what Botulinum Toxin Type A is prescribed for

Botox has not been shown to work for episodic migraine (14 or fewer headache days per month), and its safety for excessive sweating in body areas other than the underarms has not been established.

Ligandrol has been studied for:

  • Urinary incontinence studied, not established Ligandrol has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Ligandrol for urinary incontinence

    Although there is interest in using oral ligandrol for urinary incontinence, there is insufficient reliable information about the clinical effects of ligandrol for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Botulinum Toxin Type A on your own; if you are taking Ligandrol for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Ligandrol or Botulinum Toxin Type A

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ligandrol or Botulinum Toxin Type A, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

One more smart check

Taking Ligandrol as Part of a Dietary Supplement Product? Check It for Interactions

We hold 26 real supplement products containing Ligandrol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ligandrol. Even though Ligandrol itself has no known interaction with Botulinum Toxin Type A, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ligandrol and Botulinum Toxin Type A Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ligandrol
Steady interest

#760 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Botulinum Toxin Type A
Top half

#742 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ligandrol reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ligandrol and Botulinum Toxin Type A records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ligandrol

What is Ligandrol?

  • Muscle building
  • Athletic performance and strength
  • Body recomposition
  • Bodybuilding cycles

Ligandrol (LGD-4033) is a synthetic selective androgen receptor modulator (SARM), not a natural herb or approved dietary supplement. It is not approved for human use, is banned in sports, and has been linked to liver injury and hormonal disruption, so it should not be taken as a supplement.

Not applicable (synthetic compound) · Capsules, tablets, liquid (research chemical), powder

An interaction check asks whether these two react with each other — it does not ask whether Ligandrol is a good idea for someone in your situation. Here is what our Ligandrol record says about it on its own.

Ligandrol: dosing

There is no established or approved safe dose of Ligandrol because it is not an approved medicine or legal supplement. Doses used in early research and in bodybuilding are not verified for safety, and product labels cannot be trusted to be accurate.Because of the real risks and the lack of an approved dose, the safest choice is not to take it at all.

From our Ligandrol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ligandrol monograph & all interactions
Medication

About OnabotulinumtoxinA Injection

What Is OnabotulinumtoxinA Injection Used For?

Brand name: Botox

Botox is approved to treat a wide range of conditions in adults and some children. These include overactive bladder (OAB) with urge incontinence, urinary incontinence caused by nerve-related bladder overactivity (in adults and in children aged 5 and older), prevention of headaches in adults with chronic migraine (15 or more headache days per month), muscle stiffness (spasticity) in patients aged 2 and older, cervical dystonia (abnormal head position and neck pain), severe underarm sweating (primary axillary hyperhidrosis) when topical treatments haven't worked, eyelid spasms (blepharospasm) in patients aged 12 and older, and crossed eyes (strabismus) in patients aged 12 and older.

BOTOX Cosmetic is a separate product containing the same active ingredient but with its own approved cosmetic uses. Both products are given by injection and are not interchangeable with other botulinum toxin products. Botox has not been shown to work for episodic migraine (14 or fewer headache days per month), and its safety for excessive sweating in body areas other than the underarms has not been established.

Most-Reported Side Effects for Botulinum Toxin Type A

From FAERS, the FDA’s public side-effect reporting system (12,344 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 1,596 reports
Drug intolerance 1,333 reports
Nausea 1,266 reports
Migraine 1,176 reports
Dizziness 1,126 reports
See full OnabotulinumtoxinA Injection drug information
Keep checking

Other Drugs & Ligandrol

Browse every other medication we’ve checked against Ligandrol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
370Moderate
0Minor
2,459No known interaction
370 Moderate 2,459 No interaction
Moderate

370 interactions

Showing 60 of 370 moderate interactions — see all 370 on the Ligandrol page.

No interaction 2,459 drugs checked — show the list

We also checked Ligandrol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,459 medications checked with no known interaction — see the full Ligandrol list.

See the full Ligandrol interactions page
See every supplement checked against Botulinum Toxin Type A, ranked by severity
Evidence & sources

Ligandrol References

The 9 references that drive our Ligandrol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
  3. Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
  4. Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
  5. Barbara M, Dhingra S, Mindikoglu AL. Drug-induced liver injury associated with alpha bolic (RAD-140) and alpha elite (RAD-140 and LGD-4033). ACG Case Rep J 2020;7(6):e00409. PubMed
  6. Barbara M, Dhingra S, Mindikoglu AL. Ligandrol (LGD-4033)-Induced Liver Injury. ACG Case Rep J 2020;7(6):e00370. PubMed
  7. Koller T, Vrbova P, Meciarova I, et al. Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and literature review. World J Clin Cases 2021;9(16):4062-4071. PubMed
  8. Flores JE, Chitturi S, Walker S. Drug-induced liver injury by selective androgenic receptor modulators. Hepatol Commun. 2020;4(3):450-452. PubMed
  9. Basaria S, Collins L, Dillon EL, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci 2013;68(1):87-95. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ligandrol and Botulinum Toxin Type A Together: Common Questions

Is it safe to take Ligandrol with Botulinum Toxin Type A?
We do not list a known interaction between Ligandrol and Botulinum Toxin Type A. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Ligandrol and Botulinum Toxin Type A used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Ligandrol in each. That is a conversation for your prescriber, especially if Botulinum Toxin Type A is being adjusted to a target.
Does Ligandrol interact with any other medications?
Yes. Ligandrol has 370 documented drug interactions in our database — Botulinum Toxin Type A is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ligandrol monograph Uses, safety profile, and every drug interaction in one place OnabotulinumtoxinA Injection drug information The full plain-English guide to this medication Botulinum Toxin Type A supplement interactions Every supplement checked against Botulinum Toxin Type A, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Botulinum Toxin Type A and Ligandrol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.