Drug & supplement interaction

Lotus + Aspirin, Pentazocine

Aspirin, Pentazocine brand name: Talwin Compound.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Lotus has a moderate interaction with Aspirin, Pentazocine. Theoretically, concurrent use of lotus with other antiplatelet drugs might reduce platelet aggregation and increase the risk of bleeding.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Lotus and Aspirin, Pentazocine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Aspirin, Pentazocine

Aspirin, Pentazocine falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Lotus interacts with.

Theoretically, concurrent use of lotus with other antiplatelet drugs might reduce platelet aggregation and increase the risk of bleeding.
Neferine and isoliensinine, constituents of lotus, have been shown to inhibit platelet aggregation, in vitro. These constituents can inhibit the production of pro-aggregating factors like prostaglandins.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing with Talwin Compound: it contains aspirin, which already thins your blood a little by keeping platelets from clumping together. Lotus, at least in lab studies, seems to do something similar. Two of its natural compounds (neferine and isoliensinine) blocked platelet activity in test-tube experiments, so stacking them on top of aspirin could, in theory, push the blood-thinning effect a bit further.

What might that look like in real life? Easier bruising, nosebleeds, bleeding gums, or cuts that take longer to stop. I'll be honest though, this is theoretical, based on how the plant behaves in a lab, not in people. Eating lotus as food is unlikely to be a problem. Concentrated lotus supplements are where I'd pause, so check with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Yu, J. and Hu, W. S. [Effects of neferine on platelet aggregation in rabbits]. Yao Xue.Xue.Bao. 1997;32(1):1-4.
  2. Yang, J. and Zhou, K. NMR spectroscopic analysis of neferine and isoliensinine. Magn Reson.Chem 2004;42(11):994-997. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Lotus Also Interacts With Other Medications

Lotus has 211 moderate known drug interactions in our database — the Aspirin, Pentazocine one above is one of them. If you take anything else, check it against the full list below.

Moderate 211 No known interaction 2,619 (incl. Aspirin, Pentazocine)
Taking anything else?

Check Another of Your Medications Against Lotus

Covers the 2,830 medications we’ve checked against Lotus. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aspirin, Pentazocine

This page covers Lotus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Pentazocine page lists 336 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 11 major · 283 moderate · 42 minor.

From our pharmacist’s overview on the Aspirin, Pentazocine page

“Talwin Compound pairs pentazocine, an opioid painkiller, with aspirin, and I read its supplement list with more concern than most. The great majority of entries do one of two things: raise the bleeding risk that aspirin already carries, or deepen the sedation pentazocine causes.”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Pentazocine interaction page

One more smart check

Taking Lotus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 256 real supplement products containing Lotus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lotus. Your product may carry other ingredients that interact with Aspirin, Pentazocine too, on top of Lotus — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lotus and Aspirin, Pentazocine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lotus
Top half

#394 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Pentazocine
Top 25%

#292 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Lotus

What is Lotus?

Lotus
  • Digestive upset and diarrhea
  • Anxiety and relaxation
  • Sleep support
  • Blood sugar and cholesterol support
  • Skin and general wellness

Lotus is an edible aquatic plant used in food and traditional medicine across Asia, with parts like the seeds, leaves, and flowers taken for digestion, calm, and overall wellness. Most health claims come from laboratory and animal research rather than strong human studies, so its benefits as a supplement are not well proven. Eating lotus as food is generally safe, but talk to your pharmacist or doctor before using concentrated supplements, especially if you are pregnant, breastfeeding, or taking other medicines.

Read the full Lotus monograph & all interactions
Keep checking

Other Drugs & Lotus

Browse every other medication we’ve checked against Lotus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
211Moderate
0Minor
2,618No known interaction
211 Moderate 2,618 No interaction
Moderate

211 interactions

Showing 60 of 211 moderate interactions — see all 211 on the Lotus page.

No interaction 2,618 drugs checked — show the list

We also checked Lotus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,618 medications checked with no known interaction — see the full Lotus list.

See the full Lotus interactions page
See every supplement checked against Aspirin, Pentazocine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Lotus monograph › Uses, safety, and every drug interaction in one place Aspirin, Pentazocine supplement interactions › Every supplement checked against Aspirin, Pentazocine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Lotus and Aspirin, Pentazocine Together: Common Questions

Can you take Lotus with Aspirin, Pentazocine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Lotus and Aspirin, Pentazocine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Aspirin, Pentazocine and Lotus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.