Medication interaction hub

What Supplements Interact with Aspirin, Pentazocine?

Aspirin, Pentazocine brand name: Talwin Compound. Every interaction below applies to the brands too.

336 Interactions 11 Major 283 Moderate 42 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Aspirin, Pentazocine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Aspirin, Pentazocine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Talwin Compound pairs pentazocine, an opioid painkiller, with aspirin, and I read its supplement list with more concern than most. The great majority of entries do one of two things: raise the bleeding risk that aspirin already carries, or deepen the sedation pentazocine causes. Alcohol sits at the top of the sedation side (beer and wine both carry the highest severity rating, backed by human studies), along with kava, and with an opioid on board, heavy sedation can shade into dangerously slowed breathing.

Smaller clusters interfere with the tablet's absorption, bulky fibers and charcoal products mainly, so keep those well separated from your doses and let the full report and your pharmacist settle the details. A handful can stress the kidneys, worth knowing with steady aspirin use. All told the page lists 336 ingredients, 283 of them moderate and 42 minor, but the 11 rated major are where I would start reading.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 283 Minor 42 No known interaction 1,116

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Aspirin, Pentazocine: Top Interactions at a Glance

The Aspirin, Pentazocine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 336 interacting ingredients — plus 1,116 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Aspirin, Pentazocine Combinations Today

The Aspirin, Pentazocine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Holy Basil + Aspirin, Pentazocinei

Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Oregano + Aspirin, Pentazocinei

Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Guarana + Aspirin, Pentazocinei

Theoretically, guarana may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Minor Likelihood Unlikely Mullein + Aspirin, Pentazocinei

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the...

Read the full interaction Moderate Likelihood Possible Nattokinase + Aspirin, Pentazocinei

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Panax Notoginseng + Aspirin, Pentazocinei

Theoretically, taking Panax notoginseng might reduce the levels and clinical effects of CYP1A2 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Aspirin, Pentazocine

All 1,452 ingredients in our database, ranked by severity — 336 with a Aspirin, Pentazocine interaction on file and 1,116 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Aspirin, Pentazocine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Holy Basil with Aspirin, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.

Full Holy Basil + Aspirin, Pentazocine answer

Can you take Oregano with Aspirin, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Oregano + Aspirin, Pentazocine answer

Can you take Guarana with Aspirin, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guarana may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Guarana + Aspirin, Pentazocine answer

Can you take Mullein with Aspirin, Pentazocine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, a...

Full Mullein + Aspirin, Pentazocine answer

Can you take Nattokinase with Aspirin, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Full Nattokinase + Aspirin, Pentazocine answer

Can you take 1,4-butanediol with Aspirin, Pentazocine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Full 1,4-butanediol + Aspirin, Pentazocine answer

Can you take Activated Charcoal with Aspirin, Pentazocine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Aspirin, Pentazocine answer

Can you take Danshen with Aspirin, Pentazocine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Danshen + Aspirin, Pentazocine answer

Can you take Gamma-hydroxybutyrate (ghb) with Aspirin, Pentazocine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. GHB may increase the risk of serious CNS and respiratory depression.

Full Gamma-hydroxybutyrate (ghb) + Aspirin, Pentazocine answer

Can you take Kava with Aspirin, Pentazocine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Combining kava with CNS depressants can have additive sedative effects.

Full Kava + Aspirin, Pentazocine answer

Can you take L-tryptophan with Aspirin, Pentazocine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.

Full L-tryptophan + Aspirin, Pentazocine answer

Can you take Piracetam with Aspirin, Pentazocine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of piracetam and anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Full Piracetam + Aspirin, Pentazocine answer

Can you take Asarabacca with Aspirin, Pentazocine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Full Asarabacca + Aspirin, Pentazocine answer

Can you take Bridelia with Aspirin, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animals, orally administered extracts of Bridelia ferruginea stem bark inhibit ADP/adrenaline-induced thrombosis by approximately 62%.The...

Full Bridelia + Aspirin, Pentazocine answer

Can you take Cannabidiol (cbd) with Aspirin, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabidiol may increase levels of drugs metabolized by CYP1A2.

Full Cannabidiol (cbd) + Aspirin, Pentazocine answer

Can you take Coffee Charcoal with Aspirin, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Aspirin, Pentazocine answer

Can you take European Mandrake with Aspirin, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Aspirin, Pentazocine answer

Can you take Evodia with Aspirin, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evodia might reduce the levels and clinical effects of CYP1A2 substrates through induction of CYP1A2.

Full Evodia + Aspirin, Pentazocine answer

Can you take Glucomannan with Aspirin, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Aspirin, Pentazocine answer

Can you take Lithium with Aspirin, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking lithium supplements with NSAIDs might increase lithium levels and adverse effects.

Full Lithium + Aspirin, Pentazocine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Aspirin, Pentazocine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Aspirin, Pentazocine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Aspirin, Pentazocine sits in 13 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Aspirin, Pentazocine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Aspirin, Pentazocine through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Aspirin, Pentazocine through this category.

Aspirin 22 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

22 of the supplement ingredients on this page reach Aspirin, Pentazocine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Pentazocine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Pentazocine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Pentazocine through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Pentazocine through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Pentazocine through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Pentazocine through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Pentazocine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Aspirin, Pentazocine through this category.

Pentazocine (Talwin) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Aspirin, Pentazocine through this category.

Related: does Aspirin, Pentazocine deplete any nutrients?

Aspirin, Pentazocine has 4 reported nutrient associations in the research literature — see the Aspirin, Pentazocine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Aspirin, Pentazocine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Aspirin, Pentazocine.

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Products that contain Aspirin, Pentazocine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Aspirin, Pentazocine.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Aspirin, Pentazocine & Supplements: Common Questions

What supplements interact with Aspirin, Pentazocine?
Our database currently documents 336 ingredients with a known Aspirin, Pentazocine interaction (11 major, 283 moderate, 42 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 336. The highest-ranked right now: Beer, Siberian Cocklebur, Wine.
Which Aspirin, Pentazocine supplement interactions are the most serious?
Focus on the major group: Beer, Siberian Cocklebur, Wine, 1,4-butanediol and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Aspirin, Pentazocine?
Plenty of supplements coexist fine with Aspirin, Pentazocine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Talwin Compound have the same supplement interactions as Aspirin, Pentazocine?
Yes — Talwin Compound all contain Aspirin, Pentazocine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Aspirin, Pentazocine deplete any vitamins or nutrients?
It might — Aspirin, Pentazocine has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Aspirin, Pentazocine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Aspirin, Pentazocine and my other medications?
This page covers Aspirin, Pentazocine against supplements and herbal ingredients. Checking Aspirin, Pentazocine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.