Drug & supplement interaction

Meadowsweet + Aspirin, Pentazocine

Aspirin, Pentazocine brand name: Talwin Compound.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Meadowsweet has a moderate interaction with Aspirin, Pentazocine. Theoretically, meadowsweet might have an additive effect with other salicylate-containing drugs, such as aspirin.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Meadowsweet and Aspirin, Pentazocine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ASPIRIN

Theoretically, meadowsweet might have an additive effect with other salicylate-containing drugs, such as aspirin.
Meadowsweet contains salicin, a plant salicylate; however, salicin doesn't seem to have the antiplatelet effects of aspirin.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Talwin Compound combines pentazocine (a pain reliever) with aspirin. Here's the thing about meadowsweet: it carries its own natural aspirin-like compounds called salicylates. So when you pair it with a product that already contains aspirin, you're essentially stacking similar ingredients on top of each other. In theory, that could nudge your total salicylate load a little higher.

What might that look like? Mostly the familiar aspirin-type stuff: stomach upset, heartburn, ringing in the ears, or a bit more risk of stomach irritation. I want to be honest though, this concern is theoretical and based on pharmacology, not strong studies, and the salicin in meadowsweet doesn't seem to thin the blood the way aspirin does. Still, if you're sensitive to aspirin, check with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Meadowsweet Also Interacts With Other Medications

Meadowsweet has 38 moderate known drug interactions in our database — the Aspirin, Pentazocine one above is one of them. If you take anything else, check it against the full list below.

Moderate 38 No known interaction 2,792 (incl. Aspirin, Pentazocine)
Taking anything else?

Check Another of Your Medications Against Meadowsweet

Covers the 2,830 medications we’ve checked against Meadowsweet. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aspirin, Pentazocine

This page covers Meadowsweet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Pentazocine page lists 336 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 11 major · 283 moderate · 42 minor.

From our pharmacist’s overview on the Aspirin, Pentazocine page

“Talwin Compound pairs pentazocine, an opioid painkiller, with aspirin, and I read its supplement list with more concern than most. The great majority of entries do one of two things: raise the bleeding risk that aspirin already carries, or deepen the sedation pentazocine causes.”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Pentazocine interaction page

One more smart check

Taking Meadowsweet as Part of a Dietary Supplement Product? Check It for Interactions

We hold 197 real supplement products containing Meadowsweet, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Meadowsweet. Your product may carry other ingredients that interact with Aspirin, Pentazocine too, on top of Meadowsweet — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Meadowsweet and Aspirin, Pentazocine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Meadowsweet
Top half

#436 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Pentazocine
Top 25%

#343 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Meadowsweet

What is Meadowsweet?

Meadowsweet
  • Heartburn and indigestion
  • Cold and flu symptoms
  • Mild aches and pains
  • Fever
  • Joint discomfort

Meadowsweet is a traditional European herb that contains natural salicylates (aspirin-like compounds) and is used mainly for digestive upset, colds, and minor aches. High-quality human studies are lacking, so its benefits are not well proven, and people sensitive to aspirin should be cautious. Talk with your pharmacist or doctor before using it.

Read the full Meadowsweet monograph & all interactions
Keep checking

Other Drugs & Meadowsweet

Browse every other medication we’ve checked against Meadowsweet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
38Moderate
0Minor
2,791No known interaction
38 Moderate 2,791 No interaction
Moderate

38 interactions

No interaction 2,791 drugs checked — show the list

We also checked Meadowsweet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,791 medications checked with no known interaction — see the full Meadowsweet list.

See the full Meadowsweet interactions page
See every supplement checked against Aspirin, Pentazocine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Meadowsweet monograph › Uses, safety, and every drug interaction in one place Aspirin, Pentazocine supplement interactions › Every supplement checked against Aspirin, Pentazocine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Meadowsweet and Aspirin, Pentazocine Together: Common Questions

Can you take Meadowsweet with Aspirin, Pentazocine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Meadowsweet and Aspirin, Pentazocine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Aspirin, Pentazocine and Meadowsweet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.