Drug & supplement interaction

Lousewort + Hydrocodone, Pseudoephedrine, Chlorpheniramine

Hydrocodone, Pseudoephedrine, Chlorpheniramine brand name: Zutripro.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Lousewort and Hydrocodone, Pseudoephedrine, Chlorpheniramine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Lousewort and Hydrocodone, Pseudoephedrine, Chlorpheniramine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hydrocodone, Pseudoephedrine, Chlorpheniramine and Lousewort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Lousewort at all — not against Hydrocodone, Pseudoephedrine, Chlorpheniramine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lousewort safety at a glance

Lousewort overall Not established Human safety data are very limited, and some Pedicularis species may contain potentially toxic alkaloids.
Pregnancy Avoid No reliable safety data exist, so it should be avoided during pregnancy.
Breastfeeding Avoid No safety information is available, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hydrocodone, Pseudoephedrine, Chlorpheniramine and Lousewort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Everything else you take

See Every Supplement That Interacts With Hydrocodone, Pseudoephedrine, Chlorpheniramine

This page covers Lousewort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrocodone, Pseudoephedrine, Chlorpheniramine page lists 285 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Ephedra (major) and Gamma-hydroxybutyrate (ghb) (major).

By severity: 16 major · 228 moderate · 41 minor.

From our pharmacist’s overview on the Hydrocodone, Pseudoephedrine, Chlorpheniramine page

“Zutripro pairs an opioid (hydrocodone) with a decongestant and a sedating antihistamine, which means supplements can interfere from three directions at once, and with 16 major-rated interactions among the 285 on file, this is a list to treat with genuine respect. The biggest cluster, 78 sedating ingredients including alcohol in any for…”

Reviewed by 2 · Jul 18, 2026

Open the Hydrocodone, Pseudoephedrine, Chlorpheniramine interaction page

How much people look this up

Where Lousewort and Hydrocodone, Pseudoephedrine, Chlorpheniramine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lousewort
Steady interest

#795 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydrocodone, Pseudoephedrine, Chlorpheniramine
Steady interest

#2,592 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Lousewort is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lousewort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Lousewort and Hydrocodone, Pseudoephedrine, Chlorpheniramine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lousewort

What is Lousewort?

  • Muscle relaxation
  • Sleep and relaxation
  • Mild pain relief
  • Stress and tension

Lousewort refers to several plants in the Pedicularis genus, traditionally used as a mild muscle relaxant and calming herb. There is very little scientific research on its safety or effectiveness in humans, and some species may contain toxic compounds, so caution is strongly advised.

Pedicularis spp. · Orobanchaceae · Aerial parts (flowers, leaves, and stems) · Tea, tincture, dried herb, capsules, smoking blends

An interaction check asks whether these two react with each other — it does not ask whether Lousewort is a good idea for someone in your situation. Here is what our Lousewort record says about it on its own.

Lousewort: dosing

There is no established standard dose for lousewort. Traditional use varies widely, and no clinical studies have determined a safe or effective amount.If you choose to use a product, follow the directions on the label and start with the lowest suggested amount.

From our Lousewort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lousewort monograph & all interactions
Keep checking

Other Drugs & Lousewort

Browse every other medication we’ve checked against Lousewort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Lousewort References

The 1 sources that drive our Lousewort monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Lousewort is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Using Dietary Supplements Wisely — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lousewort and Hydrocodone, Pseudoephedrine, Chlorpheniramine Together: Common Questions

Is it safe to take Lousewort with Hydrocodone, Pseudoephedrine, Chlorpheniramine?
We do not list a known interaction between Lousewort and Hydrocodone, Pseudoephedrine, Chlorpheniramine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Hydrocodone, Pseudoephedrine, Chlorpheniramine interact with any supplements?
Yes. Hydrocodone, Pseudoephedrine, Chlorpheniramine has documented interactions with 285 supplements in our database — Lousewort is not one of them. The Hydrocodone, Pseudoephedrine, Chlorpheniramine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Hydrocodone, Pseudoephedrine, Chlorpheniramine and Lousewort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.