Medication interaction hub

What Supplements Interact with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Hydrocodone, Pseudoephedrine, Chlorpheniramine brand name: Zutripro. Every interaction below applies to the brands too.

285 Interactions 16 Major 228 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hydrocodone, Pseudoephedrine, Chlorpheniramine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hydrocodone, Pseudoephedrine, Chlorpheniramine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Zutripro pairs an opioid (hydrocodone) with a decongestant and a sedating antihistamine, which means supplements can interfere from three directions at once, and with 16 major-rated interactions among the 285 on file, this is a list to treat with genuine respect. The biggest cluster, 78 sedating ingredients including alcohol in any form, adds drowsiness and slowed breathing on top of the hydrocodone, the riskiest kind of stacking with an opioid. Another 121 share the liver enzyme (CYP3A4) that clears hydrocodone, so grapefruit can raise its levels while St. John's wort drops them.

Forty-four stimulant herbs push pseudoephedrine's heart rate and blood pressure effects further, and 30 more pile onto chlorpheniramine's dry mouth and constipation. Most of the 285 rate moderate (228 of them) and 41 minor, but read the 16 majors first, since several involve everyday things like a glass of wine or grapefruit juice at breakfast.

— , Clinical Pharmacist · July 18, 2026

Major 16 Moderate 228 Minor 41 No known interaction 1,167

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Hydrocodone, Pseudoephedrine, Chlorpheniramine: Top Interactions at a Glance

The Hydrocodone, Pseudoephedrine, Chlorpheniramine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 285 interacting ingredients — plus 1,167 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Hydrocodone, Pseudoephedrine, Chlorpheniramine Combinations Today

The Hydrocodone, Pseudoephedrine, Chlorpheniramine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Black Tea + Hydrocodone, Pseudoephedrine, Chlorpheniraminei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Possible German Chamomile + Hydrocodone, Pseudoephedrine, Chlorpheniraminei

Theoretically, German chamomile might have additive effects when used with CNS depressants.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Hydrocodone, Pseudoephedrine, Chlorpheniraminei

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction Moderate Likelihood Possible Eucalyptus + Hydrocodone, Pseudoephedrine, Chlorpheniraminei

Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Horny Goat Weed + Hydrocodone, Pseudoephedrine, Chlorpheniraminei

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.

Read the full interaction Minor Likelihood Possible Karaya Gum + Hydrocodone, Pseudoephedrine, Chlorpheniraminei

Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption of drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Hydrocodone, Pseudoephedrine, Chlorpheniramine

All 1,452 ingredients in our database, ranked by severity — 285 with a Hydrocodone, Pseudoephedrine, Chlorpheniramine interaction on file and 1,167 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hydrocodone, Pseudoephedrine, Chlorpheniramine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Tea with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Black Tea + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take German Chamomile with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might have additive effects when used with CNS depressants.

Full German Chamomile + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take Gamma-hydroxybutyrate (ghb) with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. GHB may increase the risk of serious CNS and respiratory depression.

Full Gamma-hydroxybutyrate (ghb) + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take Eucalyptus with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Full Eucalyptus + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take Horny Goat Weed with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.

Full Horny Goat Weed + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take Pu-erh Tea with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Pu-erh Tea + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take Schisandra with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Schisandra + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take Sodium Bicarbonate with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sodium bicarbonate may increase levels and adverse effects of pseudoephedrine.

Full Sodium Bicarbonate + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take Syrian Rue with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP2D6.

Full Syrian Rue + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take Tree Turmeric with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.

Full Tree Turmeric + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take Wild Carrot with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might result in increased photosensitivity.

Full Wild Carrot + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take Yerba Mansa with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might cause additive or prolonged sedative effects.

Full Yerba Mansa + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take Yerba Mate with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of stimulant drugs and yerba mate might increase stimulant adverse effects.

Full Yerba Mate + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take Yohimbe with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.

Full Yohimbe + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take 1,3-dmaa with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 1,3-DMAA strongly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.

Full 1,3-dmaa + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take 1,3-dmba with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining 1,3-DMBA with other stimulant drugs might increase the risk of cardiovascular toxicity.

Full 1,3-dmba + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take 1,4-dmaa with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 1,4-DMAA is thought to have stimulant and vasoconstrictive effects, which have been demonstrated in animal studies.

Full 1,4-dmaa + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take 5-htp with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.

Full 5-htp + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take Acacia Rigidula with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP2D6 su...

Full Acacia Rigidula + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer

Can you take Acetyl-l-carnitine with Hydrocodone, Pseudoephedrine, Chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstr...

Full Acetyl-l-carnitine + Hydrocodone, Pseudoephedrine, Chlorpheniramine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hydrocodone, Pseudoephedrine, Chlorpheniramine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hydrocodone, Pseudoephedrine, Chlorpheniramine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hydrocodone, Pseudoephedrine, Chlorpheniramine sits in 14 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine, Chlorpheniramine through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine, Chlorpheniramine through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine, Chlorpheniramine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine, Chlorpheniramine through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine, Chlorpheniramine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine, Chlorpheniramine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine, Chlorpheniramine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine, Chlorpheniramine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine, Chlorpheniramine through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine, Chlorpheniramine through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine, Chlorpheniramine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Hydrocodone, Pseudoephedrine, Chlorpheniramine through this category.

Pseudoephedrine (Sudafed) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Hydrocodone, Pseudoephedrine, Chlorpheniramine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Hydrocodone, Pseudoephedrine, Chlorpheniramine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hydrocodone, Pseudoephedrine, Chlorpheniramine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hydrocodone, Pseudoephedrine, Chlorpheniramine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Prefer typing? The interaction checker looks up products by name too.

Products that contain Hydrocodone, Pseudoephedrine, Chlorpheniramine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Hydrocodone, Pseudoephedrine, Chlorpheniramine.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Hydrocodone, Pseudoephedrine, Chlorpheniramine & Supplements: Common Questions

What supplements interact with Hydrocodone, Pseudoephedrine, Chlorpheniramine?
In our interaction database, 285 supplement and herbal ingredients have an interaction with Hydrocodone, Pseudoephedrine, Chlorpheniramine on file — 16 rated major, 228 moderate, and 41 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Beer, Grapefruit, Wine.
Which Hydrocodone, Pseudoephedrine, Chlorpheniramine supplement interactions are the most serious?
The 16 major-rated combinations — led by Beer, Grapefruit, Wine, 1,4-butanediol and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Hydrocodone, Pseudoephedrine, Chlorpheniramine?
That depends entirely on which supplement. The honest answer for Hydrocodone, Pseudoephedrine, Chlorpheniramine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Zutripro have the same supplement interactions as Hydrocodone, Pseudoephedrine, Chlorpheniramine?
Yes — Zutripro all contain Hydrocodone, Pseudoephedrine, Chlorpheniramine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Hydrocodone, Pseudoephedrine, Chlorpheniramine and my other medications?
This page covers Hydrocodone, Pseudoephedrine, Chlorpheniramine against supplements and herbal ingredients. Checking Hydrocodone, Pseudoephedrine, Chlorpheniramine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.