Drug & supplement interaction

Lycopene + Dipyridamole

Dipyridamole brand names: Persantine, Dipyridamole, Persantin, Persantin Injection, Persantin Retard.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Lycopene has a moderate interaction with Dipyridamole. Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Lycopene and Dipyridamole

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Dipyridamole

Dipyridamole falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Lycopene interacts with.

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with dipyridamole and lycopene. Dipyridamole is already an antiplatelet medicine, meaning it makes your platelets less likely to clump and form clots, which is exactly why it's used after a heart valve replacement. In lab studies, lycopene has shown some mild antiplatelet activity of its own. The thought is that stacking the two together could nudge your bleeding risk a little higher.

I want to be straight with you though: this is a theoretical concern based on test-tube research, not on real patients having problems. The lycopene you get from tomatoes, watermelon, and other foods is very unlikely to matter. Concentrated high-dose supplements are the bigger question mark. If you notice easy bruising, nosebleeds, or bleeding gums, or you're considering a supplement, check with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Hsiao, G., Wang, Y., Tzu, N. H., Fong, T. H., Shen, M. Y., Lin, K. H., Chou, D. S., and Sheu, J. R. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J Lab Clin Med 2005;146(4):216-226. PubMed
  2. O'Kennedy, N., Crosbie, L., Whelan, S., Luther, V., Horgan, G., Broom, J. I., Webb, D. J., and Duttaroy, A. K. Effects of tomato extract on platelet function: a double-blinded crossover study in healthy humans. Am.J.Clin.Nutr. 2006;84(3):561-569. PubMed
  3. Sawardekar SB, Patel TC, Uchil D. Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: an in vitro study. Indian J Pharmacol 2016;48:26-31. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Lycopene Also Interacts With Other Medications

Lycopene has 121 moderate known drug interactions in our database — the Dipyridamole one above is one of them. If you take anything else, check it against the full list below.

Moderate 121 No known interaction 2,709 (incl. Dipyridamole)
Taking anything else?

Check Another of Your Medications Against Lycopene

Covers the 2,830 medications we’ve checked against Lycopene. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Dipyridamole

This page covers Lycopene only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dipyridamole page lists 219 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adenosine (major), Danshen (major), Piracetam (major) and Aconite (moderate).

By severity: 4 major · 190 moderate · 25 minor.

From our pharmacist’s overview on the Dipyridamole page

“Dipyridamole (Persantine) keeps platelets from clumping so clots don't form, often after a stroke or heart valve surgery, and that job is exactly why the 219 supplements on this page warrant real vigilance. The bulk of the list, including most of the 190 moderate entries, adds its own blood-thinning or antiplatelet effect on top of the…”

Reviewed by 2 · Jul 18, 2026

Open the Dipyridamole interaction page

One more smart check

Taking Lycopene as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,889 real supplement products containing Lycopene, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lycopene. Your product may carry other ingredients that interact with Dipyridamole too, on top of Lycopene — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lycopene and Dipyridamole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lycopene
Top 5%

#51 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dipyridamole
Top 25%

#590 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Lycopene

What is Lycopene?

Lycopene
  • Heart health
  • Prostate health
  • Antioxidant support
  • Sun/skin protection
  • General wellness

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence from supplements is mixed and far from conclusive. For most people, getting lycopene from food is a safe and reasonable choice; talk to your pharmacist before taking high-dose supplements.

Read the full Lycopene monograph & all interactions
Medication

About Dipyridamole

What Is Dipyridamole Used For?

Brand names: Persantine, Dipyridamole, Persantin, Persantin Injection, Persantin Retard

Dipyridamole tablets are used alongside warfarin (a blood thinner) to help prevent dangerous blood clots from forming after cardiac valve replacement surgery. It is not used alone for this purpose — it works as an add-on to anticoagulant therapy.

Dipyridamole Injection is used as an alternative to exercise during thallium myocardial perfusion imaging — a type of heart scan that checks blood flow through the coronary arteries. It is given to patients who are unable to exercise adequately for the test.

See full Dipyridamole drug information
Keep checking

Other Drugs & Lycopene

Browse every other medication we’ve checked against Lycopene — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
121Moderate
0Minor
2,708No known interaction
121 Moderate 2,708 No interaction
Moderate

121 interactions

Showing 60 of 121 moderate interactions — see all 121 on the Lycopene page.

No interaction 2,708 drugs checked — show the list

We also checked Lycopene against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,708 medications checked with no known interaction — see the full Lycopene list.

See the full Lycopene interactions page
See every supplement checked against Dipyridamole, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
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Pharmacist Counseling Corner

Taking Lycopene and Dipyridamole Together: Common Questions

Can you take Lycopene with Dipyridamole?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Lycopene and Dipyridamole interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Dipyridamole and Lycopene?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.