Drug & supplement interaction

Magnolia + Botulinum Toxin Type A

Botulinum Toxin Type A brand name: Botox.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Magnolia and Botulinum Toxin Type A in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Magnolia and Botulinum Toxin Type A

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Botulinum Toxin Type A and Magnolia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Magnolia safety at a glance

Magnolia overall Use caution May be okay short-term for many adults, but human safety data is limited.
Pregnancy Unsafe When the magnolia flower bud is used orally due to reports of uterine stimulant activity. There is insufficient reliable information available about the safety... Read the full pregnancy detail
Breastfeeding Avoid No reliable safety data during breastfeeding, so it is best avoided.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Botulinum Toxin Type A and Magnolia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Magnolia Does Interact With Other Medications

Magnolia has 351 moderate known drug interactions in our database — Botulinum Toxin Type A isn’t one of them. If you take anything else, check it against the full list below.

Moderate 351 No known interaction 2,479 (incl. Botulinum Toxin Type A)
Taking anything else?

Check Another of Your Medications Against Magnolia

Covers the 2,830 medications we’ve checked against Magnolia. Pick one to open its full report.

What to actually watch for

What Magnolia Itself Has Been Linked To

This is not an interaction — nothing below involves Botulinum Toxin Type A. It is the side-effect record for Magnolia on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Magnolia, this list is the first place to look.

  • Heartburn Additional detail

    “In a clinical trial of an oral combination product containing extracts of magnolia and phellodendron, one patient reported heartburn. However, it's not known if this side effect is related to magnolia or some other factor.”

    Magnolia · Natural Medicines adverse-effect record, reported in dyspepsia.

    1 source cited
    1. 14349. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
  • Erection problems Additional detail

    “In a clinical trial of an oral combination product containing extracts of magnolia and phellodendron, one patient reported sexual dysfunction. However, it's not known if this side effect is related to magnolia or some other factor.”

    Magnolia · Natural Medicines adverse-effect record, reported in antidepressant-induced sexual dysfunction.

    1 source cited
    1. 14349. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
  • Tremor or shakiness / Numbness or tingling / Tiredness / Headache Additional detail

    “In a clinical trial of an oral combination product containing extracts of magnolia and phellodendron, one patient reported shaking hands and perilabial numbness. Another patient reported fatigue and headache. However, it's not known if these side effects are related to magnolia or some other factor.”

    Magnolia · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 14349. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
  • A skin rash Additional detail

    “Topically, magnolia bark has been associated with reports of allergic contact dermatitis. In several cases, the use of anti-aging facial creams containing magnolia bark extract was associated with allergic contact dermatitis of the face. In one case, the use of a vaginal gel containing magnolia bark extract was associated with allergic contact dermatitis of the vulva.”

    Magnolia · Natural Medicines adverse-effect record, reported in dermatitis.

    4 sources cited
    1. 92463. Ghys K, De Palma A, Vandevenne A, Werbrouck J, Goossens A. Magnolia officinalis bark extract, a recently identified contact allergen in 'anti-ageing' cosmetics. Contact Dermatitis. 2015 Aug;73(2):130-2.
    2. 92468. Raison-Peyron N, Césaire A, Du-Thanh A, Dereure O. Allergic contact dermatitis caused by Magnolia officinalis bark extract in a facial anti-ageing cream. Contact Dermatitis. 2015 Jun;72(6):416-7.
    3. 95030. Nilausen TD, Johansen JD, Thyssen JP. Allergic contact dermatitis of the face caused by Magnolia officinalis bark extract. Contact Dermatitis. 2016;75(6):385-87.
    4. 110709. Amat-Samaranch V, López-Sánchez C, Tubau C, Puig L, Serra-Baldrich E. Vulvar allergic contact dermatitis caused by Magnolia officinalis bark extract. Contact Dermatitis 2022;87(1):96-97.

Everything above comes from the Natural Medicines adverse-effect record for Magnolia — expand a row for the licensed statement it rests on. We haven’t matched Botulinum Toxin Type A to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Botulinum Toxin Type A.

Special populations

Magnolia in Pregnancy & Breastfeeding

Pregnancy Unsafe

When the magnolia flower bud is used orally due to reports of uterine stimulant activity. There is insufficient reliable information available about the safety of using magnolia bark during pregnancy; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Botulinum Toxin Type A Is Prescribed For, and What Magnolia Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Botulinum Toxin Type A is a prescription medicine with approved uses on its FDA label. Magnolia is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Botulinum Toxin Type A is prescribed for: Botox is approved to treat a wide range of conditions in adults and some children. These include overactive bladder (OAB) with urge incontinence, urinary incontinence caused by nerve-related bladder overactivity (in adults and in children aged 5 and older), prevention of headaches in adults with chronic migraine (15 or more headache days per month), muscle stiffness (spasticity) in patients aged 2 and older, cervical dystonia (abnormal head position and neck pain), severe underarm sweating (primary axillary hyperhidrosis) when topical treatments haven't worked, eyelid spasms (blepharospasm) in patients aged 12 and older, and crossed eyes (strabismus) in patients aged 12 and older. BOTOX Cosmetic is a separate product containing the same active ingredient but with its own approved cosmetic uses. Both products are given by injection and are not interchangeable with other botulinum toxin products.

Read the rest of what Botulinum Toxin Type A is prescribed for

Botox has not been shown to work for episodic migraine (14 or fewer headache days per month), and its safety for excessive sweating in body areas other than the underarms has not been established.

Magnolia has been studied for:

  • Headache studied, not established Magnolia has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Magnolia for headache

    Although there is interest in using oral magnolia for headache, there is insufficient reliable information about the clinical effects of magnolia for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Botulinum Toxin Type A on your own; if you are taking Magnolia for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Magnolia or Botulinum Toxin Type A

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Magnolia or Botulinum Toxin Type A, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

One more smart check

Taking Magnolia as Part of a Dietary Supplement Product? Check It for Interactions

We hold 736 real supplement products containing Magnolia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Magnolia. Even though Magnolia itself has no known interaction with Botulinum Toxin Type A, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Magnolia and Botulinum Toxin Type A Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Magnolia
Top 25%

#237 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Botulinum Toxin Type A
Top half

#1,022 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Magnolia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Magnolia and Botulinum Toxin Type A records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Magnolia

What is Magnolia?

Magnolia
  • Anxiety and stress
  • Sleep problems
  • Digestive upset
  • Inflammation
  • Nasal congestion and allergies (flower bud)

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human research is still limited, so we can't be sure how well it works for most uses. Talk with your pharmacist or doctor before trying it, especially if you take other medicines or are pregnant.

Magnolia officinalis · Magnoliaceae · Bark and flower buds · Capsules, tablets, tea, tinctures, and some toothpastes or skin products

An interaction check asks whether these two react with each other — it does not ask whether Magnolia is a good idea for someone in your situation. Here is what our Magnolia record says about it on its own.

Magnolia: dosing

There is no well-established standard dose of Magnolia. Products vary widely in how they are prepared and how concentrated they are, and many supplements combine Magnolia with other ingredients.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Magnolia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Magnolia monograph & all interactions
Medication

About OnabotulinumtoxinA Injection

What Is OnabotulinumtoxinA Injection Used For?

Brand name: Botox

Botox is approved to treat a wide range of conditions in adults and some children. These include overactive bladder (OAB) with urge incontinence, urinary incontinence caused by nerve-related bladder overactivity (in adults and in children aged 5 and older), prevention of headaches in adults with chronic migraine (15 or more headache days per month), muscle stiffness (spasticity) in patients aged 2 and older, cervical dystonia (abnormal head position and neck pain), severe underarm sweating (primary axillary hyperhidrosis) when topical treatments haven't worked, eyelid spasms (blepharospasm) in patients aged 12 and older, and crossed eyes (strabismus) in patients aged 12 and older.

BOTOX Cosmetic is a separate product containing the same active ingredient but with its own approved cosmetic uses. Both products are given by injection and are not interchangeable with other botulinum toxin products. Botox has not been shown to work for episodic migraine (14 or fewer headache days per month), and its safety for excessive sweating in body areas other than the underarms has not been established.

Most-Reported Side Effects for Botulinum Toxin Type A

From FAERS, the FDA’s public side-effect reporting system (12,344 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 1,596 reports
Drug intolerance 1,333 reports
Nausea 1,266 reports
Migraine 1,176 reports
Dizziness 1,126 reports
See full OnabotulinumtoxinA Injection drug information
Keep checking

Other Drugs & Magnolia

Browse every other medication we’ve checked against Magnolia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
351Moderate
0Minor
2,478No known interaction
351 Moderate 2,478 No interaction
Moderate

351 interactions

Showing 60 of 351 moderate interactions — see all 351 on the Magnolia page.

No interaction 2,478 drugs checked — show the list

We also checked Magnolia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,478 medications checked with no known interaction — see the full Magnolia list.

See the full Magnolia interactions page
See every supplement checked against Botulinum Toxin Type A, ranked by severity
Evidence & sources

Magnolia References

The 9 references that drive our Magnolia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kuribara H, Kishi E, Hattori N, et al. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol 2000;52:1425-9. PubMed
  2. Tachikawa E, Takahashi M, Kashimoto T. Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells. Biochem Pharmacol 2000;60:433-40. PubMed
  3. Jung KY, Kim DS, Oh SR, et al. Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. J Nat Prod 1998;61:808-11.
  4. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
  5. Teng CM, Chen CC, Ko FN, et al. Two antiplatelet agents from Magnolia officinalis. Thromb Res 1988;50:757-65. PubMed
  6. Ghys K, De Palma A, Vandevenne A, Werbrouck J, Goossens A. Magnolia officinalis bark extract, a recently identified contact allergen in 'anti-ageing' cosmetics. Contact Dermatitis. 2015 Aug;73(2):130-2.
  7. Raison-Peyron N, Césaire A, Du-Thanh A, Dereure O. Allergic contact dermatitis caused by Magnolia officinalis bark extract in a facial anti-ageing cream. Contact Dermatitis. 2015 Jun;72(6):416-7.
  8. Nilausen TD, Johansen JD, Thyssen JP. Allergic contact dermatitis of the face caused by Magnolia officinalis bark extract. Contact Dermatitis. 2016;75(6):385-87.
  9. Amat-Samaranch V, López-Sánchez C, Tubau C, Puig L, Serra-Baldrich E. Vulvar allergic contact dermatitis caused by Magnolia officinalis bark extract. Contact Dermatitis 2022;87(1):96-97.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Magnolia and Botulinum Toxin Type A Together: Common Questions

Is it safe to take Magnolia with Botulinum Toxin Type A?
We do not list a known interaction between Magnolia and Botulinum Toxin Type A. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Magnolia and Botulinum Toxin Type A used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Magnolia in each. That is a conversation for your prescriber, especially if Botulinum Toxin Type A is being adjusted to a target.
Does Magnolia interact with any other medications?
Yes. Magnolia has 351 documented drug interactions in our database — Botulinum Toxin Type A is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Magnolia monograph Uses, safety profile, and every drug interaction in one place OnabotulinumtoxinA Injection drug information The full plain-English guide to this medication Botulinum Toxin Type A supplement interactions Every supplement checked against Botulinum Toxin Type A, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Botulinum Toxin Type A and Magnolia?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.