Drug & supplement interaction

Maritime Pine + Formoterol

Formoterol brand names: Foradil Aerolizer, Atimos Modulite, Oxis Turbohaler, Perforomist, Foradil Certihaler.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Maritime Pine and Formoterol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Maritime Pine and Formoterol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Formoterol and Maritime Pine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Maritime Pine safety at a glance

Maritime Pine overall Use caution Generally well tolerated in studies, but long-term safety is not fully established.
Pregnancy Possibly Safe When used orally during the third trimester of pregnancy. In one small clinical study, a standardized extract of maritime pine bark (Pycnogenol, Horphag Researc... Read the full pregnancy detail
Breastfeeding Avoid Not enough safety data, so it is best avoided while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Formoterol and Maritime Pine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Formoterol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Formoterol is filed under 3 classifications — cytochrome p450 2c19 (cyp2c19) substrates, cytochrome p450 2c9 (cyp2c9) substrates, cytochrome p450 2d6 (cyp2d6) substrates. Maritime Pine has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and immunosuppressants (moderate) — and none of Formoterol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Maritime Pine Does Interact With Other Medications

Maritime Pine has 327 moderate known drug interactions in our database — Formoterol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 327 No known interaction 2,503 (incl. Formoterol)
Taking anything else?

Check Another of Your Medications Against Maritime Pine

Covers the 2,830 medications we’ve checked against Maritime Pine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Maritime Pine and Formoterol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Chest pain Worth acting on Additional detail

    Maritime Pine

    “A single case of chest pain has been reported for a patient treated with a standardized extract of maritime pine bark (Pycnogenol, Horphag Research). However, the patient had a history of myocardial infarction. Another patient taking the same maritime pine bark extract experienced acute decompensation of heart failure. The patient previously has stable coronary artery disease.”

    Maritime Pine · Natural Medicines adverse-effect record, reported in congestive heart failure (chf).

    2 sources cited
    1. 50905. Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
    2. 50929. Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects

    Formoterol

    Listed in the ADVERSE REACTIONS section of the FDA label for Formoterol. Read the label on DailyMed ›

  • Dizziness Additional detail

    Maritime Pine

    “Orally, a standardized extract of maritime pine bark (Pycnogenol, Horphag Research) may cause dizziness and severe vertigo. Also, headache has been reported in a single trial.”

    Maritime Pine · Natural Medicines adverse-effect record, reported in cluster headache.

    5 sources cited
    1. 15521. Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
    2. 15522. Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
    3. 17300. Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
    4. 50904. Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
    5. 50933. Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.

    Formoterol

    Listed in the ADVERSE REACTIONS section of the FDA label for Formoterol. Read the label on DailyMed ›

  • Headache Additional detail

    Maritime Pine

    Recorded for Maritime Pine in the same Natural Medicines adverse-effect record shown under Dizziness above.

    Formoterol

    Listed in the ADVERSE REACTIONS section of the FDA label for Formoterol. Read the label on DailyMed ›

Reported for Maritime Pine but not commonly for Formoterol: a heart attack and heart failure.

Effects for Formoterol come from the ADVERSE REACTIONS section of its FDA label; effects for Maritime Pine come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Maritime Pine in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used orally during the third trimester of pregnancy. In one small clinical study, a standardized extract of maritime pine bark (Pycnogenol, Horphag Research) has been used at a dose of 30 mg daily with apparent safety during the third trimester of pregnancy. However, more evidence is needed; use cautiously or avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Formoterol Is Prescribed For, and What Maritime Pine Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Formoterol is a prescription medicine with approved uses on its FDA label. Maritime Pine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Formoterol is prescribed for: Formoterol fumarate inhalation solution is used for the long-term maintenance treatment of airway narrowing (bronchoconstriction) in adults with COPD, including chronic bronchitis and emphysema. It is taken twice daily — morning and evening — as a regular, ongoing treatment. Important limits: This medication is not for relieving sudden COPD flare-ups or breathlessness in the moment, and it is not approved to treat asthma. A separate short-acting inhaler should always be on hand for sudden symptoms.

Maritime Pine has been studied for:

  • Asthma Natural Medicines rates the evidence for Maritime Pine: Possibly Effective Read what the research shows

    Maritime Pine for asthma

    Oral maritime pine bark extract, taken as an adjunct to conventional asthma medications, may improve symptoms and reduce rescue inhaler use in patients with asthma.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Formoterol on your own; if you are taking Maritime Pine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Formoterol

This page covers Maritime Pine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Formoterol page lists 103 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,3-dmaa (moderate), Acacia Rigidula (moderate), Active Hexose Correlated Compound (ahcc) (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 84 moderate · 19 minor.

From our pharmacist’s overview on the Formoterol page

“Formoterol (Foradil, Perforomist) is the long-acting half of many asthma and COPD inhalers, keeping airways open for hours, and its supplement list is calmer than its length suggests. None of the 103 ingredients on file is rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Formoterol interaction page

One more smart check

Taking Maritime Pine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 452 real supplement products containing Maritime Pine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Maritime Pine. Even though Maritime Pine itself has no known interaction with Formoterol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Maritime Pine and Formoterol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Maritime Pine
Top 25%

#319 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Formoterol
Steady interest

#2,418 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Maritime Pine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Maritime Pine and Formoterol records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Maritime Pine

What is Maritime Pine?

Maritime Pine
  • Circulation and vein health
  • Antioxidant support
  • Skin health and aging
  • High blood pressure
  • Joint comfort

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research is promising, but many studies are small or industry-funded, so benefits are not firmly proven. It is generally well tolerated, but talk to your pharmacist or doctor before starting it.

Pinus pinaster · Pinaceae · Bark (extract) · Capsules, tablets, creams, and topical gels

An interaction check asks whether these two react with each other — it does not ask whether Maritime Pine is a good idea for someone in your situation. Here is what our Maritime Pine record says about it on its own.

Maritime Pine: dosing

There is no single official dose of maritime pine bark extract. Doses used in studies have varied depending on the product and the condition being studied, and most research has used standardized branded extracts.Because strength and quality differ between brands, follow the directions on the product label and do not exceed the recommended amount.

From our Maritime Pine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Maritime Pine monograph & all interactions
Medication

About Formoterol Oral Inhalation

What Is Formoterol Oral Inhalation Used For?

Brand names: Foradil Aerolizer, Atimos Modulite, Oxis Turbohaler, Perforomist, Foradil Certihaler

Formoterol fumarate inhalation solution is used for the long-term maintenance treatment of airway narrowing (bronchoconstriction) in adults with COPD, including chronic bronchitis and emphysema. It is taken twice daily — morning and evening — as a regular, ongoing treatment.

Important limits: This medication is not for relieving sudden COPD flare-ups or breathlessness in the moment, and it is not approved to treat asthma. A separate short-acting inhaler should always be on hand for sudden symptoms.

See full Formoterol Oral Inhalation drug information
Keep checking

Other Drugs & Maritime Pine

Browse every other medication we’ve checked against Maritime Pine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
327Moderate
0Minor
2,502No known interaction
327 Moderate 2,502 No interaction
Moderate

327 interactions

Showing 60 of 327 moderate interactions — see all 327 on the Maritime Pine page.

No interaction 2,502 drugs checked — show the list

We also checked Maritime Pine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,502 medications checked with no known interaction — see the full Maritime Pine list.

See the full Maritime Pine interactions page
See every supplement checked against Formoterol, ranked by severity
Evidence & sources

Maritime Pine References

The 14 references that drive our Maritime Pine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
  2. Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. PubMed
  3. Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. PubMed
  4. Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4.
  5. Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
  6. Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
  7. Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
  8. Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. PubMed
  9. Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychi PubMed
  10. Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
  11. Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
  12. Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects
  13. Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.
  14. Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Maritime Pine and Formoterol Together: Common Questions

Is it safe to take Maritime Pine with Formoterol?
We do not list a known interaction between Maritime Pine and Formoterol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Maritime Pine and Formoterol have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Maritime Pine and Formoterol used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Maritime Pine in each. That is a conversation for your prescriber, especially if Formoterol is being adjusted to a target.
How was the Maritime Pine and Formoterol combination checked?
Interactions in our licensed database are recorded against drug classes. Formoterol is filed under 3 classifications, and Maritime Pine has documented interactions with 3 drug classes — none of Formoterol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Maritime Pine interact with any other medications?
Yes. Maritime Pine has 327 documented drug interactions in our database — Formoterol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Formoterol interact with any supplements?
Yes. Formoterol has documented interactions with 103 supplements in our database — Maritime Pine is not one of them. The Formoterol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Maritime Pine monograph Uses, safety profile, and every drug interaction in one place Formoterol Oral Inhalation drug information The full plain-English guide to this medication Formoterol supplement interactions Every supplement checked against Formoterol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Formoterol and Maritime Pine?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.