Marjoram - Zontivity (Vorapaxar) Interaction
Herbal: Marjoram
Also Known As: Origanum majorana, Essence de Marjolaine, Garden Marjoram, Gartenmajoran, Huile de Marjolaine, Knotted Marjoram, Maggiorana, Majoran, Majorana Aetheroleum Oil, Majorana Herb, Manjerona, Mardkouch, Marjolaine, Marjolaine des Jardins, Marjolaine Ordinaire
Drug: Vorapaxar
Brand names:
Zontivity
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 18, 2025
Interaction Details
Vorapaxar is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
In vitro research suggests that marjoram extract inhibits platelet aggregation and adhesion. Theoretically, marjoram might increase the risk of bleeding when used in medicinal amounts along with antiplatelet or anticoagulant drugs.
Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Yazdanparast, R. and Shahriyary, L. Comparative effects of Artemisia dracunculus, Satureja hortensis and Origanum majorana on inhibition of blood platelet adhesion, aggregation and secretion. Vascul.Pharmacol 2008;48(1):32-37.
Marjoram Overview
Marjoram is an herb native to the Mediterranean region and is related to oregano. It is often utilized in several ways, including as food and in commercial products, such as soaps.
Marjoram is a good source of antioxidants and is purported to have a variety of potential health benefits. It has been used in traditional medicine to several conditions, including respiratory problems, insomnia, and digestive disorders. It is also sometimes used in aromatherapy to promote relaxation and stress relief.
Vorapaxar Overview
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Vorapaxar is used together with other medications, such as aspirin and clopidogrel (Plavix), to reduce the risk of serious or life-threatening heart or blood vessel problems such as heart attack and stroke in people who have already had a heart attack or have problems with the blood flow in their legs. Vorapaxar is in a class of medications called protease-activated receptor-1 (PAR-1) antagonists. It works by preventing platelets (a type of blood cell) from collecting and forming clots that may cause a heart attack or stroke.
Marjoram - More Interactions
Marjoram interacts with 334 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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