Drug & supplement interaction

Marshmallow + Imiquimod

Imiquimod brand names: Aldara, Zyclara, Vyloma.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Marshmallow and Imiquimod in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Marshmallow and Imiquimod

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Imiquimod and Marshmallow in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Marshmallow safety at a glance

Marshmallow overall Use caution Generally well tolerated for short-term use, but human safety data are limited.
Pregnancy Avoid Not enough reliable safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Not enough reliable safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Imiquimod and Marshmallow? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Imiquimod

Interactions in our licensed database are recorded against drug classes, not just single drug names. Imiquimod is filed under a single classification — topical drugs. Marshmallow has documented interactions with 3 drug classes — the most serious being lithium (moderate), anticoagulant/antiplatelet drugs (minor) and oral drugs (minor) — and none of Imiquimod’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Marshmallow Does Interact With Other Medications

Marshmallow has 1 moderate, 2,039 minor known drug interactions in our database — Imiquimod isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 Minor 2,039 No known interaction 790 (incl. Imiquimod)
Taking anything else?

Check Another of Your Medications Against Marshmallow

Covers the 2,830 medications we’ve checked against Marshmallow. Pick one to open its full report.

What to actually watch for

What Imiquimod’s Own FDA Label Lists

This is not an interaction — none of it involves Marshmallow. These are the most notable effects listed in the ADVERSE REACTIONS section of Imiquimod’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on
  • Back pain
  • Fever
  • Itching
  • Swelling
  • Tiredness
  • Dizziness
  • Diarrhea
  • Headache

From the ADVERSE REACTIONS section of the FDA label for Imiquimod. Read the label on DailyMed › Marshmallow’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Marshmallow side to compare — that is a limit of the record, not a statement that Marshmallow has no side effects.

Everything else you take

See Every Supplement That Interacts With Imiquimod

This page covers Marshmallow only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Imiquimod page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Imiquimod page

“Imiquimod (Aldara, Zyclara, Vyloma) is a cream for warts, precancerous spots, and certain skin cancers, and its supplement list is short and workable for most people. Only 3 ingredients are on file, none rated major, and all involve products applied to the skin rather than swallowed.”

Reviewed by 2 · Jul 18, 2026

Open the Imiquimod interaction page

One more smart check

Taking Marshmallow as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,622 real supplement products containing Marshmallow, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Marshmallow. Even though Marshmallow itself has no known interaction with Imiquimod, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Marshmallow and Imiquimod Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Marshmallow
Top 10%

#121 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Imiquimod
Steady interest

#1,982 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Marshmallow reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Marshmallow and Imiquimod records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Marshmallow

What is Marshmallow?

Marshmallow
  • Cough and sore throat
  • Dry mouth and throat irritation
  • Digestive upset and heartburn
  • Skin irritation
  • Soothing inflamed tissue

Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats, and stomach irritation. Evidence for these uses is mostly traditional and preliminary, but it is generally considered gentle and well-tolerated for short-term use. As with any supplement, check with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.

Althaea officinalis · Malvaceae · Root and leaves · Tea, capsules, tinctures, syrups, lozenges, dried root, topical creams

An interaction check asks whether these two react with each other — it does not ask whether Marshmallow is a good idea for someone in your situation. Here is what our Marshmallow record says about it on its own.

Marshmallow: dosing

There is no official, standardized dose for marshmallow. The right amount depends on the form (tea, capsule, syrup, lozenge, or tincture) and the specific product.The safest approach is to follow the directions on the product label and not exceed the recommended amount. For teas, the dried root is often steeped in water; for other forms, the manufacturer's instructions should guide you.When taking marshmallow as a capsule or tincture, it is often recommended to drink plenty of water.

From our Marshmallow monograph — the full record covers uses, side effects and every documented interaction.

Read the full Marshmallow monograph & all interactions
Medication

About Imiquimod Topical

What Is Imiquimod Topical Used For?

Brand names: Aldara, Zyclara, Vyloma

Imiquimod cream is used to treat three skin conditions in adults: actinic keratoses (rough, scaly patches on the skin caused by sun damage) on the face or scalp; superficial basal cell carcinoma (a type of skin cancer) on the trunk, neck, or limbs when surgery is not the best option; and external genital and perianal warts (condyloma acuminata) in patients 12 years and older.

It is not effective for molluscum contagiosum in children ages 2–12, and it has not been proven safe or effective in people with weakened immune systems. It should not be used for warts inside the urethra, vagina, cervix, rectum, or anal canal.

Most-Reported Side Effects for Imiquimod

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Erythema 183 reports
Fatigue 179 reports
Nausea 114 reports
Influenza like illness 102 reports
Application site erythema 100 reports
See full Imiquimod Topical drug information
Keep checking

Other Drugs & Marshmallow

Browse every other medication we’ve checked against Marshmallow — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
2,039Minor
789No known interaction
1 Moderate 2,039 Minor 789 No interaction
Moderate

1 interaction

Minor

2,039 interactions

Showing 60 of 2,039 minor interactions — see all 2,039 on the Marshmallow page.

No interaction 789 drugs checked — show the list

We also checked Marshmallow against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 789 medications checked with no known interaction — see the full Marshmallow list.

See the full Marshmallow interactions page
See every supplement checked against Imiquimod, ranked by severity
Evidence & sources

Marshmallow References

The 5 references that drive our Marshmallow monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Hage-Sleiman R, Mroueh M, Daher CF. Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon. Pharm Biol 2011;49(3):327-33.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Marshmallow and Imiquimod Together: Common Questions

Is it safe to take Marshmallow with Imiquimod?
We do not list a known interaction between Marshmallow and Imiquimod. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Marshmallow and Imiquimod combination checked?
Interactions in our licensed database are recorded against drug classes. Imiquimod is filed under 1 classification, and Marshmallow has documented interactions with 3 drug classes — none of Imiquimod's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Marshmallow interact with any other medications?
Yes. Marshmallow has 2,040 documented drug interactions in our database — Imiquimod is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Imiquimod interact with any supplements?
Yes. Imiquimod has documented interactions with 3 supplements in our database — Marshmallow is not one of them. The Imiquimod interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Marshmallow monograph Uses, safety profile, and every drug interaction in one place Imiquimod Topical drug information The full plain-English guide to this medication Imiquimod supplement interactions Every supplement checked against Imiquimod, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Imiquimod and Marshmallow?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.